Publications by authors named "Jiajun Yap"

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Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold.
Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Yoon Sim Yap

Theranostics· May 2025

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BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.
Jiajun Yap, Jimin Yuan, Wan Hwa Ng, Gao Bin Chen, Yuen Rong M Sim

Mol Cancer· August 2023

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The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop.
Jiajun Yap, R N V Krishna Deepak, Zizi Tian, Wan Hwa Ng, Kah Chun Goh

Sci Adv· June 2021

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Drug resistance in targeted cancer therapies with RAF inhibitors.
Ufuk Degirmenci, Jiajun Yap, Yuen Rong M Sim, Shiru Qin, Jiancheng Hu

Cancer Drug Resist· June 2021

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The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.
Jimin Yuan, Xiaoduo Dong, Jiajun Yap, Jiancheng Hu

J Hematol Oncol· August 2020

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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods.
Jiajun Yap, Jimin Yuan, Zi Heng Tee, Xuchao Huang, Wan Hwa Ng

J Vis Exp· July 2019

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The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.
Jimin Yuan, Wan Hwa Ng, Paula Y P Lam, Yu Wang, Hongping Xia, Jiajun Yap

Oncogene· October 2018

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Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.
Jimin Yuan, Wan Hwa Ng, Zizi Tian, Jiajun Yap, Manuela Baccarini

Sci Signal· October 2018

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The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.
Jimin Yuan, Wan Hwa Ng, Jiajun Yap, Brandon Chia, Xuchao Huang

J Biol Chem· September 2018

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