Publications by authors named "Jean-Christophe Rochet"

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Alzheimer's disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery.
Yanru Ji, Xiaoling Chen, Zhen Wang, Connor Joseph Meek, Jenna Lillie McLean, Jean-Christophe Rochet

Mol Psychiatry· October 2025

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Acrolein-Induced Alterations in Morphology and Stress Resilience in hiPSC-Derived Cortical Neurons.
Junkai Xie, Shichen Wu, Xihui Zhao, Anke M Tukker, Han Zhao, Jean-Christophe Rochet

Environ Sci Technol· October 2025

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Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation.
Sayan Dutta, Jennifer A Hensel, Alicia N Scott, Rodrigo Mohallem, Leigh-Ana M Rossitto, Jean-Christophe Rochet

bioRxiv· June 2025

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Mechanisms of Alpha-Synuclein-Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging.
Paula-Marie E Ivey, Magaly Guzman Sosa, Abdelrahman Salem, Sehong Min, Wenzhu Qi, Jean-Christophe Rochet

ACS Chem Neurosci· June 2025

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Autism-associated deficiency disrupts cortico-striatal circuitry in human brain assembloids.
Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, Morgan J Robinson, Harish Kothandaraman, Jean-Christophe Rochet

bioRxiv· June 2025

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Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying mutation: Microglial diversity and response in assembloids.
Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Jean-Christophe Rochet

bioRxiv· June 2025

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Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer's disease across model systems.
Pablo Martinez, Henika Patel, Yanwen You, Daniella Lopes, Armando Amaro, Jean-Christophe Rochet

bioRxiv· June 2025

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Rotenone induced acute miRNA alterations in extracellular vesicles produce mitochondrial dysfunction and cell death.
Fatema Currim, Josephine Brown-Leung, Tauqeerunnisa Syeda, Matthew Corson, Sofia Schumann, Jean-Christophe Rochet

NPJ Parkinsons Dis· March 2025

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Zero-length crosslinking: A breakthrough approach for evaluating target engagement in α-synuclein immunotherapy.
Jean-Christophe Rochet, Wenzhu Qi, Deniz Kirik

J Pharmacol Exp Ther· January 2025

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Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.
Hammad F Khan, Sayan Dutta, Alicia N Scott, Shulan Xiao, Saumitra Yadav, Jean-Christophe Rochet

Nat Commun· December 2024

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A FRET-Based FLIM Method to Probe Membrane-Induced Alpha-Synuclein Aggregation in Neurons.
Paula-Marie E Ivey, Abdelrahman Salem, Sehong Min, Wenzhu Qi, Magaly Guzman Sosa, Jean-Christophe Rochet

bioRxiv· December 2024

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Mechanisms of Alpha-Synuclein Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging.
Paula-Marie E Ivey, Magaly Guzman Sosa, Abdelrahman Salem, Sehong Min, Wenzhu Qi, Jean-Christophe Rochet

bioRxiv· December 2024

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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated -L1342P mutation.
Zhefu Que, Maria I Olivero-Acosta, Morgan Robinson, Ian Chen, Jingliang Zhang, Jean-Christophe Rochet

J Neurosci· November 2024

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Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Shichen Wu, Junkai Xie, Han Zhao, Xihui Zhao, Oscar F Sánchez, Jean-Christophe Rochet

Environ Int· August 2024

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Identification of predictive patient characteristics for assessing the probability of COVID-19 in-hospital mortality.
Bartek Rajwa, Md Mobasshir Arshed Naved, Mohammad Adibuzzaman, Ananth Y Grama, Babar A Khan, Jean-Christophe Rochet

PLOS Digit Health· April 2024

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Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions.
Fatema Currim, Shatakshi Shukla, Jyoti Singh, Dhruv Gohel, Minal Mane, Jean-Christophe Rochet

Neurotoxicology· March 2024

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Corrigendum to "Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine" [Sci. Total Environ. 908 2024: Article 168307].
Han Zhao, Junkai Xie, Shichen Wu, Xihui Zhao, Oscar F Sánchez, Jean-Christophe Rochet

Sci Total Environ· February 2024

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Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine.
Han Zhao, Junkai Xie, Shichen Wu, Xihui Zhao, Oscar F Sánchez, Jean-Christophe Rochet

Sci Total Environ· January 2024

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Effects of Neighboring Phosphorylation Events on the Affinities of pT181-Tau Antibodies.
Sehong Min, Rodrigo Mohallem, Uma K Aryal, Tamara L Kinzer-Ursem, Jean-Christophe Rochet

Anal Chem· December 2023

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Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.
Eduardo Ramirez, Susantha K Ganegamage, Sehong Min, Henika Patel, Adedayo Ogunware, Jean-Christophe Rochet

ACS Chem Neurosci· November 2023

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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Zhefu Que, Maria I Olivero-Acosta, Ian Chen, Jingliang Zhang, Kyle Wettschurack, Jean-Christophe Rochet

bioRxiv· October 2023

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Developmental Pb exposure increases AD risk via altered intracellular Ca homeostasis in hiPSC-derived cortical neurons.
Junkai Xie, Shichen Wu, Hailey Szadowski, Sehong Min, Yang Yang, Jean-Christophe Rochet

J Biol Chem· August 2023

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Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases.
Aswathy Chandran, Haley Jane Oliver, Jean-Christophe Rochet

Biology (Basel)· August 2023

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Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease.
Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Jean-Christophe Rochet

Antioxidants (Basel)· July 2023

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TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Jean-Christophe Rochet

Cells· June 2023

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