Publications by authors named "Jerri Rook"

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Discovery of VU6052254: A Novel, Potent M Positive Allosteric Modulator.
Julie L Engers, Joseph D Bungard, Christopher C Presley, Irene Zagol-Ikapitte, Katherine J Watson, Jerri M Rook

ACS Chem Neurosci· December 2025

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Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391).
Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, Takahiro Mori, Tomoyuki Shono, Jerri M Rook

J Med Chem· November 2025

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Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants.
Alexander C Conley, Alexandra P Key, Jennifer U Blackford, Jason K Russell, Kimberly M Albert, Jerri M Rook

Alzheimers Res Ther· July 2025

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Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome.
Hong-Wei Dong, Kelly Weiss, Jonathan W Dickerson, Mac J Meadows, Irene Zagol-Ikapitte, Jerri M Rook

J Pharmacol Exp Ther· June 2025

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Discovery of Thieno[3,2-]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Katherine E Crocker, Scott H Henderson, Rory A Capstick, David L Whomble, Aaron M Bender, Jerri M Rook

ACS Med Chem Lett· May 2025

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Application of Deuterium in an M Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422.
Julie L Engers, Jinming Li, Changho Han, Madeline F Long, Alison R Gregro, Jerri M Rook

ACS Chem Neurosci· April 2025

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Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of the Muscarinic M 1 Positive Allosteric Modulator VU0467319 for Alzheimer's disease: A Single Ascending-Dose Study in Healthy Participants.
Alexander C Conley, Alexandra P Key, Jennifer U Blackford, Jason K Russell, Kimberly M Albert, Jerri M Rook

Res Sq· April 2025

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Further Optimization of the mGlu PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685.
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, Trevor A Trombley, Paul K Spearing, Jerri M Rook

ACS Chem Neurosci· February 2025

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Discovery of VU0467319: an M Positive Allosteric Modulator Candidate That Advanced into Clinical Trials.
Michael S Poslunsey, Michael R Wood, Changho Han, Shaun R Stauffer, Joseph D Panarese, Jerri M Rook

ACS Chem Neurosci· January 2025

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Discovery of VU6024578/BI02982816: An mGlu Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models.
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, Trevor A Trombley, Anthony F Nastase, Jerri M Rook

J Med Chem· December 2024

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Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, Miranda L Ledyard, Aaron M Bender, Jerri M Rook

ACS Med Chem Lett· December 2024

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Discovery of VU6007496: Challenges in the Development of an M Positive Allosteric Modulator Backup Candidate.
Julie L Engers, Katrina A Bollinger, Rory A Capstick, Madeline F Long, Aaron M Bender, Jerri M Rook

ACS Chem Neurosci· September 2024

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM).
Julie L Engers, Logan A Baker, Sichen Chang, Vincent B Luscombe, Alice L Rodriguez, Jerri M Rook

ACS Chem Neurosci· September 2024

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Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift.
Mohammed N Tantawy, J Oliver McIntyre, Fiona Yull, M Wade Calcutt, Dmitry S Koktysh, Jerri M Rook

Cancer Med· February 2024

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The Cell Permeant Phosphopetpide mimetic of VASP Alleviates Motor Function Deficits After Experimental Subarachnoid Hemorrhage.
Madeleine Morelli, Jamie Adcock, Tsz Wing Yim, Jerri Rook, J Mocco

J Mol Neurosci· January 2024

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Development of a Selective and High Affinity Radioligand, [H]VU6013720, for the M Muscarinic Receptor.
Aidong Qi, Haley E Kling, Natasha Billard, Alice L Rodriguez, Li Peng, Jerri M Rook

Mol Pharmacol· November 2023

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Development of a Peripherally Restricted 5-HT Partial Agonist for Treatment of Pulmonary Arterial Hypertension.
Michael S Valentine, Aaron M Bender, Sheila Shay, Krista C Paffenroth, Santhi Gladson, Jerri M Rook

JACC Basic Transl Sci· October 2023

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M muscarinic acetylcholine receptor.
Aaron M Bender, Trever R Carter, Matthew Spock, Alice L Rodriguez, Jonathan W Dickerson, Jerri M Rook

Bioorg Med Chem Lett· January 2022

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Discovery of "Molecular Switches" within a Series of mGlu Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with Activity, Derived from an M PAM Chemotype.
Lisa Barbaro, Alice L Rodriguez, Ashlyn N Blevins, Jonathan W Dickerson, Natasha Billard, Jerri L Rook

ACS Bio Med Chem Au· December 2021

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Discovery of VU6028418: A Highly Selective and Orally Bioavailable M Muscarinic Acetylcholine Receptor Antagonist.
Matthew Spock, Trever R Carter, Katrina A Bollinger, Changho Han, Logan A Baker, Jerri M Rook

ACS Med Chem Lett· August 2021

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Discovery of the First Selective M Muscarinic Acetylcholine Receptor Antagonists with Antiparkinsonian and Antidystonic Efficacy.
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, Daniel J Foster, Aidong Qi, Jerri M Rook

ACS Pharmacol Transl Sci· August 2021

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Discovery and optimization of a novel CNS penetrant series of mGlu PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.
Caitlin N Kent, Mark G Fulton, Kaylee J Stillwell, Jonathan W Dickerson, Matthew T Loch, Jerri L Rook

Bioorg Med Chem Lett· April 2021

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A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
Nicole M Fisher, Aqeela AlHashim, Aditi B Buch, Hana Badivuku, Manar M Samman, Jerri M Rook

JCI Insight· February 2021

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Biased M receptor-positive allosteric modulators reveal role of phospholipase D in M-dependent rodent cortical plasticity.
Sean P Moran, Zixiu Xiang, Catherine A Doyle, James Maksymetz, Xiaohui Lv, Jerri M Rook

Sci Signal· December 2019

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VU6007477, a Novel M PAM Based on a Pyrrolo[2,3-]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events.
Julie L Engers, Elizabeth S Childress, Madeline F Long, Rory A Capstick, Vincent B Luscombe, Jerri M Rook

ACS Med Chem Lett· September 2018

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