Publications by authors named "Jerry W Cubbage"

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Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
Robert O Hughes, D Joseph Rogier, E Jon Jacobsen, John K Walker, Alan Macinnes, Jerry W Cubbage

J Med Chem· March 2010

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Robert O Hughes, John K Walker, D Joseph Rogier, Steve E Heasley, Rhadika M Blevis-Bal, Jerry W Cubbage

Bioorg Med Chem Lett· September 2009

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Robert O Hughes, John K Walker, Jerry W Cubbage, Yvette M Fobian, D Joseph Rogier

Bioorg Med Chem Lett· August 2009

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Dafydd R Owen, John K Walker, E Jon Jacobsen, John N Freskos, Robert O Hughes, Jerry W Cubbage

Bioorg Med Chem Lett· August 2009

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A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors.
Scott D Larsen, Carl F Stachew, Paula M Clare, Jerry W Cubbage, Karen L Leach

Bioorg Med Chem Lett· October 2003

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