Publications by authors named "Jiri Strohalm"

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Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.
Ladislav Sivak, Vladimir Subr, Jakub Tomala, Blanka Rihova, Jiri Strohalm

Biomaterials· January 2017

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The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel.
Milada Šírová, Jiří Strohalm, Petr Chytil, Ondřej Lidický, Jakub Tomala

J Control Release· January 2017

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The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.
Barbora Tomalova, Milada Sirova, Pavel Rossmann, Robert Pola, Jiri Strohalm

J Control Release· February 2016

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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.
Pavel Šácha, Tomáš Knedlík, Jiří Schimer, Jan Tykvart, Jan Parolek, Jiří Strohalm

Angew Chem Int Ed Engl· February 2016

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Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates.
Ondřej Lidický, Olga Janoušková, Jiří Strohalm, Mahmudul Alam, Pavel Klener

Molecules· November 2015

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Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy.
Petra Votavova, Jakub Tomala, Vladimir Subr, Jiri Strohalm, Karel Ulbrich

J Biomed Nanotechnol· September 2015

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HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity.
Tomáš Etrych, Vladimír Subr, Jiří Strohalm, Milada Sírová, Blanka Ríhová

J Control Release· December 2012

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Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.
Jakub Tomala, Helena Chmelova, Jiri Strohalm, Karel Ulbrich, Milada Sirova

Int J Cancer· October 2011

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Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: comparison with free doxorubicin.
Vlastimil Masek, Eva Anzenbacherová, Tomás Etrych, Jirí Strohalm, Karel Ulbrich

Drug Metab Dispos· September 2011

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Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.
Tomáš Etrych, Lubomír Kovář, Jiří Strohalm, Petr Chytil, Blanka Ríhová

J Control Release· September 2011

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Poly[N-(2-hydroxypropyl)methacrylamide]-based tissue-embedding medium compatible with MALDI mass spectrometry imaging experiments.
Martin Strohalm, Jiří Strohalm, Filip Kaftan, Lukáš Krásný, Michael Volný

Anal Chem· July 2011

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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
Tomáš Etrych, Jiří Strohalm, Petr Chytil, Peter Černoch, Larisa Starovoytova

Eur J Pharm Sci· April 2011

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Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation.
Ondřej Hovorka, Vladimír Subr, David Větvička, Lubomír Kovář, Jiří Strohalm, Martin Strohalm

Eur J Pharm Biopharm· November 2010

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Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells.
Lubomir Kovar, Tomas Etrych, Martina Kabesova, Vladimir Subr, David Vetvicka, Jiri Strohalm

Tumour Biol· August 2010

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HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.
Tomás Etrych, Jirí Strohalm, Lubomír Kovár, Martina Kabesová, Blanka Ríhová

J Control Release· November 2009

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Overcoming immunoescape mechanisms of BCL1 leukemia and induction of CD8+ T-cell-mediated BCL1-specific resistance in mice cured by targeted polymer-bound doxorubicin.
Marek Kovar, Jakub Tomala, Helena Chmelova, Lubomir Kovar, Tomas Mrkvan, Jiri Strohalm

Cancer Res· December 2008

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The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line.
Lubomír Kovár, Jirí Strohalm, Petr Chytil, Tomás Mrkvan, Marek Kovár

Bioconjug Chem· August 2007

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Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice.
Milada Sirova, Jiri Strohalm, Vladimir Subr, Daniela Plocova, Pavel Rossmann

Cancer Immunol Immunother· January 2007

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HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition.
Ondrej Hovorka, Tomás Etrych, Vladimír Subr, Jirí Strohalm, Karel Ulbrich

J Drug Target· July 2006

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Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity.
Tomas Mrkvan, Milada Sirova, Tomas Etrych, Petr Chytil, Jiri Strohalm

J Control Release· December 2005

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Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs.
Markéta Jelínková, Jirí Strohalm, Tomás Etrych, Karel Ulbrich, Blanka Ríhová

Pharm Res· October 2003

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Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data.
Blanka Ríhová, Jirí Strohalm, Jana Prausová, Katerina Kubácková, Markéta Jelínková

J Control Release· August 2003

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Drug-HPMA-HuIg conjugates effective against human solid cancer.
Blanka Ríhová, Jirí Strohalm, Katerina Kubácková, Markéta Jelínková, Ladka Rozprimová

Adv Exp Med Biol· June 2003

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Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect.
Marek Kovár, Jirí Strohalm, Tomás Etrych, Karel Ulbrich, Blanka Ríhová

Bioconjug Chem· July 2002

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