Publications by authors named "John Engelhardt"

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LUNAR® LNP delivery of CFTR mRNA restores channel function and improves mucociliary clearance in human and ferret cystic fibrosis airways.
Xiaoming Liu, Javier Campos-Gomez, Meihui Luo, Jia Ma, Han-Chung Chen, John F Engelhardt

Mol Ther· December 2025

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Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.
Jacob Witten, Idris Raji, Rajith S Manan, Emily Beyer, Sandra Bartlett, John F Engelhardt

Nat Biotechnol· November 2025

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PRenatal mOdulator treatment to PrEvent CF complicaTions (PROTECT) workshop report.
Sylvia Szentpetery, Dara Riva, Yair J Blumenfeld, John F Engelhardt, Carmen Luna-Paredes

J Cyst Fibros· November 2025

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Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.
Shuang Wu, Ian Driver, Meihui Luo, Hikaru Miyazaki, Smitha Shambhu, John F Engelhardt

NPJ Regen Med· November 2025

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Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid.
Feng Yuan, Javahir Hajibabazade, Yaling Yi, Adriane E Thompson, Lianwu Fu, John F Engelhardt

Am J Respir Crit Care Med· October 2025

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Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation.
Feng Yuan, Xingshen Sun, Soo Yeun Park, Yinghua Tang, Zehua Feng, John F Engelhardt

Hum Gene Ther· August 2025

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Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells.
Soo Yeun Park, Zehua Feng, Soon H Choi, Xiujuan Zhang, Yinghua Tang, John F Engelhardt

Hum Gene Ther· August 2025

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Isolation and Culture of Ferret Airway Stem Cells.
Ziying Yan, John F Engelhardt, Feng Yuan

Bio Protoc· July 2025

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A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector.
Soo Yeun Park, Zehua Feng, Xiujuan Zhang, Yinghua Tang, Donovan Richart, John F Engelhardt

Viruses· June 2025

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Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.
Shuang Wu, Ian Drive, Meihui Luo, Hikaru Miyazaki, Smitha Shambhu, John F Engelhardt

bioRxiv· May 2025

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CFTR represses a PDX1 axis to govern pancreatic ductal cell fate.
Pavana G Rotti, Yaling Yi, Grace Gasser, Feng Yuan, Xingshen Sun, John F Engelhardt

iScience· December 2024

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Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRΔR gene delivery to adult ferret lungs.
Yinghua Tang, Mehrnoosh Ebadi, Junying Lei, Zehua Feng, Shahab Fakhari, John F Engelhardt

Mol Ther Methods Clin Dev· June 2024

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In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets.
Idil Apak Evans, Xingshen Sun, Bo Liang, Amber R Vegter, Lydia Guo, John F Engelhardt

JCI Insight· April 2024

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Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium.
Kang Ning, Xiujuan Zhang, Zehua Feng, Siyuan Hao, Cagla Aksu Kuz, John F Engelhardt

Mol Ther Methods Clin Dev· December 2023

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Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators.
Shan Wang, Suchan Niroula, Ashley Hoffman, Melika Khorrami, Melina Khorrami, John F Engelhardt

Am J Respir Crit Care Med· November 2023

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Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy.
Katherine B Hisert, Susan E Birket, John Paul Clancy, Damian G Downey, John F Engelhardt

Lancet Respir Med· October 2023

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Sonic Hedgehog Signaling Is Essential for Pulmonary Ionocyte Specification in Human and Ferret Airway Epithelia.
Qian Cai, Meihui Luo, Yinghua Tang, Miao Yu, Feng Yuan, John F Engelhardt

Am J Respir Cell Mol Biol· September 2023

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Transgenic ferret models define pulmonary ionocyte diversity and function.
Feng Yuan, Grace N Gasser, Evan Lemire, Daniel T Montoro, Karthik Jagadeesh, John F Engelhardt

Nature· September 2023

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Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment.
Kyra Laubach, Tolga Turan, Rebecca Mathew, Julie Wilsbacher, John Engelhardt

Cancer Drug Resist· September 2023

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Genome Editing in Ferret Airway Epithelia Mediated by CRISPR/Nucleases Delivered with Amphiphilic Shuttle Peptides.
Meihui Luo, Jia Ma, Xue Cheng, Shuang Wu, Douglas J Bartels, John F Engelhardt

Hum Gene Ther· August 2023

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Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes.
Melissa S Putman, Andrew W Norris, Rebecca L Hull, Michael R Rickels, Lori Sussel, John F Engelhardt

Diabetes· June 2023

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Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes.
Melissa S Putman, Andrew W Norris, Rebecca L Hull, Michael R Rickels, Lori Sussel, John F Engelhardt

Diabetes Care· June 2023

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Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets.
David K Meyerholz, Mariah R Leidinger, J Adam Goeken, Thomas R Businga, Sebastian Vizuett, John F Engelhardt

BMC Res Notes· June 2023

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Orthotopic Ferret Tracheal Transplantation Using a Recellularized Bioengineered Graft Produces Functional Epithelia.
Albert C Pai, Anthony M Swatek, Thomas J Lynch, Bethany A Ahlers, Vitaly Ievlev, John F Engelhardt

Bioengineering (Basel)· June 2023

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Development and characterization of ferret tracheal injury and cell engraftment model.
Vitaly Ievlev, Albert C Pai, Drew S Dillon, Spencer Kuhl, Thomas J Lynch, John F Engelhardt

Front Med (Lausanne)· April 2023

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