Publications by authors named "Yoon Sim Yap"

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Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA.
Hanaé Carrié, Ngak Leng Sim, Pui Mun Wong, Anna Gan, Yi Ting Lau, Yoon Sim Yap

Nat Commun· December 2025

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Evaluating the impact of relative dose intensity on efficacy of trastuzumab deruxtecan for metastatic breast cancer in the real-world clinical setting.
Han Yi Lee, Vivianne Shih, Jack Junjie Chan, Shun Zi Liong, Ryan Shea Ying Cong Tan, Yoon Sim Yap

Ann Acad Med Singap· August 2025

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Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold.
Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Yoon Sim Yap

Theranostics· May 2025

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Risking arm lymphedema in more than a hundred patients to benefit one patient-is it worth it?
Geok Hoon Lim, Yoon-Sim Yap, Rui Jun Lim, Lester Chee Hao Leong

Gland Surg· April 2025

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A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths.
Guanhua Zhu, Chowdhury Rafeed Rahman, Victor Getty, Denis Odinokov, Probhonjon Baruah, Yoon Sim Yap

Nat Biomed Eng· March 2025

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Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Versus Combination Chemotherapy in Premenopausal Women With Clinically Aggressive Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer.
Yen-Shen Lu, Eznal Izwadi Bin Mohd Mahidin, Hamdy Azim, Yesim Eralp, Yoon Sim Yap

J Clin Oncol· August 2024

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A phase 3 study (PATHWAY) of palbociclib plus tamoxifen in patients with HR-positive/HER2-negative advanced breast cancer.
Emi Noguchi, Takashi Yamanaka, Hirofumi Mukai, Naohito Yamamoto, Chi-Feng Chung, Yoon Sim Yap

NPJ Breast Cancer· August 2024

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Outcomes in Nonmetastatic Hormone Receptor-Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study.
Ryan Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Seri Park, Jabed Iqbal, Yoon-Sim Yap

J Natl Compr Canc Netw· May 2024

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Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2- Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7.
Aleix Prat, Nadia Solovieff, Fabrice André, Joyce O'Shaughnessy, David A Cameron, Yoon-Sim Yap

Clin Cancer Res· February 2024

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Classification of HER2-negative breast cancers by copy number alteration status reveals molecular differences associated with chromosome 17 gene aberrations.
Jui Wan Loh, Abner Herbert Lim, Jason Yongsheng Chan, Yoon-Sim Yap

Ther Adv Med Oncol· October 2023

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Emerging systemic therapy options beyond CDK4/6 inhibitors for hormone receptor-positive HER2-negative advanced breast cancer.
Jun Ma, Jack Junjie Chan, Ching Han Toh, Yoon-Sim Yap

NPJ Breast Cancer· September 2023

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Correction: Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer.
Ning-Yuan Lee, Melissa Hum, Sabna Zihara, Lanying Wang, Matthew K Myint, Yoon-Sim Yap

Hum Genomics· August 2023

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Potential value of ctDNA monitoring in metastatic HR + /HER2 - breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial.
Joanne Chiu, Fei Su, Mukta Joshi, Norikazu Masuda, Takashi Ishikawa, Yoon-Sim Yap

BMC Med· August 2023

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Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer.
Ning-Yuan Lee, Melissa Hum, Sabna Zihara, Lanying Wang, Matthew K Myint, Yoon-Sim Yap

Hum Genomics· July 2023

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Exploiting metabolic vulnerabilities in breast cancers with NF1 loss.
Yoon-Sim Yap, Jiancheng Hu

Cell Rep Med· April 2023

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Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
Chiea Chuen Khor, Stefan Winter, Natalia Sutiman, Thomas E Mürdter, Sylvia Chen, Yoon Sim Yap

Clin Pharmacol Ther· March 2023

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Marker-free characterization of full-length transcriptomes of single live circulating tumor cells.
Sarita Poonia, Anurag Goel, Smriti Chawla, Namrata Bhattacharya, Priyadarshini Rai, Yoon Sim Yap

Genome Res· January 2023

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Isolated Facial Nerve Palsy Due to Temporal Bone Metastasis.
Sangeetha Isaac, Mohammed Afraz Pasha, Yoon Sim Yap, Jason Chan

Cureus· July 2022

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Disparities in Access to Systemic Treatment for Breast Cancer in Thailand and Major Asian Territories.
Suthinee Ithimakin, Napa Parinyanitikul, Sung-Bae Kim, Yoon-Sim Yap, Janice Tsang

J Breast Cancer· June 2022

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Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.
Gabriel N Hortobagyi, Salomon M Stemmer, Howard A Burris, Yoon-Sim Yap, Gabe S Sonke

N Engl J Med· March 2022

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HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis.
Ryan Shea Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Abner Herbert Lim, Seri Park, Yoon-Sim Yap

BMC Med· March 2022

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Liquid biopsies for residual disease and recurrence.
Jonathan Chee Ming Wan, Tariq Imdadali Mughal, Pedram Razavi, Sarah-Jane Dawson, Esther Louise Moss, Yoon-Sim Yap

Med· December 2021

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An Overview of the Treatment Efficacy and Side Effect Profile of Pharmacological Therapies in Asian Patients with Breast Cancer.
Yen-Shen Lu, Winnie Yeo, Yoon-Sim Yap, Yeon Hee Park, Kenji Tamura

Target Oncol· November 2021

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Analysis of the pan-Asian subgroup of patients in the NALA Trial: a randomized phase III NALA Trial comparing neratinib+capecitabine (N+C) vs lapatinib+capecitabine (L+C) in patients with HER2+metastatic breast cancer (mBC) previously treated with two or more HER2-directed regimens.
Ming Shen Dai, Yin Hsun Feng, Shang Wen Chen, Norikazu Masuda, Thomas Yau, Yoon Sim Yap

Breast Cancer Res Treat· October 2021

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Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer.
Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Yoon Sim Yap

Sci Adv· October 2021

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