Publications by authors named "Jeremy I Levin"

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Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.
Joshua C Horan, Daniel Kuzmich, Pingrong Liu, Darren DiSalvo, John Lord, Jeremy I Levin

Bioorg Med Chem Lett· January 2016

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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Zhong Li, Russell G Dushin, Thomas Nittoli, Jeremy I Levin

Bioorg Med Chem Lett· August 2011

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli, Jeremy I Levin

Bioorg Med Chem Lett· June 2011

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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Jennifer M Golas, Jeremy I Levin

Bioorg Med Chem Lett· June 2011

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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli, Jeremy I Levin

Bioorg Med Chem Lett· April 2011

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Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity.
Xiaolun Wang, Dan M Berger, Edward J Salaski, Nancy Torres, Minu Dutia, Jeremy I Levin

J Med Chem· November 2010

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Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Xiaolun Wang, Dan M Berger, Edward J Salaski, Nancy Torres, Yongbo Hu, Jeremy I Levin

Bioorg Med Chem Lett· December 2009

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Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Dan M Berger, Nancy Torres, Minu Dutia, Dennis Powell, Greg Ciszewski, Jeremy I Levin

Bioorg Med Chem Lett· December 2009

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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Martin J Di Grandi, Dan M Berger, Darrin W Hopper, Chunchun Zhang, Minu Dutia, Jeremy I Levin

Bioorg Med Chem Lett· December 2009

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3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Wei Li, Yonghan Hu, Jianchang Li, Jennifer R Thomason, Dianne DeVincentis, Jeremy I Levin

Bioorg Med Chem Lett· August 2009

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Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Chunchun Zhang, Frank Lovering, Mark Behnke, Arie Zask, Vincent Sandanayaka, Jeremy I Levin

Bioorg Med Chem Lett· July 2009

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Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Kaapjoo Park, Ariamala Gopalsamy, Alexis Aplasca, John W Ellingboe, Weixin Xu, Jeremy I Levin

Bioorg Med Chem· June 2009

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Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
Edward J Salaski, Girija Krishnamurthy, Wei-Dong Ding, Ker Yu, Shabana S Insaf, Jeremy I Levin

J Med Chem· April 2009

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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Lourdes Toral-Barza, Wei-Guo Zhang, Xinyi Huang, Leonard A McDonald, Edward J Salaski, Jeremy I Levin

Mol Cancer Ther· November 2007

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Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Adrian Huang, Diane Joseph-McCarthy, Frank Lovering, Linhong Sun, Weiheng Wang, Jeremy I Levin

Bioorg Med Chem· September 2007

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A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production.
Qin Wang, Yuhua Zhang, J Perry Hall, Lih-Ling Lin, Uma Raut, Jeremy I Levin

J Pharmacol Toxicol Methods· August 2007

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Identification of potent and selective TACE inhibitors via the S1 pocket.
Jeffrey S Condon, Diane Joseph-McCarthy, Jeremy I Levin, Henry-Georges Lombart, Frank E Lovering

Bioorg Med Chem Lett· January 2007

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Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Kaapjoo Park, Alexis Aplasca, Mila T Du, LinHong Sun, Yi Zhu, Jeremy I Levin

Bioorg Med Chem Lett· August 2006

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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Yonghan Hu, Jason S Xiang, Martin J DiGrandi, Xuemei Du, Manus Ipek, Jeremy I Levin

Bioorg Med Chem· December 2005

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Synthesis and SAR of highly selective MMP-13 inhibitors.
Jianchang Li, Thomas S Rush, Wei Li, Dianne DeVincentis, Xuemei Du, Jeremy I Levin

Bioorg Med Chem Lett· November 2005

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Identification of potent and selective MMP-13 inhibitors.
Junjun Wu, Thomas S Rush, Rajeev Hotchandani, Xuemei Du, Mary Geck, Jeremy I Levin

Bioorg Med Chem Lett· September 2005

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The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
Jeremy I Levin

Curr Top Med Chem· January 2005

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Sulfonate ester hydroxamic acids as potent and selective inhibitors of TACE enzyme.
Jeremy I Levin, Mila T Du

Drug Des Discov· December 2004

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Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Aranapakam M Venkatesan, Jamie M Davis, George T Grosu, Jannie Baker, Arie Zask, Jeremy I Levin

J Med Chem· December 2004

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Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
Jeremy I Levin, Frances C Nelson, Efren Delos Santos, Mila T Du, Gloria MacEwan

Bioorg Med Chem Lett· August 2004

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