Publications by authors named "Jinxue He"

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Design, synthesis and biological evaluation of novel PARP inhibitors against acquired drug-resistance.
Yuting Sun, Minghao Cao, Xiaofei Zhang, Xiajuan Huan, Qian He, Jinxue He

Eur J Med Chem· December 2025

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Combination of Cbl-b inhibitor NX-1607 and CDK4/6 inhibitor abemaciclib enhances anti-tumor immunity through PLCγ1/ERK-mediated T cell activation.
Shan Lu, Wen-Ting Zhu, Shan-Shan Song, Xu-Bin Bao, Ting Yu, Jin-Xue He

Cell Signal· November 2025

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VOPP1, a determinant of the sensitivity of non-small cell lung cancer cells to NAE inhibitors.
Ru-Jun Xu, Xu-Bin Bao, Ze-Hong Miao, Jin-Xue He

Eur J Pharmacol· September 2025

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Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation.
Wenting Zhu, Shan Lu, Li Jia, Benjin Liu, Shanshan Song, Jinxue He

J Immunother Cancer· May 2025

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USP7 V517F mutation as a mechanism of inhibitor resistance.
Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Jin-Xue He

Nat Commun· March 2025

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Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors.
Junjie Zhang, Benjin Liu, Ruyue Ren, Shanshan Song, Xubin Bao, Jinxue He

J Med Chem· February 2025

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Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy.
Zhen Zhuang, Yu-Ling Miao, Shan-Shan Song, Guang-Tong Leng, Xiao-Fei Zhang, Qian He, Jin-Xue He

Eur J Med Chem· November 2024

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Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7(8H)-one derivatives as potent USP1 inhibitors.
Hongrui Li, Ben-Jin Liu, Jiahao Xu, Shan-Shan Song, Ruixian Ba, Jin-Xue He

Eur J Med Chem· September 2024

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Identification of YCH2823 as a novel USP7 inhibitor for cancer therapy.
Yong-Jun Cheng, Zhen Zhuang, Yu-Ling Miao, Shan-Shan Song, Xu-Bin Bao, Jin-Xue He

Biochem Pharmacol· April 2024

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Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities.
Pingyuan Wang, Wen-Ting Zhu, Yajing Wang, Shan-Shan Song, Yong Xi, Yan-Yan Shen, Yi Chen, Jin-Xue He

Eur J Med Chem· November 2023

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YCH1899, a Highly Effective Phthalazin-1(2)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors.
Yuting Sun, Hui Yang, Jiaqi Yuan, Limin Wang, Shanshan Song, Rongrong Chen, Qian He, Jinxue He

J Med Chem· September 2023

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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance.
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Hua-Dong Chen, Yan-Yan Shen, Yi Chen, Jin-Xue He

EMBO Mol Med· March 2023

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Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion.
Ne Guo, Meng-Zhu Li, Li-Min Wang, Hua-Dong Chen, Shan-Shan Song, Jin-Xue He

Cancer Biol Ther· December 2022

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Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone.
Muzaffar Kayumov, Li Jia, Azizbek Pardaev, Shan-Shan Song, Sharafitdin Mirzaakhmedov, Yong-Jun Cheng, Jin-Xue He

Eur J Med Chem· October 2022

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SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy.
Li-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, Shan-Shan Song, Xu-Bin Bao, Jin-Xue He

Neoplasia· October 2022

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Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers.
Meng-Zhu Li, Tao Meng, Shan-Shan Song, Xu-Bin Bao, Lan-Ping Ma, Jing-Kang Shen, Jin-Xue He

Invest New Drugs· October 2021

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Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold.
Chaodong Xiong, Lina Zhou, Jing Tan, Shanshan Song, Xubin Bao, Jin-Xue He

J Med Chem· May 2021

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Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Jin-Xue He

Cell Death Dis· February 2021

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Novel mutations in intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors.
Hua-Dong Chen, Ne Guo, Shan-Shan Song, Chuan-Huizi Chen, Ze-Hong Miao, Jin-Xue He

Am J Cancer Res· September 2020

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Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
Hua-Dong Chen, Chuan-Huizi Chen, Yu-Ting Wang, Ne Guo, Yu-Nan Tian, Jin-Xue He

Int J Cancer· August 2019

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Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.
Yu-Ting Wang, Bo Yuan, Hua-Dong Chen, Lin Xu, Yu-Nan Tian, Jin-Xue He

Cancer Sci· March 2018

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Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Jinxue He, Yanyan Shen, Yi Chen

Eur J Med Chem· September 2017

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Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors.
Zhong-Min Yang, Xue-Mei Liao, Yi Chen, Yan-Yan Shen, Xin-Ying Yang, Jin-Xue He

Acta Pharmacol Sin· July 2017

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Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.
Bo Yuan, Na Ye, Shan-Shan Song, Yu-Ting Wang, Zilan Song, Hua-Dong Chen, Chuan-Huizi Chen, Yan-Yan Shen, Yi Chen, Xiao-Yan Chen, Jin-Xue He

Cancer Lett· February 2017

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Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution.
Jin-Xue He, Meng Wang, Xia-Juan Huan, Chuan-Huizi Chen, Shan-Shan Song, Qian He, Yan-Yan Shen, Yi Chen, Xiao-Yan Chen

Oncotarget· January 2017

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