Publications by authors named "Jessica A Bush"

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Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG) Degrader in Myotonic Dystrophy.
Quentin M R Gibaut, Jessica A Bush, Yuquan Tong, Jared T Baisden, Amirhossein Taghavi

ACS Cent Sci· July 2023

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Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.
Quentin M R Gibaut, Yoshihiro Akahori, Jessica A Bush, Amirhossein Taghavi, Toru Tanaka

J Am Chem Soc· December 2022

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A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(GC) in c9ALS/FTD via the nuclear RNA exosome.
Jessica A Bush, Samantha M Meyer, Rita Fuerst, Yuquan Tong, Yue Li

Proc Natl Acad Sci U S A· November 2022

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A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.
Andrei Ursu, Jared T Baisden, Jessica A Bush, Amirhossein Taghavi, Shruti Choudhary

ACS Chem Neurosci· November 2021

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Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(GC) repeat expansion in vitro and in vivo ALS models.
Jessica A Bush, Haruo Aikawa, Rita Fuerst, Yue Li, Andrei Ursu

Sci Transl Med· October 2021

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Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.
Jessica A Bush, Christopher C Williams, Samantha M Meyer, Yuquan Tong, Hafeez S Haniff

ACS Chem Biol· July 2021

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Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.
Andrei Ursu, Kye Won Wang, Jessica A Bush, Shruti Choudhary, Jonathan L Chen

ACS Chem Biol· December 2020

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