Publications by authors named "Ute Modlich"

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Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene.
Julia Fekadu-Siebald, Nina V Fuchs, Stella Zahn, Marcel G E Rommel, Franziska Schenk, Ute Modlich

Stem Cell Res· December 2024

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Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements.
Federica Raimondi, Kah Mun Siow, Dominik Wrona, Carla Fuster-García, Oleksandr Pastukhov, Ute Modlich

Commun Biol· October 2024

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Targeted knock-in of cDNA into the locus leads to myeloid phenotypic correction of p47 -deficient chronic granulomatous disease.
Kah Mun Siow, Merve Güngör, Dominik Wrona, Federica Raimondi, Oleksandr Pastukhov, Ute Modlich

Mol Ther Nucleic Acids· September 2024

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Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia.
Tanja Hirch, Nadine Brander, Franziska Schenk, Simon J Pöllmann, Janine Reichenbach, Ute Modlich

Sci Rep· November 2023

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Lentiviral gene therapy reverts GPIX expression and phenotype in Bernard-Soulier syndrome type C.
Gonzalo Martinez-Navajas, Jorge Ceron-Hernandez, Iris Simon, Pablo Lupiañez, Sofia Diaz-McLynn, Ute Modlich

Mol Ther Nucleic Acids· September 2023

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Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output.
Marcel G E Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Ute Modlich

Cell Rep· October 2022

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Targeting transgenic proteins to alpha granules for platelet-directed gene therapy.
Vanessa M A Woods, Lisette J Latorre-Rey, Franziska Schenk, Marcel G E Rommel, Thomas Moritz, Ute Modlich

Mol Ther Nucleic Acids· March 2022

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Understanding the Role of LFA-1 in Leukocyte Adhesion Deficiency Type I (LAD I): Moving towards Inflammation?
Julia Fekadu, Ute Modlich, Peter Bader, Shahrzad Bakhtiar

Int J Mol Sci· March 2022

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Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning.
Adrian Schwarzer, Steven R Talbot, Anton Selich, Michael Morgan, Juliane W Schott, Ute Modlich

Mol Ther· December 2021

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Establishment of a novel stable human suspension packaging cell line producing ecotropic retroviral MLV(PVC-211) vectors efficiently transducing murine hematopoietic stem and progenitor cells.
Yasemin van Heuvel, Karen Berg, Tanja Hirch, Kristina Winn, Ute Modlich

J Virol Methods· November 2021

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Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors.
Katharina Cullmann, Magdalena Jahn, Markus Spindler, Franziska Schenk, Georgi Manukjan, Ute Modlich

Res Pract Thromb Haemost· January 2021

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Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in -Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia.
Ruth Duecker, Patrick C Baer, Aileen Buecker, Sabine Huenecke, Lisa-Marie Pfeffermann, Ute Modlich

Front Immunol· November 2020

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High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia.
Stephan Müller, Tobias Bexte, Veronika Gebel, Franziska Kalensee, Eva Stolzenberg, Ute Modlich

Front Immunol· November 2020

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Endothelial-platelet interactions in influenza-induced pneumonia: A potential therapeutic target.
Marcel G E Rommel, Christian Milde, Regina Eberle, Harald Schulze, Ute Modlich

Anat Histol Embryol· September 2020

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Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim.
Marcel G E Rommel, Keven Hoerster, Christian Milde, Franziska Schenk, Luise Roser, Ute Modlich

Exp Hematol· May 2020

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Zika virus infection studies with CD34 hematopoietic and megakaryocyte-erythroid progenitors, red blood cells and platelets.
Hanna Roth, Lucas Schneider, Regina Eberle, Jörn Lausen, Ute Modlich

Transfusion· March 2020

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Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice.
Saskia Kohlscheen, Franziska Schenk, Marcel G E Rommel, Katharina Cullmann, Ute Modlich

Blood· March 2019

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Sustained and regulated gene expression by Tet-inducible "all-in-one" retroviral vectors containing the HNRPA2B1-CBX3 UCOE.
Katharina Cullmann, Kaj E C Blokland, Attila Sebe, Franziska Schenk, Zoltán Ivics, Ute Modlich

Biomaterials· February 2019

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generation of human CD19-CAR T cells results in B-cell depletion and signs of cytokine release syndrome.
Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Ute Modlich

EMBO Mol Med· November 2018

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Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.
Christian Brendel, Michael Rothe, Giorgia Santilli, Sabine Charrier, Stefan Stein, Ute Modlich

Hum Gene Ther Clin Dev· June 2018

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Promises and Challenges in Hematopoietic Stem Cell Gene Therapy.
Saskia Kohlscheen, Halvard Bonig, Ute Modlich

Hum Gene Ther· October 2017

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Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.
Sara El Ashkar, Dominique Van Looveren, Franziska Schenk, Lenard S Vranckx, Jonas Demeulemeester, Ute Modlich

Mol Ther Nucleic Acids· June 2017

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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Ute Modlich

Nat Commun· June 2017

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CD30 Receptor-Targeted Lentiviral Vectors for Human Induced Pluripotent Stem Cell-Specific Gene Modification.
Thorsten Friedel, Sabine Jung-Klawitter, Attila Sebe, Franziska Schenk, Ute Modlich

Stem Cells Dev· May 2016

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The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation.
Tim Ripperger, Georgi Manukjan, Johann Meyer, Sabine Wolter, Axel Schambach, Ute Modlich

Biochim Biophys Acta· September 2015

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