Publications by authors named "John Boylan"

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Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischemia reperfusion injury requires VEGFR2 signaling.
Don Walsh, Daria S Kostyunina, Aoife Blake, John Boylan, Paul McLoughlin

Am J Physiol Lung Cell Mol Physiol· March 2025

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CAPILLARY LEAK AND EDEMA AFTER RESUSCITATION: THE POTENTIAL CONTRIBUTION OF REDUCED ENDOTHELIAL SHEAR STRESS CAUSED BY HEMODILUTION.
Don Walsh, Ciara Cunning, Graham Lee, John Boylan, Paul McLoughlin

Shock· October 2023

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Early warning scores and critical care transfer - patient heterogeneity, low sensitivity, high mortality.
Claire C Nestor, Maria Donnelly, Siobhán Connors, Patricia Morrison, John Boylan

Ir J Med Sci· February 2022

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Correction to: Early warning scores and critical care transfer - patient heterogeneity, low sensitivity, high mortality.
Claire C Nestor, Maria Donnelly, Siobhán Connors, Patricia Morrison, John Boylan

Ir J Med Sci· February 2022

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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
Jan Elsner, Dan Cashion, Dale Robinson, Sogole Bahmanyar, Lida Tehrani, John F Boylan

J Med Chem· September 2021

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Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery: A Case Series.
Shrijit Nair, Siobhan McGuinness, Fouad Masood, John F Boylan, Niamh P Conlon

A A Pract· November 2019

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
Jennifer R Riggs, Jan Elsner, Dan Cashion, Dale Robinson, Lida Tehrani, John F Boylan

J Med Chem· May 2019

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G-S Checkpoint.
Dan Zhu, Shuichan Xu, Gordafaried Deyanat-Yazdi, Sophie X Peng, Leo A Barnes, John F Boylan

Mol Cancer Ther· August 2018

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The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial.
David Cosgrave, Marie Galligan, Era Soukhin, Victoria McMullan, Siobhan McGuinness, John Boylan

Trials· December 2017

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
Jennifer R Riggs, Mark Nagy, Jan Elsner, Paul Erdman, Dan Cashion, John F Boylan

J Med Chem· November 2017

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Prolonged Unexplained Hypoxemia as Initial Presentation of Cirrhosis: A Case Report.
Anand Puttappa, Kumaraswamy Sheshadri, Aurelie Fabre, Georgina Imberger, John Boylan

Am J Case Rep· January 2017

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Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis.
Noelle Murphy, Katherine U Gaynor, Simon C Rowan, Sinead M Walsh, Aurelie Fabre, John Boylan

Am J Pathol· March 2016

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What do we treat when we treat ARDS?
Takeshi Yoshida, John F Boylan, Brian P Kavanagh

Intensive Care Med· February 2016

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Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant: Problems with Power, Precision, and Type 1 Error Protection.
Georgina Imberger, Christian Gluud, John Boylan, Jørn Wetterslev

Anesth Analg· December 2015

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Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.
Carmela Dantas-Barbosa, Guillaume Bergthold, Estelle Daudigeos-Dubus, Heike Blockus, John F Boylan

Anticancer Drugs· March 2015

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Remote ischemic preconditioning does not affect the incidence of acute kidney injury after elective abdominal aortic aneurysm repair.
Noelle Murphy, Ajith Vijayan, Stephen Frohlich, Frank O'Farrell, Mary Barry, John Boylan

J Cardiothorac Vasc Anesth· October 2014

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Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability.
Wei He, Michael J Bennett, Leopoldo Luistro, Daisy Carvajal, Thomas Nevins, John F Boylan

Mol Ther· February 2014

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Acute respiratory distress syndrome: underrecognition by clinicians.
Stephen Fröhlich, Noelle Murphy, Aoife Doolan, Orla Ryan, John Boylan

J Crit Care· October 2013

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Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?
Stephen Fröhlich, John Boylan, Paul McLoughlin

Am J Respir Cell Mol Biol· March 2013

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.
Brenden Chen, Christine Tardell, Brian Higgins, Kathryn Packman, John F Boylan

PLoS One· January 2013

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Definition of acute respiratory distress syndrome.
Stephen Fröhlich, Noelle Murphy, John Boylan

JAMA· October 2012

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Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.
Anthony W Tolcher, Wells A Messersmith, Stanislaw M Mikulski, Kyriakos P Papadopoulos, Eunice L Kwak, John F Boylan

J Clin Oncol· July 2012

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The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.
Chanh Huynh, Laura Poliseno, Miguel F Segura, Ratna Medicherla, Adele Haimovic, John F Boylan

PLoS One· March 2012

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Identification of novel, potent and selective inhibitors of Polo-like kinase 1.
Shaoqing Chen, David Bartkovitz, Jianping Cai, Yi Chen, Zhi Chen, John F Boylan

Bioorg Med Chem Lett· January 2012

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Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.
Daina Z Ewton, Jing Hu, Maria Vilenchik, Xiaobing Deng, Kin-Chun Luk, John F Boylan

Mol Cancer Ther· November 2011

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