Publications by authors named "Jean Cavarelli"

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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Giulia Iannelli, Ciro Milite, Nils Marechal, Vincent Cura, Luc Bonnefond, Jean Cavarelli

J Med Chem· September 2022

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A Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1.
Yurui Zhang, Matthijs J van Haren, Nils Marechal, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli

Biochemistry· May 2022

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Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.
Yurui Zhang, Nils Marechal, Matthijs J van Haren, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli

Chembiochem· December 2021

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Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase.
Vincent Cura, Jean Cavarelli

Life (Basel)· November 2021

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FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.
Thomas Di Mattia, Arthur Martinet, Souade Ikhlef, Alastair G McEwen, Yves Nominé, Jean Cavarelli

EMBO J· December 2020

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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.
Emmanuel Salomon, Marjorie Schmitt, Elisabeth Mouray, Alastair G McEwen, Lotfi Bounaadja, Jean Cavarelli

Bioorg Chem· May 2020

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Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Ludovic Halby, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, Jean Cavarelli

Philos Trans R Soc Lond B Biol Sci· June 2018

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Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.
Guanya Peng, Alastair G McEwen, Vincent Olieric, Celine Schmitt, Sebastien Albrecht, Jean Cavarelli

Proteins· August 2017

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SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.
Anne-Sophie Gribling-Burrer, Michael Leichter, Laurence Wurth, Alexandra Huttin, Florence Schlotter, Jean Cavarelli

Nucleic Acids Res· May 2017

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Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Matthijs J van Haren, Nils Marechal, Nathalie Troffer-Charlier, Agostino Cianciulli, Gianluca Sbardella, Jean Cavarelli

Proc Natl Acad Sci U S A· April 2017

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Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
Vincent Cura, Nils Marechal, Nathalie Troffer-Charlier, Jean-Marc Strub, Matthijs J van Haren, Jean Cavarelli

FEBS J· January 2017

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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.
Stéphanie Thébault, Morgane Agez, Xiaoke Chi, Johann Stojko, Vincent Cura, Jean Cavarelli

Sci Rep· January 2016

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Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Luc Bonnefond, Johann Stojko, Justine Mailliot, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli

J Struct Biol· August 2015

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Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.
Olga Kolaj-Robin, Alastair G McEwen, Jean Cavarelli, Bertrand Séraphin

FEBS J· March 2015

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Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Diana A Stolfa, Martin Marek, Julien Lancelot, Alexander-Thomas Hauser, Alexandra Walter, Jean Cavarelli

J Mol Biol· October 2014

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Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.
Vincent Cura, Nathalie Troffer-Charlier, Jean Marie Wurtz, Luc Bonnefond, Jean Cavarelli

Acta Crystallogr D Biol Crystallogr· September 2014

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Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Jean Cavarelli

PLoS Pathog· April 2014

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Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.
Vincent Cura, Nathalie Troffer-Charlier, Marie-Annick Lambert, Luc Bonnefond, Jean Cavarelli

Acta Crystallogr F Struct Biol Commun· January 2014

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Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
Katia Zanier, Sebastian Charbonnier, Abdellahi Ould M'hamed Ould Sidi, Alastair G McEwen, Maria Giovanna Ferrario, Jean Cavarelli

Science· February 2013

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On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.
Patrick Schaub, Qiuju Yu, Sandra Gemmecker, Pierre Poussin-Courmontagne, Justine Mailliot, Jean Cavarelli

PLoS One· November 2012

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Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.
Sabrina Castellano, Astrid Spannhoff, Ciro Milite, Fabrizio Dal Piaz, Donghang Cheng, Jean Cavarelli

J Med Chem· November 2012

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Structural insights into transcription complexes.
Imre Berger, Alexandre G Blanco, Rolf Boelens, Jean Cavarelli, Miquel Coll

J Struct Biol· August 2011

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Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Elisabeth-Maria Bissinger, Ralf Heinke, Astrid Spannhoff, Adrien Eberlin, Eric Metzger, Jean Cavarelli

Bioorg Med Chem· June 2011

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Noncanonical tandem SH2 enables interaction of elongation factor Spt6 with RNA polymerase II.
Marie-Laure Diebold, Erin Loeliger, Michael Koch, Fred Winston, Jean Cavarelli

J Biol Chem· December 2010

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The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.
Marie-Laure Diebold, Michael Koch, Erin Loeliger, Vincent Cura, Fred Winston, Jean Cavarelli

EMBO J· December 2010

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