Publications by authors named "Rory A Capstick"

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Discovery of Pre-Clinical Candidate /: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy.
Julie L Engers, Sean R Bollinger, Alison R Gregro, Rory A Capstick, Paul K Spearing

ACS Chem Neurosci· June 2025

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Discovery of Thieno[3,2-]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Katherine E Crocker, Scott H Henderson, Rory A Capstick, David L Whomble, Aaron M Bender

ACS Med Chem Lett· May 2025

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Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, Miranda L Ledyard, Aaron M Bender

ACS Med Chem Lett· December 2024

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Discovery of VU6007496: Challenges in the Development of an M Positive Allosteric Modulator Backup Candidate.
Julie L Engers, Katrina A Bollinger, Rory A Capstick, Madeline F Long, Aaron M Bender

ACS Chem Neurosci· September 2024

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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M Muscarinic Acetylcholine Receptor.
Jinming Li, Douglas L Orsi, Julie L Engers, Madeline F Long, Rory A Capstick

J Med Chem· August 2024

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Discovery of VU6008677: A Structurally Distinct Tricyclic M Positive Allosteric Modulator with Improved CYP450 Profile.
Rory A Capstick, Sean R Bollinger, Julie L Engers, Madeline F Long, Sichen Chang

ACS Med Chem Lett· August 2024

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Discovery of a potent M antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists.
Rory A Capstick, David Whomble, Douglas L Orsi, Andrew S Felts, Alice L Rodriguez

Bioorg Med Chem Lett· November 2022

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Development of : A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
Aaron T Garrison, Douglas L Orsi, Rory A Capstick, David Whomble, Jinming Li

J Med Chem· April 2022

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Discovery of structurally distinct tricyclic M positive allosteric modulator (PAM) chemotypes - Part 2.
Madeline F Long, Rory A Capstick, Paul K Spearing, Julie L Engers, Alison R Gregro

Bioorg Med Chem Lett· December 2021

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DARK Classics in Chemical Neuroscience: Gamma-Hydroxybutyrate (GHB).
Trevor A Trombley, Rory A Capstick, Craig W Lindsley

ACS Chem Neurosci· December 2020

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The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate.
Joseph D Panarese, Darren W Engers, Yong-Jin Wu, Jason M Guernon, Aspen Chun, Rory A Capstick

Bioorg Med Chem Lett· January 2019

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VU6007477, a Novel M PAM Based on a Pyrrolo[2,3-]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events.
Julie L Engers, Elizabeth S Childress, Madeline F Long, Rory A Capstick, Vincent B Luscombe

ACS Med Chem Lett· September 2018

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