Publications by authors named "Jim Pace"

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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
Khushbu Shah, Sherry Queener, Vivian Cody, Jim Pace, Aleem Gangjee

Bioorg Med Chem Lett· August 2019

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Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
Khushbu Shah, Xin Lin, Sherry F Queener, Vivian Cody, Jim Pace

Bioorg Med Chem· May 2018

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Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
Vivian Cody, Jim Pace, Ojas A Namjoshi, Aleem Gangjee

Acta Crystallogr F Struct Biol Commun· June 2015

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Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.
Vivian Cody, Jim Pace, Sherry F Queener, Ona O Adair, Aleem Gangjee

Antimicrob Agents Chemother· June 2013

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Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding.
Vivian Cody, Jim Pace, Hesham F Nawar, Natalie King-Lyons, Shuang Liang

Acta Crystallogr D Biol Crystallogr· December 2012

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Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine.
Vivian Cody, Jim Pace, Elizabeth Stewart

Acta Crystallogr Sect F Struct Biol Cryst Commun· April 2012

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Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
Vivian Cody, Jim Pace, Jennifer Piraino, Sherry F Queener

J Struct Biol· October 2011

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Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode.
Vivian Cody, Jim Pace, Jessica Nowak

Acta Crystallogr D Biol Crystallogr· October 2011

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Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives.
Vivian Cody, Jim Pace

Acta Crystallogr D Biol Crystallogr· January 2011

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Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
Vivian Cody, Jennifer Piraino, Jim Pace, Wei Li, Aleem Gangjee

Acta Crystallogr D Biol Crystallogr· December 2010

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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Aleem Gangjee, Wei Li, Lu Lin, Yibin Zeng, Michael Ihnat, Jim Pace

Bioorg Med Chem· October 2009

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The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex.
Vivian Cody, Jim Pace, Lu Lin, Aleem Gangjee

Acta Crystallogr Sect F Struct Biol Cryst Commun· August 2009

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Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Aleem Gangjee, Wei Li, Roy L Kisliuk, Vivian Cody, Jim Pace

J Med Chem· August 2009

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Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
Vivian Cody, Jim Pace, Jennifer Makin, Jennifer Piraino, Sherry F Queener

Biochemistry· March 2009

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Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.
Vivian Cody, Jim Pace, Andre Rosowsky

Acta Crystallogr D Biol Crystallogr· September 2008

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New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
Vivian Cody, Jim Pace, Kim Chisum, Andre Rosowsky

Proteins· December 2006

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