Publications by authors named "John Knox"

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Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, John E Knox

Cancer Discov· October 2025

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A neomorphic protein interface catalyzes covalent inhibition of RAS aspartic acid in tumors.
Caroline Weller, G Leslie Burnett, Lingyan Jiang, Sujata Chakraborty, Dongyu Zhang, John E Knox

Science· July 2025

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The "three body solution": Structural insights into molecular glues.
Aidan C A Tomlinson, John E Knox, Luc Brunsveld, Christian Ottmann, Jason K Yano

Curr Opin Struct Biol· April 2025

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Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers.
James Cregg, Kristof Pota, Aidan C A Tomlinson, Jason Yano, Abby Marquez, John E Knox

J Med Chem· March 2025

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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
James Cregg, Anne V Edwards, Stephanie Chang, Bianca J Lee, John E Knox

J Med Chem· March 2025

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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis.
Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, John Knox

Elife· January 2025

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Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, John E Knox

Cancer Discov· June 2024

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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, John E Knox

Nature· May 2024

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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Christopher J Schulze, Kyle J Seamon, Yulei Zhao, Yu C Yang, Jim Cregg, John E Knox

Science· August 2023

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Summer atmospheric circulation over Greenland in response to Arctic amplification and diminished spring snow cover.
Jonathon R Preece, Thomas L Mote, Judah Cohen, Lori J Wachowicz, John A Knox

Nat Commun· June 2023

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
G Leslie Burnett, Yu C Yang, James B Aggen, Jennifer Pitzen, Micah K Gliedt, John E Knox

J Med Chem· January 2023

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MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility.
John Knox, George Bou-Gharios, Kevin J Hamill, Colin E Willoughby

Genes (Basel)· August 2022

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Craterostigma plantagineum cell wall composition is remodelled during desiccation and the glycine-rich protein CpGRP1 interacts with pectins through clustered arginines.
Niklas U Jung, Valentino Giarola, Peilei Chen, John Paul Knox, Dorothea Bartels

Plant J· November 2019

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Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Kyle G Kroeck, Michael D Sacco, Emmanuel W Smith, Xiujun Zhang, Daniel Shoun, John E Knox

Sci Rep· October 2019

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The periodical cicada four-year acceleration hypothesis revisited and the polyphyletic nature of Brood V, including an updated crowd-source enhanced map (Hemiptera: Cicadidae: ).
John R Cooley, Nidia Arguedas, Elias Bonaros, Gerry Bunker, Stephen M Chiswell, John Knox

PeerJ· July 2018

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American football and fatal exertional heat stroke: a case study of Korey Stringer.
Andrew Grundstein, John A Knox, Jennifer Vanos, Earl R Cooper, Douglas J Casa

Int J Biometeorol· August 2017

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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Dustin Siegel, Hon C Hui, Edward Doerffler, Michael O Clarke, Kwon Chun, John Knox

J Med Chem· March 2017

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A retrospective analysis of American football hyperthermia deaths in the United States.
Andrew J Grundstein, Craig Ramseyer, Fang Zhao, Jordan L Pesses, Pete Akers, John A Knox

Int J Biometeorol· January 2012

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Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.
Mekonnen Kurabachew, Stephen H J Lu, Philipp Krastel, Esther K Schmitt, Bangalore L Suresh, John E Knox

J Antimicrob Chemother· October 2008

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Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Xiaojin Li, Ujjini H Manjunatha, Michael B Goodwin, John E Knox, Christopher A Lipinski

Bioorg Med Chem Lett· April 2008

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Yellow fever virus NS3 protease: peptide-inhibition studies.
Kristina Löhr, John E Knox, Wai Yee Phong, Ngai Ling Ma, Zheng Yin

J Gen Virol· August 2007

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Finding new medicines for flaviviral targets.
Thomas H Keller, Yen Liang Chen, John E Knox, Siew Pheng Lim, Ngai Ling Ma

Novartis Found Symp· March 2007

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Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors.
John E Knox, Ngai Ling Ma, Zheng Yin, Sejal J Patel, Wei-Ling Wang

J Med Chem· November 2006

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Experimental and theoretical study of the coordination of 1,2,4-triazolato, tetrazolato, and pentazolato ligands to the [K(18-crown-6)]+ fragment.
Issam Kobrsi, Wenjun Zheng, John E Knox, Mary Jane Heeg, H Bernhard Schlegel

Inorg Chem· October 2006

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Chemical failure modes of AlQ3-based OLEDs: AlQ3 hydrolysis.
John E Knox, Mathew D Halls, Hrant P Hratchian, H Bernhard Schlegel

Phys Chem Chem Phys· March 2006

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