Publications by authors named "Jennifer M Spangle"

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Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.
Kirti Sad, Dorelle V Fawwal, Celina Y Jones, Emily J Hill, Katie T Skinner, Jennifer M Spangle

NAR Cancer· March 2025

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Dynamic Mapping of the Methylproteome Using a Chemoenzymatic Approach.
Jonathan Farhi, Benjamin Emenike, Richard S Lee, Kirti Sad, Dorelle V Fawwal, Jennifer M Spangle

J Am Chem Soc· March 2025

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Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype.
Kirti Sad, Celina Y Jones, Dorelle V Fawwal, Emily J Hill, Katie Skinner, Jennifer M Spangle

bioRxiv· August 2024

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Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jennifer M Spangle

Commun Biol· April 2024

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Tunable fluorescent probes for detecting aldehydes in living systems.
Rachel Wills, Rajendra Shirke, Hannah Hrncir, John M Talbott, Kirti Sad, Jennifer M Spangle

Chem Sci· March 2024

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Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model.
Xinran Zhang, Dorelle V Fawwal, Jennifer M Spangle, Anita H Corbett, Celina Y Jones

J Fungi (Basel)· December 2023

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Identification of ligand-receptor pairs that drive human astrocyte development.
Anna J Voss, Samantha N Lanjewar, Maureen M Sampson, Alexia King, Emily J Hill, Jennifer M Spangle

Nat Neurosci· August 2023

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Chemical sensors for imaging total cellular aliphatic aldehydes in live cells.
Rachel Wills, Jonathan Farhi, Patrick Czabala, Sophia Shahin, Jennifer M Spangle

Chem Sci· August 2023

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Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response.
Richard Sean Lee, Kirti Sad, Dorelle V Fawwal, Jennifer Marie Spangle

Cancers (Basel)· August 2023

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Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor-positive Breast Cancer.
Robert B Jones, Jonathan Farhi, Miranda Adams, Kiran K Parwani, Garrett W Cooper, Jennifer M Spangle

Cancer Res Commun· December 2022

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Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
Miyoung Lee, Delaney K Geitgey, Jamie A G Hamilton, Jeremy M Boss, Christopher D Scharer, Jennifer M Spangle

Front Cell Dev Biol· August 2022

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A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.
Laramie D Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G Choi, Jennifer M Spangle

G3 (Bethesda)· July 2022

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Medulloblastoma and the DNA Damage Response.
Leon F McSwain, Kiran K Parwani, Shubin W Shahab, Dolores Hambardzumyan, Tobey J MacDonald, Jennifer M Spangle

Front Oncol· June 2022

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Practical advice for mentoring and supporting faculty colleagues in STEM fields: Views from mentor and mentee perspectives.
Jennifer M Spangle, Homa Ghalei, Anita H Corbett

J Biol Chem· September 2021

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PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.
Jennifer M Spangle, Thanh Von, Dean C Pavlick, Arina Khotimsky, Jean J Zhao

Proc Natl Acad Sci U S A· September 2020

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The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.
Jennifer M Spangle, Thomas M Roberts, Jean J Zhao

Biochim Biophys Acta Rev Cancer· August 2017

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Epigenetic regulation of RTK signaling.
Jennifer M Spangle, Thomas M Roberts

J Mol Med (Berl)· August 2017

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PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.
Lauren M Thorpe, Jennifer M Spangle, Carolynn E Ohlson, Hailing Cheng, Thomas M Roberts

Proc Natl Acad Sci U S A· July 2017

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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
Jennifer M Spangle, Koen M Dreijerink, Anna C Groner, Hailing Cheng, Carolynn E Ohlson

Cell Rep· June 2016

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The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.
Jordan M Meyers, Jennifer M Spangle, Karl Munger

J Virol· April 2013

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The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species.
Jennifer M Spangle, Karl Munger

PLoS Pathog· March 2013

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Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.
Jennifer M Spangle, Nayana Ghosh-Choudhury, Karl Munger

J Virol· July 2012

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Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
Orit Rozenblatt-Rosen, Rahul C Deo, Megha Padi, Guillaume Adelmant, Michael A Calderwood, Jennifer M Spangle

Nature· July 2012

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The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.
Jennifer M Spangle, Karl Münger

J Virol· September 2010

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Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: is autophagy an "Achilles' heel" of human cancers?
Xiaobo Zhou, Jennifer M Spangle, Karl Münger

Autophagy· May 2009

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