Publications by authors named "Jeffrey Toretsky"

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A Novel FLI1 Monoclonal Antibody Which Recognizes EWS::FLI1 with High Affinity Is Useful for Detecting Ewing Sarcoma.
Saravana P Selvanathan, Olivia O Lansinger, David V Allegakoen, Emma J W McGuire, Ashley R Gaffey, Jeffrey A Toretsky

Antibodies (Basel)· November 2025

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Open-Label, Multicenter, Phase I/II, First-in-Human Trial of TK216: A First-Generation EWS::FLI1 Fusion Protein Antagonist in Ewing Sarcoma.
Paul A Meyers, Noah Federman, Najat Daw, Peter M Anderson, Lara E Davis, Jeffrey A Toretsky

J Clin Oncol· November 2024

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Retraction: Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage.
Hae-June Lee, Changhwan Yoon, Benjamin Schmidt, Do Joong Park, Alexia Y Zhang, Jeffrey A Toretsky

Mol Cancer Ther· November 2024

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Correction: YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.
Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Jeffrey Toretsky

Oncotarget· February 2024

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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity.
Juntae Kwon, Jinmin Zhang, Boram Mok, Samuel Allsup, Chul Kim, Jeffrey Toretsky

Mol Cancer· December 2023

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Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity.
Kay Nakazawa, Taryn Shaw, Young K Song, Marilyn Kouassi-Brou, Anna Molotkova, Jeffrey A Toretsky

Cancer Res Commun· October 2023

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Widespread hypertranscription in aggressive human cancers.
Matthew Zatzman, Fabio Fuligni, Ryan Ripsman, Tannu Suwal, Federico Comitani, Jeffrey A Toretsky

Sci Adv· November 2022

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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
David S Shulman, Sarah B Whittle, Didier Surdez, Kelly M Bailey, Enrique de Álava, Jeffrey A Toretsky

NPJ Precis Oncol· September 2022

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Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.
Na Sun, Benjamin V Tran, Zishan Peng, Jing Wang, Ceng Zhang, Jeffrey A Toretsky

Adv Sci (Weinh)· May 2022

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Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.
Garrett T Graham, Saravana P Selvanathan, Stefan K Zöllner, Emily Stahl, Adam Shlien, Jeffrey A Toretsky

NAR Cancer· March 2022

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The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient.
Erica Rabinovich, Kelly Johnson-Arbor, Mariastella Serrano, Catherine Chao, Michael J Eblan, Jeffrey Toretsky

JPGN Rep· February 2022

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Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.
Handan Sevim, Haydar Çelik, Levent Düşünceli, Ceyda S Ceyhan, Anna Molotkova, Jeffrey A Toretsky

PLoS One· November 2021

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Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide.
Jatinder K Singh, Michael A Terao, Susmita Sarangi, Jennifer Toth, Jeffrey A Toretsky

Pediatr Blood Cancer· August 2021

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-Linked--Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.
Michael L Nosella, Maria Tereshchenko, Iva Pritišanac, P Andrew Chong, Jeffrey A Toretsky

J Am Chem Soc· August 2021

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Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Hyeongjwa Choi, Juntae Kwon, Min Soon Cho, Yifan Sun, Xiaofeng Zheng, Jeffrey Toretsky

Cancer Res· July 2021

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Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.
Stefan K Zöllner, James F Amatruda, Sebastian Bauer, Stéphane Collaud, Enrique de Álava, Jeffrey A Toretsky

J Clin Med· April 2021

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Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies.
Jiantong Dong, Ryan Y Zhang, Na Sun, Junhui Hu, Matthew D Smalley, Jeffrey A Toretsky

Adv Funct Mater· December 2020

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A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult.
Kyungmin Ko, Takashi Kitani, Brent T Harris, Amjad N Anaizi, David Solomon, Jeffrey Toretsky

Acta Neuropathol Commun· July 2020

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Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279.
Erin Conn, Sarah Hour, David Allegakoen, Garrett Graham, Jeff Petro, Jeffrey Toretsky

Mol Med Rep· March 2020

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EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.
Saravana P Selvanathan, Garrett T Graham, Alexander R Grego, Tabari M Baker, J Robert Hogg, Jeffrey A Toretsky

Nucleic Acids Res· October 2019

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The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents.
Filippo Spriano, Elaine Yee Lin Chung, Eugenio Gaudio, Chiara Tarantelli, Luciano Cascione, Jeffrey A Toretsky

Clin Cancer Res· August 2019

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Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.
Yan Ma, Michael Baltezor, Lian Rajewski, Jennifer Crow, Glenson Samuel, Jeffrey A Toretsky

J Mol Med (Berl)· July 2019

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Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Nathaniel D Anderson, Richard de Borja, Matthew D Young, Fabio Fuligni, Andrej Rosic, Jeffrey A Toretsky

Science· August 2018

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Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A Lawrence, Jeffrey A Toretsky

Nature· July 2018

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Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.
Kalliopi Tsafou, Anna Maria Katschnig, Branka Radic-Sarikas, Cornelia Noëlle Mutz, Kristiina Iljin, Jeffrey Toretsky

Oncotarget· July 2018

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