Publications by authors named "John Isaacs"

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Skeletal muscle effects of Janus kinase inhibition in rheumatoid arthritis (RAMUS): a single-arm, experimental medicine study.
Joshua L Bennett, Kieren G Hollingsworth, Arthur G Pratt, Abbie E A Degnan, Gráinne S Gorman, John D Isaacs

Lancet Rheumatol· January 2026

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Patterns of steroid use in patients with established rheumatoid arthritis commencing treatment with biologic or targeted synthetic DMARDs.
Michael Stadler, Shae Bindra, Annie Cheung, Chuan Fu Yap, James Bluett, John D Isaacs

Rheumatol Adv Pract· January 2026

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Rheumatoid arthritis and osteoarthritis patients demonstrate comparable rates of major adverse cardiovascular events: a single-centre retrospective cohort study.
Chung M A Lin, Hadeel M Tabaqchali, Stephen White, Arthur G Pratt, John D Isaacs

Rheumatol Adv Pract· January 2026

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Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole-Blood Transcriptomics Data.
Chuan Fu Yap, Nisha Nair, Ann W Morgan, John D Isaacs, Anthony G Wilson

Arthritis Rheumatol· December 2025

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A phase 1 experimental medicine study of anti-CD3 monoclonal antibody in rheumatoid arthritis.
Catherine A Lawson, Rachel Harry, Bridget Griffiths, Geoff Hale, Herman Waldmann, John D Isaacs

Immunother Adv· December 2025

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Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.
Rajendra Kumar, Sheila Jonnatan, David E Sanin, Varsha Vakkala, Anoushka Kadam, John T Isaacs

Cancer Res· November 2025

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Early onset neutropenia in rituximab treated rheumatoid arthritis patients: a case series.
Chung Mun Alice Lin, Alice R Lorenzi, John D Isaacs, Faye A H Cooles

Rheumatol Adv Pract· September 2025

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Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis.
Nils Steinz, Tjardo D Maarseveen, Erik B van den Akker, Andrew P Cope, John D Isaacs

Ann Rheum Dis· August 2025

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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery and potential efficacy of autologous tolerogenic dendritic cell (TolDC) therapy for rheumatoid arthritis.
Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, John Isaacs

Trials· August 2025

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Pre-treatment GlycA measurement provides no additional predictive utility beyond routine clinical measures in patients with rheumatoid arthritis.
Stephanie F Ling, Chuan Fu Yap, Nisha Nair, Suzanne M M Verstappen, Ann W Morgan, John D Isaacs

Rheumatology (Oxford)· July 2025

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Endogenous Retroelement Activation is Implicated in Interferon-α Production and Anti-Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis.
Faye A H Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G Pratt, Ben Barron-Millar, John D Isaacs

Arthritis Rheumatol· June 2025

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Bruton's tyrosine kinase - A new target for immune mediated inflammatory diseases?
John D Isaacs

Semin Arthritis Rheum· June 2025

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Chasing the target: reports from the Advances in Targeted Therapies meeting, 2024.
Kevin L Winthrop, Joan Bathon, Andreas Kerschbaumer, John D Isaacs, Philip Mease

Ann Rheum Dis· June 2025

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Comparative Effectiveness of Abatacept Versus Adalimumab in Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis.
Chuan Fu Yap, Nisha Nair, Seema D Sharma, John Bowes, Amirah Binti Mohammad Ariff, John D Isaacs

Arthritis Rheumatol· June 2025

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Expert consensus statement on the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: 2024 update.
Peter Nash, Andreas Kerschbaumer, Victoria Konzett, Daniel Aletaha, Thomas Dörner, John D Isaacs

Ann Rheum Dis· May 2025

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The DESTINIES Study: an online Delphi study to build international consensus on the medical conditions and procedures that confer immunosuppression and their respective COVID-19 risk profiles.
Meredith Leston, José M Ordóñez-Mena, Mark Joy, F D Richard Hobbs, Simon de Lusignan, John Isaacs

EClinicalMedicine· May 2025

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Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance.
Helen Stark, Quan Yao Ho, Amy Cross, Alessandro Alessandrini, Alice Bertaina, John Isaacs

Transplantation· April 2025

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Patient-reported outcomes as early warning signs of flare following drug cessation in rheumatoid arthritis.
Leher Gumber, Fiona Rayner, Theophile Bigirumurame, Bernard Dyke, Andrew Melville, John D Isaacs

RMD Open· April 2025

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Clinical predictors of flare and drug-free remission in rheumatoid arthritis: preliminary results from the prospective BIO-FLARE experimental medicine study.
Fiona Rayner, Shaun Hiu, Andrew Melville, Theophile Bigirumurame, Amy Anderson, John Isaacs

BMJ Open· April 2025

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Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease.
Tegan McTaggart, Jing Xuan Lim, Katie J Smith, Bronagh Heaney, David McDonald, John Isaacs

J Biol Chem· January 2025

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trials.
Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, John D Isaacs

EClinicalMedicine· January 2025

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols.
Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, John D Isaacs

EClinicalMedicine· January 2025

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Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis.
Lucy MacDonald, Aziza Elmesmari, Domenico Somma, Jack Frew, Clara Di Mario, John D Isaacs

Immunity· December 2024

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Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.
Rajendra Kumar, Sheila Jonnatan, David E Sanin, Varsha Vakkala, Anoushka Kadam, John T Isaacs

medRxiv· December 2024

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