Publications by authors named "Jiunn Lin"

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Demographic history and distinct selection signatures of two domestication genes in mungbean.
Ya-Ping Lin, Hung-Wei Chen, Pei-Min Yeh, Shashi S Anand, Jiunn Lin

Plant Physiol· September 2023

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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Kevin D Rynearson, Moorthi Ponnusamy, Olga Prikhodko, Yuhuan Xie, Can Zhang, Jiunn H Lin

J Exp Med· April 2021

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Pharmacological and Toxicological Properties of the Potent Oral -Secretase Modulator BPN-15606.
Steven L Wagner, Kevin D Rynearson, Steven K Duddy, Can Zhang, Phuong D Nguyen, Jiunn H Lin

J Pharmacol Exp Ther· July 2017

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An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes.
Jing-Jing Wang, Jian-Jun Guo, Jenny Zhan, Hai-Zhi Bu, Jiunn H Lin

J Pharm Anal· August 2014

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Identification of insulin resistance in subjects with normal glucose tolerance.
Jiunn Diann Lin, Jin Biou Chang, Chung Ze Wu, Dee Pei, Chang Hsun Hsieh, Yen Lin Chen

Ann Acad Med Singap· February 2014

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Pharmacokinetics of biotech drugs: peptides, proteins and monoclonal antibodies.
Jiunn H Lin

Curr Drug Metab· September 2009

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Association between white blood cell count and components of metabolic syndrome.
Chung-Ze Wu, Jiunn D Lin, Jer-Chuan Li, Shi-Wen Kuo, Chang-Hsun Hsieh, Hsiang-Lin Wan

Pediatr Int· February 2009

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Applications and limitations of genetically modified mouse models in drug discovery and development.
Jiunn H Lin

Curr Drug Metab· June 2008

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CSF as a surrogate for assessing CNS exposure: an industrial perspective.
Jiunn H Lin

Curr Drug Metab· January 2008

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Impaired glucose tolerance and impaired fasting glucose share similar underlying pathophysiologies.
Jiunn Diann Lin, Hsiang-Lin Wan, Jer-Chuan Li, Chung-Ze Wu, Shi-Wen Kuo

Tohoku J Exp Med· August 2007

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Transporter-mediated drug interactions: clinical implications and in vitro assessment.
Jiunn H Lin

Expert Opin Drug Metab Toxicol· February 2007

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Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy.
Jiunn H Lin

Curr Drug Metab· February 2007

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Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites.
Thomayant Prueksaritanont, Jiunn H Lin, Thomas A Baillie

Toxicol Appl Pharmacol· December 2006

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In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies.
Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Jiunn H Lin

Drug Metab Dispos· September 2006

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications.
Jiunn H Lin

Pharm Res· June 2006

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Tissue distribution and pharmacodynamics: a complicated relationship.
Jiunn H Lin

Curr Drug Metab· January 2006

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Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Zhijian Lu, Joann Bohn, Tom Rano, Carrie A Rutkowski, Amy L Simcoe, Jiunn H Lin

Bioorg Med Chem Lett· December 2005

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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Mark W Embrey, John S Wai, Timothy W Funk, Carl F Homnick, Debbie S Perlow, Jiunn H Lin, Linghang Zhuang

Bioorg Med Chem Lett· October 2005

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Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: effects of gemfibrozil.
Thomayant Prueksaritanont, Yue Qiu, Lillian Mu, Kimberly Michel, Janice Brunner, Jiunn H Lin

Pharm Res· July 2005

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Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?
Cuyue Tang, Jiunn H Lin, Anthony Y H Lu

Drug Metab Dispos· May 2005

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Hepatic uptake of the novel antifungal agent caspofungin.
Punam Sandhu, Wooin Lee, Xin Xu, Brenda F Leake, Masayo Yamazaki, Jiunn H Lin

Drug Metab Dispos· May 2005

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Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2.
Qin Mei, Karen Richards, Kristie Strong-Basalyga, Scott E Fauty, Anne Taylor, Jiunn H Lin

J Pharm Sci· October 2004

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Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin.
Jerome H Hochman, Nicole Pudvah, Julia Qiu, Masayo Yamazaki, Cuyue Tang, Jiunn H Lin

Pharm Res· September 2004

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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Daria J Hazuda, Neville J Anthony, Robert P Gomez, Samson M Jolly, John S Wai, Linghang Zhuang, Jiunn H Lin

Proc Natl Acad Sci U S A· August 2004

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How significant is the role of P-glycoprotein in drug absorption and brain uptake?
Jiunn H Lin

Drugs Today (Barc)· January 2004

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