Publications by authors named "Brian Venables"

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Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans.
Sing-Yuen Sit, Yan Chen, Jie Chen, Brian L Venables, Jacob J Swidorski

ACS Med Chem Lett· November 2024

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Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937.
Brian McAuliffe, Paul Falk, Jie Chen, Yan Chen, Sing-Yuen Sit, Brian Venables

Viruses· September 2024

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Synthesis, Structure-Activity Relationships, and Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
Richard A Hartz, Li Xu, Sing-Yuen Sit, Jie Chen, Brian L Venables

J Med Chem· December 2022

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The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J Swidorski, Brian L Venables

J Med Chem· September 2022

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Discovery of new indole-based acylsulfonamide Na1.7 inhibitors.
Yong-Jin Wu, Brian Venables, Jason Guernon, Jie Chen, Sing-Yuen Sit

Bioorg Med Chem Lett· February 2019

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Alicia Regueiro-Ren, Jacob J Swidorski, Zheng Liu, Yan Chen, Ny Sin, Brian L Venables

J Med Chem· August 2018

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Brian L Venables, Ny Sin, Alan Xiangdong Wang, Li-Qiang Sun, Yong Tu

Bioorg Med Chem Lett· June 2018

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The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Yan Chen, Sing-Yuen Sit, Jie Chen, Jacob J Swidorski, Zheng Liu, Brian L Venables

Bioorg Med Chem Lett· May 2018

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Discovery of morpholine-based aryl sulfonamides as Na1.7 inhibitors.
Yong-Jin Wu, Jason Guernon, Andrea McClure, Brian Venables, Ramkumar Rajamani

Bioorg Med Chem Lett· March 2018

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
Li-Qiang Sun, Eric Mull, Barbara Zheng, Stanley D'Andrea, Qian Zhao, Brian L Venables

J Med Chem· September 2016

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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Zhufang Li, Sharon Zhang, Brian L Venables

Antimicrob Agents Chemother· July 2016

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Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
Alicia Regueiro-Ren, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Brian L Venables

ACS Med Chem Lett· June 2016

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Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Jacob J Swidorski, Zheng Liu, Sing-Yuen Sit, Jie Chen, Yan Chen, Brian L Venables

Bioorg Med Chem Lett· April 2016

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Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Alan Xiangdong Wang, Andrew C Good, Li-Qiang Sun, Keith D Combrink, Brian L Venables

J Med Chem· March 2014

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The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Li-Qiang Sun, Alan Xiangdong Wang, Jie Chen, Ny Sin, Brian L Venables

J Med Chem· March 2014

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15N chemical shifts of a series of isatin oxime ethers and their corresponding nitrone isomers.
Xiaohong Liu, Xiaohua Stella Huang, Ny Sin, Brian L Venables, Vikram Roongta

Magn Reson Chem· November 2010

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Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Ny Sin, Brian L Venables, Keith D Combrink, H Belgin Gulgeze, Kuo-Long Yu

Bioorg Med Chem Lett· August 2009

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Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Kuo-Long Yu, Ny Sin, Rita L Civiello, X Alan Wang, Keith D Combrink, Brian L Venables

Bioorg Med Chem Lett· February 2007

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Orally active fusion inhibitor of respiratory syncytial virus.
Christopher Cianci, Kuo-Long Yu, Keith Combrink, Ny Sin, Bradley Pearce, Brian Venables

Antimicrob Agents Chemother· February 2004

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Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.
David Sperandio, Anthony R Gangloff, Joane Litvak, Richard Goldsmith, Jason M Hataye, Brian L Venables

Bioorg Med Chem Lett· November 2002

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