Publications by authors named "Johan Flygare"

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Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions.
Kiyoka Saito, Mark van der Garde, Terumasa Umemoto, Natsumi Miharada, Julia Sjöberg, Johan Flygare

Nat Commun· September 2024

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Recombinant α-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a Lu-DOTATATE Mouse Radiation Model.
Abdul Ghani Alattar, Amanda Kristiansson, Helena Karlsson, Suvi Vallius, Jonas Ahlstedt, Johan Flygare

Biomolecules· June 2023

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Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway.
Katherine M Hannan, Priscilla Soo, Mei S Wong, Justine K Lee, Nadine Hein, Johan Flygare

Cell Rep· November 2022

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Small Molecules Pushing Erythroid/Megakaryocyte Cell Specification Boundaries.
Johan Flygare

Cell Reprogram· October 2022

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Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34 cord blood hematopoietic stem cells using a clinically applicable lentiviral vector.
Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M Smith, Johan Flygare

Haematologica· February 2022

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Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia.
Sara E Sjögren, Jun Chen, Alexander Mattebo, Abdul G Alattar, Helena Karlsson, Johan Flygare

Exp Hematol· January 2022

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The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond-Blackfan anemia by targeting Nemo-like kinase.
Mark C Wilkes, Kevin Jung, Britney E Lee, Mallika Saxena, Ryan S Sathianathen, Johan Flygare

J Biol Chem· September 2021

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Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Alexander Mattebo, Taha Sen, Maria Jassinskaja, Kristýna Pimková, Isabel Prieto González-Albo, Johan Flygare

Sci Rep· August 2021

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Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan anemia corrects the disease phenotype.
Maria Dahl, Sarah Warsi, Yang Liu, Shubhranshu Debnath, Matilda Billing, Johan Flygare

Exp Hematol· July 2021

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Human radical scavenger α-microglobulin protects against hemolysis in vitro and α-microglobulin knockout mice exhibit a macrocytic anemia phenotype.
Amanda Kristiansson, Jesper Bergwik, Abdul Ghani Alattar, Johan Flygare, Magnus Gram

Free Radic Biol Med· January 2021

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Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.
Mark C Wilkes, Kavitha Siva, Gianluca Varetti, Jacqueline Mercado, Ethan P Wentworth, Johan Flygare

Exp Hematol· November 2020

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Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output.
Sofie Singbrant, Alexander Mattebo, Mikael Sigvardsson, Tobias Strid, Johan Flygare

Haematologica· November 2020

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Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Alison M Taylor, Elizabeth R Macari, Iris T Chan, Megan C Blair, Sergei Doulatov, Johan Flygare

Sci Transl Med· October 2020

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The Role of α-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions.
Amanda Kristiansson, Magnus Gram, Johan Flygare, Stefan R Hansson, Bo Åkerström

Int J Mol Sci· September 2020

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Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing.
Mehdi Amirhosseini, Magnus Bernhardsson, Pernilla Lång, Göran Andersson, Johan Flygare

J Cell Physiol· September 2019

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A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia.
Kavitha Siva, Fredrik Ek, Jun Chen, Abdul Ghani Alattar, Kristmundur Sigmundsson, Johan Flygare

SLAS Discov· March 2019

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Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors.
Melissa Ilsley, Sandra Capellera-Garcia, Kishori Dhulipala, Alban Johansson, Johan Flygare

J Vis Exp· December 2018

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Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Shubhranshu Debnath, Pekka Jaako, Kavitha Siva, Michael Rothe, Jun Chen, Johan Flygare

Mol Ther· August 2017

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Direct lineage reprogramming: a useful addition to the blood cell research toolbox.
Sandra Capellera-Garcia, Johan Flygare

Expert Rev Hematol· February 2017

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Direct Conversion of Fibroblasts to Megakaryocyte Progenitors.
Julian Pulecio, Oriol Alejo-Valle, Sandra Capellera-Garcia, Marianna Vitaloni, Paula Rio, Johan Flygare

Cell Rep· October 2016

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Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion.
Sandra Capellera-Garcia, Julian Pulecio, Kishori Dhulipala, Kavitha Siva, Violeta Rayon-Estrada, Johan Flygare

Cell Rep· June 2016

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Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
Sara E Sjögren, Kavitha Siva, Shamit Soneji, Amee J George, Marcus Winkler, Johan Flygare

Br J Haematol· November 2015

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Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia.
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Ute Modlich, Michael Rothe, Johan Flygare

Haematologica· December 2014

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ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.
Lingbo Zhang, Lina Prak, Violeta Rayon-Estrada, Prathapan Thiru, Johan Flygare

Nature· July 2013

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Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells.
Song Chou, Johan Flygare, Harvey F Lodish

Exp Hematol· May 2013

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