Publications by authors named "Sherry Queener"

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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
Khushbu Shah, Sherry Queener, Vivian Cody, Jim Pace, Aleem Gangjee

Bioorg Med Chem Lett· August 2019

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Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
Khushbu Shah, Xin Lin, Sherry F Queener, Vivian Cody, Jim Pace

Bioorg Med Chem· May 2018

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Discovery of potent and selective inhibitors of thymidylate synthase for opportunistic infections.
Nilesh Zaware, Hitesh Sharma, Jie Yang, Ravi Kumar Vyas Devambatla, Sherry F Queener

ACS Med Chem Lett· October 2013

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Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.
Vivian Cody, Jim Pace, Sherry F Queener, Ona O Adair, Aleem Gangjee

Antimicrob Agents Chemother· June 2013

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Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Aleem Gangjee, Ojas A Namjoshi, Sudhir Raghavan, Sherry F Queener, Roy L Kisliuk

J Med Chem· June 2013

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Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Christian Konrad, Sherry F Queener, Ronald C Wek, William J Sullivan

Antimicrob Agents Chemother· April 2013

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Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
Vivian Cody, Jim Pace, Jennifer Piraino, Sherry F Queener

J Struct Biol· October 2011

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Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii.
Bradley R Joyce, Sherry F Queener, Ronald C Wek, William J Sullivan

Proc Natl Acad Sci U S A· October 2010

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Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Seema Bag, Nilesh R Tawari, Sherry F Queener, Mariam S Degani

J Enzyme Inhib Med Chem· June 2010

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Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens.
Seema Bag, Nilesh R Tawari, Mariam S Degani, Sherry F Queener

Bioorg Med Chem· May 2010

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CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.
Aleem Gangjee, Xin Lin, Lisa R Biondo, Sherry F Queener

Bioorg Med Chem· February 2010

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Diversifying Biomedical Training: A Synergistic Intervention.
Gina Sanchez Gibau, Julie Foertsch, Janice Blum, Randy Brutkiewicz, Sherry Queener

J Women Minor Sci Eng· January 2010

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2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Aleem Gangjee, Hiteshkumar D Jain, Jaclyn Phan, Xin Guo, Sherry F Queener

Bioorg Med Chem· January 2010

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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Aleem Gangjee, Wei Li, Lu Lin, Yibin Zeng, Michael Ihnat, Sherry F Queener

Bioorg Med Chem· October 2009

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Selective antifolates for chemically labeling proteins in mammalian cells.
Laura E Pedró Rosa, D Rajasekhar Reddy, Sherry F Queener, Lawrence W Miller

Chembiochem· June 2009

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Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
Vivian Cody, Jim Pace, Jennifer Makin, Jennifer Piraino, Sherry F Queener

Biochemistry· March 2009

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Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA.
Vivian Cody, Qilong Mao, Sherry F Queener

Protein Expr Purif· November 2008

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N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Aleem Gangjee, Ona O Adair, Michelle Pagley, Sherry F Queener

J Med Chem· October 2008

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The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Aleem Gangjee, Hiteshkumar D Jain, Sherry F Queener, Roy L Kisliuk

J Med Chem· August 2008

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Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.
Ernest J Mui, Guy A Schiehser, Wilbur K Milhous, Honghue Hsu, Craig W Roberts, Sherry F Queener

PLoS Negl Trop Dis· March 2008

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Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
Robert C Reynolds, Shiela R Campbell, Ralph G Fairchild, Roy L Kisliuk, Peggy L Micca, Sherry F Queener

J Med Chem· July 2007

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Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Aleem Gangjee, Yibin Zeng, Tina Talreja, John J McGuire, Roy L Kisliuk, Sherry F Queener

J Med Chem· June 2007

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Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii.
Aaron T Smith, Meredith R Livingston, Antonello Mai, Patrizia Filetici, Sherry F Queener

Antimicrob Agents Chemother· March 2007

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Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.
Aleem Gangjee, Jie Yang, Sherry F Queener

Bioorg Med Chem· December 2006

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Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
David C M Chan, Hongning Fu, Ronald A Forsch, Sherry F Queener, Andre Rosowsky

J Med Chem· June 2005

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