Publications by authors named "Jean Marc Taymans"

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Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.
Akhila Mettu, Marta Glavatskikh, Xiaowen Wang, Antonio Jesús Lara Ordóñez, Fengling Li, Jean-Marc Taymans

Chem Sci· February 2025

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PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner.
Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto, Jean-Marc Taymans

Cell Death Dis· October 2024

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Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date.
Margaux Morez, Antonio Jesús Lara Ordóñez, Patricia Melnyk, Maxime Liberelle, Nicolas Lebègue, Jean-Marc Taymans

Expert Opin Ther Pat· September 2024

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Editorial: Editors' showcase: molecular signalling and pathways.
Jean-Marc Taymans, Deniz Yilmazer-Hanke

Front Mol Neurosci· August 2024

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Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies.
Ciria C Hernandez, Luis E Gimenez, Tim Strassmaier, Marc Rogers, Jean-Marc Taymans

Front Mol Neurosci· May 2024

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A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells.
Yahaira Naaldijk, Belén Fernández, Rachel Fasiczka, Elena Fdez, Coline Leghay, Jean-Marc Taymans

NPJ Parkinsons Dis· January 2024

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PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Jean-Marc Taymans

Front Mol Neurosci· December 2023

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Perspective on the current state of the LRRK2 field.
Jean-Marc Taymans, Matt Fell, Tim Greenamyre, Warren D Hirst, Adamantios Mamais

NPJ Parkinsons Dis· July 2023

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Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs.
Francesca Filippini, Sébastien Nola, Ahmed Zahraoui, Kevin Roger, Mansoore Esmaili, Jean-Marc Taymans

Cell Rep· March 2023

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Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers.
Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke

NPJ Parkinsons Dis· February 2023

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Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.
Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, Jean-Marc Taymans

Mov Disord· August 2022

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The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Susanna Cogo, Franz Y Ho, Elena Tosoni, James E Tomkins, Isabella Tessari, Jean-Marc Taymans

Brain Res· March 2022

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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Antoine Marchand, Alessia Sarchione, Panagiotis S Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, Jean-Marc Taymans

Cells· March 2022

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Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
Matthieu Drouyer, Marc F Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Jean-Marc Taymans

Neurobiol Dis· September 2021

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Alpha-Synuclein and Lipids: The Elephant in the Room?
Alessia Sarchione, Antoine Marchand, Jean-Marc Taymans, Marie-Christine Chartier-Harlin

Cells· September 2021

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The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Jean-Marc Taymans

Int J Mol Sci· June 2021

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Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience.
Jean-Marc Taymans

Front Mol Neurosci· May 2021

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Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.
Liesel Goveas, Eugénie Mutez, Marie-Christine Chartier-Harlin, Jean-Marc Taymans

Cells· April 2021

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Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.
Evy Lobbestael, Chris Van den Haute, Francesca Macchi, Jean-Marc Taymans, Veerle Baekelandt

Biosci Rep· October 2020

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The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Hardy J Rideout, Marie-Christine Chartier-Harlin, Matthew J Fell, Warren D Hirst, Sarah Huntwork-Rodriguez, Jean-Marc Taymans

Front Neurosci· August 2020

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LRRK2 Phosphorylation, More Than an Epiphenomenon.
Antoine Marchand, Matthieu Drouyer, Alessia Sarchione, Marie-Christine Chartier-Harlin, Jean-Marc Taymans

Front Neurosci· June 2020

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Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Belén Fernández, Antonio Jesús Lara Ordóñez, Elena Fdez, Eugénie Mutez, Thomas Comptdaer, Jean-Marc Taymans

Biochem J· October 2019

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In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins.
Jean-Marc Taymans, Marie-Christine Chartier-Harlin

Proteomics· July 2018

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Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J Lara Ordóñez, Marian Blanca Ramírez, Jean-Marc Taymans

Mol Neurodegener· January 2018

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PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
Laura Civiero, Susanna Cogo, Anneleen Kiekens, Claudia Morganti, Isabella Tessari, Jean-Marc Taymans

Front Mol Neurosci· December 2017

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