Publications by authors named "Sally Freeman"

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Understanding a Potential Role for the NLRP3 Inflammasome in Placenta-Mediated Pregnancy Complications.
Chloe G Moss, Mark R Dilworth, Lynda K Harris, Sally Freeman, Alexander E P Heazell

Am J Reprod Immunol· April 2025

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Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome.
Sherihan El-Sayed, Emily McMahon, Sondos Musleh, Sally Freeman, David Brough

Bioorg Chem· December 2024

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Discovery of Potent Benzothiazole Inhibitors of Oxidoreductase NQO2, a Target for Inflammation and Cancer.
Asma A Belgath, Aya M Emam, Joshua Taujanskas, Richard A Bryce, Sally Freeman

Int J Mol Sci· November 2024

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Brazilin is a natural product inhibitor of the NLRP3 inflammasome.
Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Sally Freeman

iScience· February 2024

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Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium.
Paula I Seoane, James A Beswick, Andrew G Leach, Tessa Swanton, Lucy V Morris, Sally Freeman

Cell Death Discov· December 2023

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Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria.
Rachael N Magwaza, Muna Abubaker, Buthaina Hussain, Michael Haley, Kevin Couper, Sally Freeman

Molecules· September 2023

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Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels.
Kathleen Elverson, Sally Freeman, Forbes Manson, Jim Warwicker

Molecules· July 2023

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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.
Jack P Green, Lina Y El-Sharkawy, Stefan Roth, Jie Zhu, Jiayu Cao, Sally Freeman

iScience· May 2023

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Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel.
Kathleen Elverson, Jim Warwicker, Sally Freeman, Forbes Manson

Molecules· April 2023

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Targeting firing rate neuronal homeostasis can prevent seizures.
Fred Mulroe, Wei-Hsiang Lin, Connie Mackenzie-Gray Scott, Najat Aourz, Yuen Ngan Fan, Sally Freeman

Dis Model Mech· October 2022

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Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation.
Sherihan El-Sayed, Sally Freeman, Richard A Bryce

Protein Sci· October 2022

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A Selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome.
Sherihan El-Sayed, Sally Freeman, Richard A Bryce

Molecules· September 2022

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A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects.
Victoria M Robinson, Izzeddin Alsalahat, Sally Freeman, Charles Antzelevitch, Héctor Barajas-Martinez

Br J Pharmacol· June 2022

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SAR of Novel 3-Arylisoquinolinones: -Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules.
Mai A Elhemely, Asma A Belgath, Sherihan El-Sayed, Kepa K Burusco, Manikandan Kadirvel, Sally Freeman

J Med Chem· March 2022

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Selected Derivatives of Erythromycin B- and Anti-Malarial Studies.
Pranab K Bhadra, Rachael N Magwaza, Niroshini Nirmalan, Sally Freeman, Jill Barber

Materials (Basel)· November 2021

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Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease.
Izzeddin Alsalahat, Zubida M Al-Majdoub, Mutasem O Taha, Jill Barber, Harmesh Aojula, Sally Freeman

Biochem Biophys Rep· July 2021

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LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.
Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Sally Freeman

Elife· November 2020

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Inhibiting the NLRP3 Inflammasome.
Lina Y El-Sharkawy, David Brough, Sally Freeman

Molecules· November 2020

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Resveratrol-mediated cleavage of amyloid β peptide: potential relevance to Alzheimer's disease.
Sarmad Al-Edresi, Izzeddin Alsalahat, Sally Freeman, Harmesh Aojula, Jeffrey Penny

Neurobiol Aging· October 2020

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Selective inhibition of the K efflux sensitive NLRP3 pathway by Cl channel modulation.
Tessa Swanton, James A Beswick, Halah Hammadi, Lucy Morris, Daniel Williams, Sally Freeman

Chem Sci· October 2020

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Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.
Jingshu Liu, Rachel L Taylor, Richard A Baines, Lisa Swanton, Sally Freeman

Invest Ophthalmol Vis Sci· May 2020

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Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Buthaina Hussein, Balqis Ikhmais, Manikandan Kadirvel, Rachael N Magwaza, Gavin Halbert, Sally Freeman

Eur J Med Chem· November 2019

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Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?
Tessa Swanton, James Cook, James A Beswick, Sally Freeman, Catherine B Lawrence

SLAS Discov· December 2018

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Radiosynthesis and reactivity of -[C]methyl carbamoylimidazole.
Manikandan Kadirvel, Déborah Cardoso, Sally Freeman, Gavin Brown

J Radioanal Nucl Chem· June 2018

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Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
Elena Redondo-Castro, Dorte Faust, Simon Fox, Alex G Baldwin, Simon Osborne, Sally Freeman

Sci Rep· April 2018

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