Publications by authors named "Kenneth T Douglas"

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1
1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities.
João Lavrado, Alexandra Paulo, Elena Bichenkova, Kenneth T Douglas, Rui Moreira

Magn Reson Chem· March 2012

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Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.
João Lavrado, Ghislain G Cabal, Miguel Prudêncio, Maria M Mota, Jiri Gut, Kenneth T Douglas

J Med Chem· February 2011

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D
DNA-mounted self-assembly: new approaches for genomic analysis and SNP detection.
Elena V Bichenkova, Zhaolei Lang, Xuan Yu, Candelaria Rogert, Kenneth T Douglas

Biochim Biophys Acta· January 2011

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B
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Matthew L H Chu, Zhaolei Lang, Leonard M G Chavas, João Neres, Olga S Fedorova, Kenneth T Douglas

Biochemistry· March 2010

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Molecular dynamics study of chemically engineered green fluorescent protein mutants: comparison of intramolecular fluorescence resonance energy transfer rate.
Felicity L Mitchell, Filipp Frank, Gabriel E Marks, Miho Suzuki, Kenneth T Douglas

Proteins· April 2009

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D
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.
João Neres, Mark L Brewer, Laura Ratier, Horacio Botti, Alejandro Buschiazzo, Kenneth T Douglas

Bioorg Med Chem Lett· February 2009

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C
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
Matthew L H Chu, Leonard M G Chavas, Kenneth T Douglas, Patrick A Eyers, Lydia Tabernero

J Biol Chem· August 2008

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SNP detection for cytochrome P450 alleles by target-assembled tandem oligonucleotide systems based on exciplexes.
Lindsey Walsh, Abdul Gbaj, Laura L Etchells, Kenneth T Douglas, Elena V Bichenkova

J Biomol Struct Dyn· June 2008

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Q
Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination.
Miho Suzuki, Yuzuru Husimi, Hirokazu Komatsu, Koji Suzuki, Kenneth T Douglas

J Am Chem Soc· April 2008

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Molecular probes: insights into design and analysis from computational and physical chemistry.
Felicity L Mitchell, Gabriel E Marks, Elena V Bichenkova, Kenneth T Douglas, Richard A Bryce

Biochem Soc Trans· February 2008

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T
Target-assembled exciplexes based on Scorpion oligonucleotides.
Abdul Gbaj, Lindsey Walsh, Maria Candelaria Rogert, Alireza Sardarian, Elena V Bichenkova, Kenneth T Douglas

Biosci Rep· February 2008

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Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.
João Neres, Richard A Bryce, Kenneth T Douglas

Drug Discov Today· February 2008

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Target-assembled ExciProbes: application to DNA detection at the level of PCR product and plasmid DNA.
Lindsey Walsh, Abdul Gbaj, Hannah E Savage, M Candelaria Rogert Bacigalupo, Elena V Bichenkova, Kenneth T Douglas

J Biomol Struct Dyn· December 2007

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The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.
Cláudia Valente, Rui Moreira, Rita C Guedes, Jim Iley, Mohammed Jaffar, Kenneth T Douglas

Bioorg Med Chem· August 2007

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D
Detection of nucleic acids in situ: novel oligonucleotide analogues for target-assembled DNA-mounted exciplexes.
Elena V Bichenkova, Abdul Gbaj, Lindsey Walsh, Hannah E Savage, Candelaria Rogert, Kenneth T Douglas

Org Biomol Chem· April 2007

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D
Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.
Virginia A McNally, Mehdi Rajabi, Abdul Gbaj, Ian J Stratford, Philip N Edwards, Kenneth T Douglas

J Pharm Pharmacol· April 2007

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B
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.
João Neres, Pascal Bonnet, Philip N Edwards, Pravin L Kotian, Alejandro Buschiazzo, Kenneth T Douglas

Bioorg Med Chem· March 2007

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K
Kinetic conformational analysis of human 8-oxoguanine-DNA glycosylase.
Nikita A Kuznetsov, Vladimir V Koval, Georgy A Nevinsky, Kenneth T Douglas, Dmitry O Zharkov

J Biol Chem· January 2007

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Pre-steady-state kinetic study of substrate specificity of Escherichia coli formamidopyrimidine--DNA glycosylase.
Nikita A Kuznetsov, Vladimir V Koval, Dmitry O Zharkov, Yuri N Vorobjev, Georgy A Nevinsky, Kenneth T Douglas

Biochemistry· January 2007

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C
Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi.
João Neres, Alejandro Buschiazzo, Pedro M Alzari, Lindsey Walsh, Kenneth T Douglas

Anal Biochem· October 2006

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B
Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein.
Wei Zhang, Clifford J Steer, Kenneth T Douglas, Cecilia M P Rodrigues

Biosci Rep· June 2006

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T
Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants.
Abdul Gbaj, Philip N Edwards, Philip Reigan, Sally Freeman, Mohammed Jaffar, Kenneth T Douglas

J Enzyme Inhib Med Chem· February 2006

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E
Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors.
Elena V Bichenkova, Ali R Sardarian, Amanda N Wilton, Pascal Bonnet, Richard A Bryce, Kenneth T Douglas

Org Biomol Chem· January 2006

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A
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.
Seheli Parveen, Mohammed O F Khan, Susan E Austin, Simon L Croft, Vanessa Yardley, Kenneth T Douglas

J Med Chem· December 2005

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D
Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
Rui Moreira, Ana Bela Santana, Jim Iley, João Neres, Kenneth T Douglas

J Med Chem· July 2005

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