Publications by authors named "Jianshuang Wang"

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E
Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib.
Qinying Yu, Li Ma, Leah M Norona, Peter S Dragovich, Jianshuang Wang, Shuai Wang, Xinpeng Wang

J Med Chem· August 2025

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Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.
Vikram Malhi, Priya Agarwal, Mary R Gates, Lichuan Liu, Jianshuang Wang

Cancer Res Commun· December 2023

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E
Exploring the potential of dried plasma collection cards for liquid chromatography coupled with tandem mass spectrometry quantitation of giredestrant in human plasma.
Yang Tang, Liuxi Chen, Xiaorong Liang, Brian Dean, Jianshuang Wang

Biomed Chromatogr· March 2023

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Volumetric absorptive microsampling-LC-MS/MS assays for quantitation of giredestrant in dried human whole blood.
Ryan Johnson, Imran Rehmani, Mark Leahy, Abigail Walker, Xiaorong Liang, Jianshuang Wang

Bioanalysis· November 2022

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Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function.
Rucha Sane, Vikram Malhi, Dhruvitkumar S Sutaria, Eunpi Cho, Patrick Twomey, Jianshuang Wang

J Clin Pharmacol· February 2022

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A
A phase 1, randomized study to evaluate safety, tolerability, and pharmacokinetics of GDC-3280, a potential novel anti-fibrotic small molecule, in healthy subjects.
Dorothy Cheung, Alice Fong, Han Ting Ding, Christopher R Cabanski, Jianshuang Wang

Pulm Pharmacol Ther· August 2021

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A
A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Shuai Wang, Buyun Chen, Peter Dragovich, Thomas Pillow, Leanna Staben, Jianshuang Wang

Drug Metab Dispos· May 2019

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D
Determination of a novel antifibrotic small molecule GDC-3280 in human plasma and urine by liquid chromatography tandem mass spectrometry to support its first-in-human clinical trial.
Jianshuang Wang, Michael Van Parys, Lin Pan, Yuan Chen, Dorothy Cheung

Biomed Chromatogr· April 2019

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Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery.
Xiaolin Zhang, Xiao Ding, Jianshuang Wang, Brian Dean

J Pharm Biomed Anal· February 2019

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Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Jialin Mao, Peter Fan, Susan Wong, Jianshuang Wang, Moulay Hicham Alaoui Ismaili

Pharm Res· November 2017

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A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers.
Lin Pan, Paula Belloni, Han Ting Ding, Jianshuang Wang, Christopher M Rubino

Adv Ther· September 2017

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Replication studies of carboxymethylated DNA lesions in human cells.
Jun Wu, Pengcheng Wang, Lin Li, Nicole L Williams, Debin Ji, Jianshuang Wang, Yinsheng Wang

Nucleic Acids Res· July 2017

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Development of a multi-matrix LC-MS/MS method for urea quantitation and its application in human respiratory disease studies.
Jianshuang Wang, Yang Gao, Drew W Dorshorst, Fang Cai, Meire Bremer

J Pharm Biomed Anal· January 2017

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Q
Quantification of Azaserine-Induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
Yang Yu, Jianshuang Wang, Pengcheng Wang, Yinsheng Wang

Anal Chem· August 2016

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Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions.
Changjun You, Pengcheng Wang, Stephanie L Nay, Jianshuang Wang, Xiaoxia Dai, Yinsheng Wang

ACS Chem Biol· May 2016

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Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA.
Changjun You, Jianshuang Wang, Xiaoxia Dai, Yinsheng Wang

Nucleic Acids Res· January 2015

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Translesion synthesis of 8,5'-cyclopurine-2'-deoxynucleosides by DNA polymerases η, ι, and ζ.
Changjun You, Ashley L Swanson, Xiaoxia Dai, Bifeng Yuan, Jianshuang Wang, Yinsheng Wang

J Biol Chem· October 2013

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I
In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine.
Nisana Andersen, Jianshuang Wang, Pengcheng Wang, Yong Jiang, Yinsheng Wang

Chem Res Toxicol· November 2012

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A
A quantitative assay for assessing the effects of DNA lesions on transcription.
Changjun You, Xiaoxia Dai, Bifeng Yuan, Jin Wang, Jianshuang Wang, Yinsheng Wang

Nat Chem Biol· October 2012

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Accurate and efficient bypass of 8,5'-cyclopurine-2'-deoxynucleosides by human and yeast DNA polymerase η.
Ashley L Swanson, Jianshuang Wang, Yinsheng Wang

Chem Res Toxicol· August 2012

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In vitro replication studies of carboxymethylated DNA lesions with Saccharomyces cerevisiae polymerase η.
Ashley L Swanson, Jianshuang Wang, Yinsheng Wang

Biochemistry· September 2011

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H
High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.
Bifeng Yuan, Jianshuang Wang, Huachuan Cao, Ruobai Sun, Yinsheng Wang

Nucleic Acids Res· August 2011

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Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N6-carboxymethyl-2'-deoxyadenosine or N4-carboxymethyl-2'-deoxycytidine.
Jianshuang Wang, Yinsheng Wang

Nucleic Acids Res· October 2010

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Chemical synthesis of oligodeoxyribonucleotides containing N3- and O4-carboxymethylthymidine and their formation in DNA.
Jianshuang Wang, Yinsheng Wang

Nucleic Acids Res· February 2009

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Thermodynamics and kinetics of the hydride-transfer cycles for 1-aryl-1,4-dihydronicotinamide and its 1,2-dihydroisomer.
Xiao-Qing Zhu, Lei Cao, Yang Liu, Yuan Yang, Jin-Yong Lu, Jian-Shuang Wang

Chemistry· August 2003

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