Publications by authors named "Kevin D Rynearson"

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Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606.
Jose A Godoy-Lugo, Max A Thorwald, Mafalda Cacciottolo, Carla D'Agostino, Ararat Chakhoyan, Kevin D Rynearson

Alzheimers Dement· September 2024

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γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.
Xu-Qiao Chen, Ann Becker, Ricardo Albay, Phuong D Nguyen, Dmitry Karachentsev, Kevin D Rynearson

Ann Neurol· August 2024

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Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.
Xu-Qiao Chen, Mariko Sawa, Ann Becker, Dmitry Karachentsev, Xinxin Zuo, Kevin D Rynearson

Ann Neurol· August 2023

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Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease.
Andrew B Caldwell, Qing Liu, Can Zhang, Gary P Schroth, Douglas R Galasko, Kevin D Rynearson

Alzheimers Dement· November 2022

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The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease.
Olga Prikhodko, Kevin D Rynearson, Travis Sekhon, Mike M Mante, Phuong D Nguyen

J Alzheimers Dis· May 2021

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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Kevin D Rynearson, Moorthi Ponnusamy, Olga Prikhodko, Yuhuan Xie, Can Zhang

J Exp Med· April 2021

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Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.
Yulong Xu, Changning Wang, Hsiao-Ying Wey, Yingxia Liang, Zude Chen, Kevin D Rynearson

J Exp Med· December 2020

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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Kevin D Rynearson, Ronald N Buckle, R Jason Herr, Nicholas J Mayhew, Xinchao Chen

Bioorg Med Chem· November 2020

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γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.
Marilia Barros, William J Houlihan, Chelsea J Paresi, Matthew Brendel, Kevin D Rynearson

Langmuir· June 2020

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
Rik van der Kant, Vanessa F Langness, Cheryl M Herrera, Daniel A Williams, Lauren K Fong, Kevin D Rynearson

Cell Stem Cell· March 2019

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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.
Frank Raven, Joseph F Ward, Katarzyna M Zoltowska, Yu Wan, Enjana Bylykbashi, Kevin D Rynearson

EBioMedicine· October 2017

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Pharmacological and Toxicological Properties of the Potent Oral -Secretase Modulator BPN-15606.
Steven L Wagner, Kevin D Rynearson, Steven K Duddy, Can Zhang, Phuong D Nguyen

J Pharmacol Exp Ther· July 2017

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Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
Kevin D Rynearson, Ronald N Buckle, Keith D Barnes, R Jason Herr, Nicholas J Mayhew

Bioorg Med Chem Lett· August 2016

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2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.
Kevin D Rynearson, Brian Charrette, Christopher Gabriel, Jesus Moreno, Mark A Boerneke

Bioorg Med Chem Lett· August 2014

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Nanopore-based conformational analysis of a viral RNA drug target.
Carolyn Shasha, Robert Y Henley, Daniel H Stoloff, Kevin D Rynearson, Thomas Hermann

ACS Nano· June 2014

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Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.
Sergey M Dibrov, Jerod Parsons, Maia Carnevali, Shu Zhou, Kevin D Rynearson

J Med Chem· March 2014

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Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Steven L Wagner, Can Zhang, Soan Cheng, Phuong Nguyen, Xulun Zhang, Kevin D Rynearson

Biochemistry· February 2014

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Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.
Shou Zhou, Kevin D Rynearson, Kejia Ding, Nicholas D Brunn, Thomas Hermann

Bioorg Med Chem· October 2013

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1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.
Sanjay Dutta, Cody J Higginson, Bao T Ho, Kevin D Rynearson, Sergey M Dibrov

Org Lett· January 2010

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