Publications by authors named "Scott D Larsen"

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Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.
Santiago Panesso-Gómez, Alexander J Cole, Alyssa Wield, Vivian I Anyaeche, Jaynish Shah, Scott D Larsen

bioRxiv· November 2024

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Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes.
Cyrus Takahashi, Mikhail Chtcherbinine, Brandt C Huddle, Michael W Wilson, Timothy Emmel, Scott D Larsen

Chem Biol Interact· March 2024

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Prevention of bleomycin-induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway.
Kendell M Pawelec, Megan Varnum, Jack R Harkema, Bruce Auerbach, Scott D Larsen

Pharmacol Res Perspect· December 2022

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Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.
Nan Wang, Feng Qi, Haqing Yu, Bryan D Yestrepsky, Scott D Larsen

PLoS One· August 2021

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Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore.
Scott J Barraza, Janice A Sindac, Craig J Dobry, Philip C Delekta, Pil H Lee, Scott D Larsen

Bioorg Med Chem Lett· August 2021

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AC2P20 selectively kills at acidic pH by depleting free thiols.
Shelby J Dechow, Garry B Coulson, Michael W Wilson, Scott D Larsen, Robert B Abramovitch

RSC Adv· June 2021

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Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Brandt C Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D Buchman, Cyrus Takahashi, Scott D Larsen

Eur J Med Chem· February 2021

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Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3.
Michael W Wilson, Liming Shu, Vania Hinkovska-Galcheva, Yafei Jin, Walajapet Rajeswaran, Scott D Larsen

ACS Chem Neurosci· October 2020

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Discovery and Optimization of Triazine Nitrile Inhibitors of Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Jeffery D Zwicker, David Smith, Alfredo J Guerra, Jacob R Hitchens, Nicole Haug, Scott D Larsen

ACS Chem Neurosci· August 2020

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A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the -Opioid Receptor.
Renee A Bouley, Zara Y Weinberg, Helen V Waldschmidt, Yu-Chen Yen, Scott D Larsen

Mol Pharmacol· June 2020

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Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.
Rachel A Rowlands, M Claire Cato, Helen V Waldschmidt, Renee A Bouley, Qiuyan Chen, Scott D Larsen

ACS Med Chem Lett· December 2019

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Correction to "Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine".
Helen V Waldschmidt, Kristoff T Homan, Marilyn C Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Scott D Larsen

J Med Chem· June 2019

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Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.
Xinmin Gan, Michael W Wilson, Tyler S Beyett, Bo Wen, Duxin Sun, Scott D Larsen

J Labelled Comp Radiopharm· May 2019

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5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.
Dylan J Kahl, Kim M Hutchings, Erika Mathes Lisabeth, Andrew J Haak, Jeffrey R Leipprandt, Scott D Larsen

J Med Chem· May 2019

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Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds.
Erika M Lisabeth, Dylan Kahl, Indiwari Gopallawa, Sarah E Haynes, Sean A Misek, Scott D Larsen

ACS Pharmacol Transl Sci· April 2019

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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Ilana Chefetz, Edward Grimley, Kun Yang, Linda Hong, Ekaterina V Vinogradova, Scott D Larsen

Cell Rep· March 2019

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Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes.
Megan E Dumas, Geng-Yuan Chen, Nicole D Kendrick, George Xu, Scott D Larsen

Bioorg Med Chem Lett· January 2019

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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.
Steven P Tanis, Jerry R Colca, Timothy T Parker, Gerald D Artman, Scott D Larsen

Bioorg Med Chem· December 2018

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In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis.
Aristides D Tagalakis, Shivam Madaan, Scott D Larsen, Richard R Neubig, Peng T Khaw

J Nanobiotechnology· November 2018

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Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Brandt C Huddle, Edward Grimley, Cameron D Buchman, Mikhail Chtcherbinine, Bikash Debnath, Scott D Larsen

J Med Chem· October 2018

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Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.
Jeffery D Zwicker, Nicolas A Diaz, Alfredo J Guerra, Paul D Kirchhoff, Bo Wen, Scott D Larsen

Bioorg Med Chem Lett· June 2018

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Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.
Hannah M Stoveken, Scott D Larsen, Alan V Smrcka, Gregory G Tall

Mol Pharmacol· May 2018

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Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.
Helen V Waldschmidt, Renee Bouley, Paul D Kirchhoff, Pil Lee, John J G Tesmer, Scott D Larsen

Bioorg Med Chem Lett· May 2018

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Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Renee Bouley, Helen V Waldschmidt, M Claire Cato, Alessandro Cannavo, Jianliang Song, Scott D Larsen

Mol Pharmacol· December 2017

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Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.
Michael W Beck, Jeffrey S Derrick, Jong-Min Suh, Mingeun Kim, Kyle J Korshavn, Scott D Larsen

ChemMedChem· November 2017

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