Publications by authors named "Marc A Holbert"

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High-Throughput Cellular Thermal Shift Assays in Research and Drug Discovery.
Mark J Henderson, Marc A Holbert, Anton Simeonov, Lorena A Kallal

SLAS Discov· February 2020

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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Rosalie Matico, Lawrence M Szewczuk, Beth Pietrak, Stephanie Chen, Ed Dul, Marc A Holbert

Sci Rep· September 2019

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Development of a high-content imaging assay for screening compound aggregation.
Yong Jiang, Ann Hoffman, Geoffrey Quinque, William G Bonnette, Lawrence M Szewczuk, Marc A Holbert

Anal Biochem· October 2018

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A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
Dean E McNulty, William G Bonnette, Hongwei Qi, Liping Wang, Thau F Ho, Marc A Holbert

SLAS Discov· January 2018

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Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.
Yong Jiang, Juan Wang, Guofeng Zhang, Khyati Oza, Linda Myers, Marc A Holbert

Protein Expr Purif· May 2014

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An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.
Meng-Jung Chiang, Marc A Holbert, Jay H Kalin, Young-Hoon Ahn, John Giddens

J Am Chem Soc· March 2014

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Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.
Yong Tang, Marc A Holbert, Neda Delgoshaie, Hugo Wurtele, Benoît Guillemette

Structure· February 2011

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Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.
Rong Huang, Marc A Holbert, Mary Katherine Tarrant, Sandrine Curtet, David R Colquhoun

J Am Chem Soc· July 2010

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Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Erin M Bowers, Gai Yan, Chandrani Mukherjee, Andrew Orry, Ling Wang, Marc A Holbert

Chem Biol· May 2010

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Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
Yong Tang, Marc A Holbert, Hugo Wurtele, Katrina Meeth, Walter Rocha

Nat Struct Mol Biol· July 2008

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The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting.
Marc A Holbert, Timothy Sikorski, Juliana Carten, Danielle Snowflack, Santosh Hodawadekar

J Biol Chem· December 2007

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De novo discovery of serotonin N-acetyltransferase inhibitors.
Lawrence M Szewczuk, S Adrian Saldanha, Surajit Ganguly, Erin M Bowers, Margarita Javoroncov, Marc A Holbert

J Med Chem· November 2007

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Protein tyrosine kinase-substrate interactions.
Ron Bose, Marc A Holbert, Kerry A Pickin, Philip A Cole

Curr Opin Struct Biol· December 2006

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
Stephen M Sykes, Hestia S Mellert, Marc A Holbert, Keqin Li, Ronen Marmorstein

Mol Cell· December 2006

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Structure and activity of enzymes that remove histone modifications.
Marc A Holbert, Ronen Marmorstein

Curr Opin Struct Biol· December 2005

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