Publications by authors named "John Deadman"

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The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.
Neal Dalton, Christopher P Gordon, Timothy P Boyle, Nicholas Vandegraaf, John Deadman

Org Biomol Chem· July 2016

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Interrogating HIV integrase for compounds that bind--a SAMPL challenge.
Thomas S Peat, Olan Dolezal, Janet Newman, David Mobley, John J Deadman

J Comput Aided Mol Des· April 2014

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Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.
Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, John J Deadman

PLoS One· March 2013

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Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
Jerome Wielens, Stephen J Headey, David I Rhodes, Roger J Mulder, Olan Dolezal, John J Deadman

J Biomol Screen· February 2013

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Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.
John B Bremner, Paul A Keller, Stephen G Pyne, Mark J Robertson, K Sakthivel, John Deadman

Beilstein J Org Chem· October 2012

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Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
David I Rhodes, Thomas S Peat, Nick Vandegraaff, Dharshini Jeevarajah, Janet Newman, John J Deadman

Chembiochem· October 2011

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Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives.
Mark Robertson, John B Bremner, Jonathan Coates, John Deadman, Paul A Keller

Eur J Med Chem· September 2011

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Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid.
Daniel R Coghlan, John B Bremner, Paul A Keller, Stephen G Pyne, Dorothy M David, John Deadman

Bioorg Med Chem· June 2011

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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design.
David I Rhodes, Thomas S Peat, Nick Vandegraaff, Dharshini Jeevarajah, Giang Le, John J Deadman

Antivir Chem Chemother· March 2011

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Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1.
Jerome Wielens, Stephen J Headey, John J Deadman, David I Rhodes, Giang T Le

ChemMedChem· February 2011

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
Eric D Jones, Nick Vandegraaff, Giang Le, Neil Choi, William Issa, John J Deadman

Bioorg Med Chem Lett· October 2010

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
Giang Le, Nick Vandegraaff, David I Rhodes, Eric D Jones, Jonathan A V Coates, John J Deadman

Bioorg Med Chem Lett· October 2010

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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents.
Ben Li, Eric Dale Jones, Enkun Zhou, Li Chen, Dean Cameron Baylis, John Joseph Deadman

Bioorg Med Chem Lett· September 2010

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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses.
Giang Le, Nick Vandegraaff, David I Rhodes, Eric D Jones, Jonathan A V Coates, John J Deadman

Bioorg Med Chem Lett· September 2010

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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents.
Li Ben, Eric Dale Jones, Enkun Zhou, Chen Li, Dean Cameron Baylis, John Joseph Deadman

Bioorg Med Chem Lett· July 2010

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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, John Deadman

Bioorg Med Chem· July 2010

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Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Jerome Wielens, Stephen J Headey, Dharshini Jeevarajah, David I Rhodes, John Deadman

FEBS Lett· April 2010

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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, John Deadman

Bioorg Med Chem· April 2010

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Binaphthyl-based dicationic peptoids with therapeutic potential.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, John Deadman

Angew Chem Int Ed Engl· March 2010

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Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.
Jessica A Smith, Giang Le, Eric D Jones, John Deadman

Future Med Chem· February 2010

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Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.
Adel Garas, John B Bremner, Jonathan Coates, John Deadman, Paul A Keller

Bioorg Med Chem Lett· June 2009

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Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.
Timothy P Boyle, John B Bremner, Jonathan A Coates, John Deadman, Paul A Keller

Eur J Med Chem· March 2009

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A new methodology for the simulation of flexible protein-ligand interactions.
James Garner, John Deadman, David Rhodes, Renate Griffith, Paul A Keller

J Mol Graph Model· July 2007

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Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin.
Paulette A Greenidge, Sandrine A M Mérette, Richard Beck, Guy Dodson, Christopher A Goodwin, John J Deadman

J Med Chem· April 2003

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