Publications by authors named "Johannes Melms"

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Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis.
Solomiia Savchuk, Kaylee M Gentry, Wengang Wang, Elana Carleton, Carlos A O Biagi-Junior, Johannes C Melms

Nature· October 2025

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Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment.
Zachary H Walsh, Chris J Frangieh, Neeharika Kothapalli, Jay Levy, Clarissa K Heck, Johannes C Melms

Cell· September 2025

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Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases.
Somnath Tagore, Lindsay Caprio, Amit Dipak Amin, Kresimir Bestak, Karan Luthria, Johannes C Melms

Nat Med· April 2025

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Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.
Atsushi Sugimoto, Yoshinobu Saito, Guanxiong Wang, Qiuyan Sun, Chuan Yin, Johannes Melms

Nature· April 2025

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Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Shivem B Shah, Gergo Nikolenyi, Johannes C Melms

Nat Biotechnol· March 2025

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micronuclAI enables automated quantification of micronuclei for assessment of chromosomal instability.
Miguel A Ibarra-Arellano, Lindsay A Caprio, Aroj Hada, Niklas Stotzem, Luke L Cai, Johannes C Melms

Commun Biol· March 2025

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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C Melms, Sebastian Niezen

Genome Biol· March 2025

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Single-Cell Profiling of Sarcomas from Archival Tissue Reveals Programs Associated with Resistance to Immune Checkpoint Blockade.
Karan Luthria, Parin Shah, Blake Caldwell, Johannes C Melms, Sinan Abuzaid

Clin Cancer Res· October 2024

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micronuclAI: Automated quantification of micronuclei for assessment of chromosomal instability.
Miguel A Ibarra-Arellano, Lindsay A Caprio, Aroj Hada, Niklas Stotzem, Luke Cai, Johannes C Melms

bioRxiv· May 2024

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Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug

Nat Cancer· March 2024

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From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6.
Johannes C Melms, Patricia Ho, Meri Rogava, Benjamin Izar

Genes Immun· February 2024

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Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee

Nat Commun· January 2024

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Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
Nasser K Altorki, Zachary H Walsh, Johannes C Melms, Jeffery L Port, Benjamin E Lee

Nat Commun· December 2023

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Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells.
Zachary H Walsh, Parin Shah, Neeharika Kothapalli, Gergo Nikolenyi, Shivem B Shah, Johannes C Melms

bioRxiv· December 2023

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KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Johannes C Melms

J Immunother Cancer· September 2023

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Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy.
Everardo Hegewisch-Solloa, Janine E Melsen, Hiranmayi Ravichandran, André F Rendeiro, Aharon G Freud, Johannes C Melms

bioRxiv· September 2023

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.
Patricia Ho, Johannes C Melms, Meri Rogava, Chris J Frangieh, Joanna Poźniak

Cancer Cell· July 2023

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Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.
Yiping Wang, Joy Linyue Fan, Johannes C Melms, Amit Dipak Amin, Yohanna Georgis

Nat Genet· January 2023

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B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression.
David Hou, Brandyn Castro, Mark Dapash, Andrew Zolp, Joshua Katz, Johannes Melms

Res Sq· January 2023

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KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Aleksandar Obradovic, Johannes C Melms

bioRxiv· January 2023

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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C Melms, Sebastian Niezen

bioRxiv· October 2022

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Contribution of -labeled cells to alveolar regeneration is independent of tuft cells.
Huachao Huang, Yinshan Fang, Ming Jiang, Yihan Zhang, Jana Biermann, Johannes C Melms

Elife· September 2022

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Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio

Cell· July 2022

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Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
Amanda Garrido, Eunjeong Kim, Ana Teijeiro, Paula Sánchez Sánchez, Rosa Gallo, Johannes C Melms

J Hepatol· April 2022

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Author Correction: A molecular single-cell lung atlas of lethal COVID-19.
Johannes C Melms, Jana Biermann, Huachao Huang, Yiping Wang, Ajay Nair

Nature· October 2021

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