Publications by authors named "Yong-Jin Wu"

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C
Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols.
Michael J Strauss, Kaylee X Liu, Megan E Greaves, Jakob C Dahl, Seoung-Tae Kim, Yong-Jin Wu

J Am Chem Soc· July 2024

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5-Bromo-2-chloro-4-fluoro-3-iodopyridine as a Halogen-rich Intermediate for the Synthesis of Pentasubstituted Pyridines.
Yong-Jin Wu, Gerard J Porter, David B Frennesson, Mark G Saulnier

J Org Chem· March 2022

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Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Yong-Jin Wu, Nicholas A Meanwell

J Med Chem· July 2021

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Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property.
Yong-Jin Wu, Yan-Nan Song, Xiao-Rui Geng, Fei Ma, Li-Hua Mo

Int J Biol Sci· November 2020

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Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.
Yunhui Zhang, Kenneth M Boy, Yong-Jin Wu, Antonio Ramirez, Jeremy H Toyn

Bioorg Med Chem Lett· November 2020

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Survivin facilitates T-helper 2-biased inflammation in the airway.
Jin-Mei Xue, Mei-Zhen Zhao, Fei Ma, Shan-Shan Li, Li-Hua Mo, Yong-Jin Wu

Int Forum Allergy Rhinol· June 2019

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3-Methyl-4-nitrophenol triggers nasal allergy by modulating dendritic cell properties.
Xiao-Yu Liu, Yong-Jin Wu, Li-Juan Song, Xian-Hai Zeng, Shuai Wang

J Allergy Clin Immunol· April 2019

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Discovery of VU2957 (Valiglurax): An mGlu Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease.
Joseph D Panarese, Darren W Engers, Yong-Jin Wu, Joanne J Bronson, John E Macor

ACS Med Chem Lett· March 2019

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.
Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, Li Xu, Yunhui Zhang, Yong-Jin Wu

ACS Med Chem Lett· March 2019

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Discovery of new indole-based acylsulfonamide Na1.7 inhibitors.
Yong-Jin Wu, Brian Venables, Jason Guernon, Jie Chen, Sing-Yuen Sit

Bioorg Med Chem Lett· February 2019

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The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate.
Joseph D Panarese, Darren W Engers, Yong-Jin Wu, Jason M Guernon, Aspen Chun

Bioorg Med Chem Lett· January 2019

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Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis.
Jian-Bo Shao, Xiang-Qian Luo, Yong-Jin Wu, Mao-Gang Li, Jing-Yi Hong

Int Forum Allergy Rhinol· November 2018

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Bcl2L12 plays a critical role in the development of intestinal allergy.
Bai-Sui Feng, Yong-Jin Wu, Jing-Yi Hong, Xiao-Rui Geng, Jiang-Qi Liu

Immunol Lett· November 2018

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Bcl2L12 mediates effects of protease-activated receptor-2 on the pathogenesis of Th2-dominated responses of patients with ulcerative colitis.
Bai-Sui Feng, Yong-Jin Wu, Xian-Hai Zeng, Dian Yu, Zhi-Qiang Liu

Arch Biochem Biophys· November 2018

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B cell lymphoma-2-like protein-12 association with T-helper 2 inflammation in chronic rhinosinusitis with allergy.
Yun-Fang An, Yong-Jin Wu, Xian-Hai Zeng, Li-Juan Song, Fei Ma

Int Forum Allergy Rhinol· November 2018

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Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu positive allosteric modulators that mitigate CYP1A2 induction liability.
Darren W Engers, Sean R Bollinger, Julie L Engers, Joseph D Panarese, Megan M Breiner, Yong-Jin Wu

Bioorg Med Chem Lett· August 2018

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Discovery of morpholine-based aryl sulfonamides as Na1.7 inhibitors.
Yong-Jin Wu, Jason Guernon, Andrea McClure, Brian Venables, Ramkumar Rajamani

Bioorg Med Chem Lett· March 2018

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Discovery of non-zwitterionic aryl sulfonamides as Na1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Yong-Jin Wu, Jason Guernon, Andrea McClure, Guanglin Luo, Ramkumar Rajamani

Bioorg Med Chem· October 2017

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Development of New Benzenesulfonamides As Potent and Selective Na1.7 Inhibitors for the Treatment of Pain.
Yong-Jin Wu, Jason Guernon, Jianliang Shi, Jonathan Ditta, Kevin J Robbins

J Med Chem· March 2017

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Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Yong-Jin Wu, Jason Guernon, Ramkumar Rajamani, Jeremy H Toyn, Michael K Ahlijanian

Bioorg Med Chem Lett· December 2016

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Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
Yong-Jin Wu, Jason Guernon, Jianliang Shi, Lawrence Marcin, Mendi Higgins

J Med Chem· September 2016

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Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3-d][1,3]thiazinamines from Enones and Thiourea.
Yong-Jin Wu, Jason Guernon, Hyunsoo Park, Lorin A Thompson

J Org Chem· April 2016

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Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators.
Yong-Jin Wu, Yunhui Zhang, Jeremy H Toyn, John E Macor, Lorin A Thompson

Bioorg Med Chem Lett· March 2016

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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.
Yong-Jin Wu, Jason Guernon, Fukang Yang, Lawrence Snyder, Jianliang Shi

ACS Med Chem Lett· March 2016

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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE).
Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, Yunhui Zhang, Joe Shi

Bioorg Med Chem Lett· November 2015

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