Publications by authors named "Jennifer Legac"

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Optimization of Prodiginines as Single-Dose Curative Antimalarials.
Amrendra Kumar, Yuexin Li, Xiaowei Zhang, Mahesh Gaddam, Diana Caridha, Jennifer Legac

J Med Chem· November 2025

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Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.
Matthew T Klope, Poulami Talukder, Brian R Blank, Sevil Chelebieva, Jun Chen, Jennifer Legac

Sci Adv· August 2025

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Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024.
Martin Okitwi, Stephen Orena, Patrick K Tumwebaze, Thomas Katairo, Yoweri Taremwa, Jennifer Legac

Nat Commun· August 2025

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Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites.
Amrendra Kumar, Yuexin Li, Xiaowei Zhang, Xiannu Jin, William E Dennis, Jennifer Legac

J Med Chem· June 2025

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Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Diana Caridha, Michael S Madejczyk, Jennifer Legac

J Med Chem· April 2025

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Changes in susceptibility of to antimalarial drugs in Uganda over time: 2019-2024.
Martin Okitwi, Stephen Orena, Patrick K Tumwebaze, Thomas Katairo, Yoweri Taremwa, Jennifer Legac

medRxiv· January 2025

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The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh isolates.
Martin Okitwi, Douglas A Shoue, Lisa A Checkley, Stephen Orena, Frida G Ceja, Jennifer Legac

Antimicrob Agents Chemother· December 2024

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susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan isolates.
Oriana Kreutzfeld, Stephen Orena, Martin Okitwi, Patrick K Tumwebaze, Oswald Byaruhanga, Jennifer Legac

Antimicrob Agents Chemother· September 2024

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Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study.
Michelle E Roh, Issaka Zongo, Alassane Haro, Liusheng Huang, Anyirékun Fabrice Somé, Jennifer Legac

J Infect Dis· October 2023

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Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
Melissa D Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niaré, Jennifer Legac

N Engl J Med· August 2023

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Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Oriana Kreutzfeld, Patrick K Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Jennifer Legac

Microbiol Spectr· June 2023

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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K Tumwebaze, Oswald Byaruhanga, Jennifer Legac

Antimicrob Agents Chemother· October 2022

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Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
Patrick K Tumwebaze, Melissa D Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Jennifer Legac

Nat Commun· October 2022

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The Multistage Antimalarial Compound Calxinin Perturbates Ca Homeostasis by Targeting a Unique Ion Channel.
Yash Gupta, Neha Sharma, Snigdha Singh, Jesus G Romero, Vinoth Rajendran, Jennifer Legac

Pharmaceutics· June 2022

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Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
Oriana Kreutzfeld, Patrick K Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Martin Okitwi, Jennifer Legac

J Infect Dis· February 2022

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Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
Oriana Kreutzfeld, Stephanie A Rasmussen, Aarti A Ramanathan, Patrick K Tumwebaze, Oswald Byaruhanga, Jennifer Legac

Antimicrob Agents Chemother· September 2021

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Drug susceptibility of in eastern Uganda: a longitudinal phenotypic and genotypic study.
Patrick K Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, Stephen Orena, Jennifer Legac

Lancet Microbe· September 2021

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Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.
Marvin Duvalsaint, Melissa D Conrad, Stephen Tukwasibwe, Patrick K Tumwebaze, Jennifer Legac

Malar J· June 2021

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Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.
Victor Asua, Melissa D Conrad, Ozkan Aydemir, Marvin Duvalsaint, Jennifer Legac

J Infect Dis· March 2021

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Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.
Brian R Blank, Ryan L Gonciarz, Poulami Talukder, Jiri Gut, Jennifer Legac

ACS Infect Dis· July 2020

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Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
Alexander Stoye, Annette Juillard, Arthur H Tang, Jennifer Legac, Jiri Gut

J Med Chem· June 2019

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Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.
Victor Asua, Joanna Vinden, Melissa D Conrad, Jennifer Legac, Simon P Kigozi

Antimicrob Agents Chemother· March 2019

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Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.
Erika Wallender, Nan Zhang, Melissa Conrad, Abel Kakuru, Mary Muhindo, Jennifer Legac

Antimicrob Agents Chemother· February 2019

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Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.
Melissa D Conrad, Daniel Mota, Marissa Foster, Stephen Tukwasibwe, Jennifer Legac

J Infect Dis· November 2017

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Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.
Ebere Sonoiki, Christian Nsanzabana, Jennifer Legac, Kirthana M V Sindhe, Joseph DeRisi

Antimicrob Agents Chemother· January 2017

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