Publications by authors named "Jim Iley"

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New insights on repellent recognition by Anopheles gambiae odorant-binding protein 1.
George Tzotzos, Jim N Iley, Elaine A Moore

PLoS One· July 2018

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N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases.
Ana Bela Santana, Susana D Lucas, Lídia M Gonçalves, Henrique F Correia, Teresa A F Cardote, Jim Iley

Bioorg Med Chem Lett· June 2012

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A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation.
Graça Mata, Virgílio E do Rosário, Jim Iley, Luís Constantino, Rui Moreira

Bioorg Med Chem· January 2012

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Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase.
Jalmira Mulchande, Sandra I Simões, Maria M Gaspar, Carla V Eleutério, Rudi Oliveira, Jim Iley

J Enzyme Inhib Med Chem· April 2011

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4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Jalmira Mulchande, Rudi Oliveira, Marta Carrasco, Luís Gouveia, Rita C Guedes, Jim Iley

J Med Chem· January 2010

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Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.
Maria M M Santos, Natália Faria, Jim Iley, Simon J Coles, Michael B Hursthouse

Bioorg Med Chem Lett· January 2010

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Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.
M Jesus Perry, Eduarda Mendes, Ana Luísa Simplício, Ana Coelho, Ricardo V Soares, Jim Iley

Eur J Med Chem· August 2009

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The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development.
Patricia A Ragazzon, Tracey Bradshaw, Charlie Matthews, Jim Iley, Sotiris Missailidis

Anticancer Res· June 2009

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Structure-activity studies of the binding of the flavonoid scaffold to DNA.
Patricia A Ragazzon, Jim Iley, Sotiris Missailidis

Anticancer Res· June 2009

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Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: synthesis and stability of N-acylamino acid derivatives of triazenes.
Maria de Jesus Perry, Emília Carvalho, Eduarda Rosa, Jim Iley

Eur J Med Chem· March 2009

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Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design.
Tiago Rodrigues, Rui Moreira, Rita C Guedes, Jim Iley, Francisca Lopes

Arch Pharm (Weinheim)· June 2008

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Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor.
Tânia F Oliveira, Jalmira Mulchande, Rui Moreira, Jim Iley, Margarida Archer

Protein Pept Lett· April 2008

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Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.
Jalmira Mulchande, Rita C Guedes, Wing-Yin Tsang, Michael I Page, Rui Moreira, Jim Iley

J Med Chem· March 2008

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The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.
Cláudia Valente, Rui Moreira, Rita C Guedes, Jim Iley, Mohammed Jaffar

Bioorg Med Chem· August 2007

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The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion.
Jalmira Mulchande, Luisa Martins, Rui Moreira, Margarida Archer, Tania F Oliveira, Jim Iley

Org Biomol Chem· August 2007

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Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.
Lina Ribeiro, Nuno Silva, Jim Iley, Jarkko Rautio, Tomi Järvinen

Arch Pharm (Weinheim)· January 2007

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Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.
Cláudia Valente, Rita C Guedes, Rui Moreira, Jim Iley, Jiri Gut

Bioorg Med Chem Lett· August 2006

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The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases.
Jim Iley, Rui Moreira, Luísa Martins, Rita C Guedes, Cláudio M Soares

Bioorg Med Chem Lett· May 2006

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Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
Rui Moreira, Ana Bela Santana, Jim Iley, João Neres, Kenneth T Douglas

J Med Chem· July 2005

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Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials.
Maria João Araújo, Joana Bom, Rita Capela, Catarina Casimiro, Paula Chambel, Jim Iley

J Med Chem· February 2005

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Oxidation of tertiary benzamides by 5,10,15,20-tetraphenylporphyrinatoironIII chloride-tert-butylhydroperoxide.
Luis Constantino, Jim Iley

Org Biomol Chem· July 2004

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Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one.
Emília Valente, José R B Gomes, Rui Moreira, Jim Iley

J Org Chem· May 2004

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Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.
Eduarda Mendes, Tânia Furtado, João Neres, Jim Iley, Tomi Jarvinen

Bioorg Med Chem· March 2002

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