Publications by authors named "Jonathan A Coates"

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The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.
Neal Dalton, Christopher P Gordon, Timothy P Boyle, Nicholas Vandegraaf, John Deadman, Jonathan A Coates

Org Biomol Chem· July 2016

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Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.
Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, Jonathan A V Coates

PLoS One· March 2013

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Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.
John B Bremner, Paul A Keller, Stephen G Pyne, Mark J Robertson, K Sakthivel, Jonathan A Coates

Beilstein J Org Chem· October 2012

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Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
David I Rhodes, Thomas S Peat, Nick Vandegraaff, Dharshini Jeevarajah, Janet Newman, Jonathan A V Coates

Chembiochem· October 2011

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Antiviral agents 3. Discovery of a novel small molecule non-nucleoside inhibitor of hepatitis B virus (HBV).
Ian T Crosby, David G Bourke, Eric D Jones, Tyrone P Jeynes, Susan Cox, Jonathan A V Coates

Bioorg Med Chem Lett· March 2011

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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design.
David I Rhodes, Thomas S Peat, Nick Vandegraaff, Dharshini Jeevarajah, Giang Le, Jonathan A V Coates

Antivir Chem Chemother· March 2011

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
Eric D Jones, Nick Vandegraaff, Giang Le, Neil Choi, William Issa, Jonathan A V Coates

Bioorg Med Chem Lett· October 2010

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
Giang Le, Nick Vandegraaff, David I Rhodes, Eric D Jones, Jonathan A V Coates

Bioorg Med Chem Lett· October 2010

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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents.
Ben Li, Eric Dale Jones, Enkun Zhou, Li Chen, Dean Cameron Baylis, Jonathan Alan Victor Coates

Bioorg Med Chem Lett· September 2010

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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses.
Giang Le, Nick Vandegraaff, David I Rhodes, Eric D Jones, Jonathan A V Coates

Bioorg Med Chem Lett· September 2010

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Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV.
Ian T Crosby, David G Bourke, Eric D Jones, Paula J de Bruyn, David Rhodes, Jonathan A V Coates

Bioorg Med Chem· September 2010

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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents.
Li Ben, Eric Dale Jones, Enkun Zhou, Chen Li, Dean Cameron Baylis, Jonathan Alan Victor Coates

Bioorg Med Chem Lett· July 2010

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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Jonathan A Coates

Bioorg Med Chem· July 2010

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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Jonathan A Coates

Bioorg Med Chem· April 2010

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Binaphthyl-based dicationic peptoids with therapeutic potential.
John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Jonathan A Coates

Angew Chem Int Ed Engl· March 2010

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Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.
Timothy P Boyle, John B Bremner, Jonathan A Coates, John Deadman, Paul A Keller

Eur J Med Chem· March 2009

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