Publications by authors named "John Kulp"

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Structural basis for sirtuin 2 activity and modulation: Current state and opportunities.
Samuel P Bernhard, Francesc X Ruiz, Stacy Remiszewski, Matthew J Todd, Thomas Shenk, John L Kulp

J Biol Chem· July 2025

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Computational Approaches to Predict Hepatitis B Virus Capsid Protein Mutations That Confer Resistance to Capsid Assembly Modulators.
Gideon Tolufashe, Usha Viswanathan, John Kulp, Ju-Tao Guo

Viruses· February 2025

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Potency of a small molecule that targets the molluscum contagiosum virus processivity factor increases when conjugated to a tripeptide.
Hancheng Guan, Manunya Nuth, Richard W Scott, Michael H Parker, Eric D Strobel, John L Kulp

Antiviral Res· June 2024

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Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly.
Nicky Hwang, Shuo Wu, Haiqun Ban, Huixin Luo, Julia Ma, John Kulp

Eur J Med Chem· November 2023

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BMaps: A Web Application for Fragment-Based Drug Design and Compound Binding Evaluation.
Daniel R Bryan, John L Kulp, Manoj K Mahapatra, Richard L Bryan, Usha Viswanathan, John L Kulp

J Chem Inf Model· July 2023

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An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity.
Kathryn L Roche, Stacy Remiszewski, Matthew J Todd, John L Kulp, Liudi Tang

J Clin Invest· June 2023

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A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential.
Hancheng Guan, Manunya Nuth, Stuart N Isaacs, Yuhong Xiao, Richard W Scott, John L Kulp

Antiviral Res· March 2023

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Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice.
Tadatoshi Sato, Christian D Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J Greenlee, John Kulp

Proc Natl Acad Sci U S A· December 2022

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4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators.
Nicky Hwang, Haiqun Ban, Shuo Wu, Kelly McGuire, Ellen Hernandez, John Kulp

Bioorg Med Chem Lett· February 2022

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Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators.
Yue Luo, Junjun Cheng, Zhanying Hu, Haiqun Ban, Shuo Wu, John Kulp

Antiviral Res· July 2021

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Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis.
Hancheng Guan, Manunya Nuth, Vivian Lee, Chenyan Lin, Claire H Mitchell, John L Kulp

Ocul Surf· January 2021

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Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus.
Nicky Hwang, Haiqun Ban, Junjun Chen, Julia Ma, Hui Liu, John Kulp

Med Chem Res· January 2021

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Profiling the circulating mRNA transcriptome in human liver disease.
Aejaz Sayeed, Brielle E Dalvano, David E Kaplan, Usha Viswanathan, John Kulp

Oncotarget· June 2020

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Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations.
Frank Guarnieri, John L Kulp, John L Kulp, Ian S Cloudsdale

PLoS One· March 2020

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Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist.
Xiaohui Zhang, Bowei Liu, Liudi Tang, Qing Su, Nicky Hwang, John Kulp

ACS Infect Dis· July 2019

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Discovery of Novel Hepatitis B Virus Nucleocapsid Assembly Inhibitors.
Xuexiang Zhang, Junjun Cheng, Julia Ma, Zhanying Hu, Shuo Wu, John Kulp

ACS Infect Dis· May 2019

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Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.
Manunya Nuth, Hancheng Guan, Yuhong Xiao, John L Kulp, Michael H Parker

Antiviral Res· February 2019

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CpAMs induce assembly of HBV capsids with altered electrophoresis mobility: Implications for mechanism of inhibiting pgRNA packaging.
Shuo Wu, Yue Luo, Usha Viswanathan, John Kulp, Junjun Cheng

Antiviral Res· November 2018

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High-performance nanomaterials formed by rigid yet extensible cyclic β-peptide polymers.
Kenan P Fears, Manoj K Kolel-Veetil, Daniel E Barlow, Noam Bernstein, Christopher R So, John L Kulp

Nat Commun· October 2018

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A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.
Bowei Liu, Liudi Tang, Xiaohui Zhang, Julia Ma, Mohit Sehgal, John Kulp

Antiviral Res· November 2017

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Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.
John L Kulp, Ian S Cloudsdale, John L Kulp, Frank Guarnieri

PLoS One· October 2017

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Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly.
Shuo Wu, Qiong Zhao, Pinghu Zhang, John Kulp, Lydia Hu

J Virol· August 2017

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Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.
Ian S Cloudsdale, John K Dickson, Thomas E Barta, Brian S Grella, Emilie D Smith, John L Kulp, John L Kulp

Bioorg Med Chem· August 2017

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A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.
Fang Guo, Shuo Wu, Justin Julander, Julia Ma, Xuexiang Zhang, John Kulp

J Virol· December 2016

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Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.
Lori A Emert-Sedlak, H Marie Loughran, Haibin Shi, John L Kulp, Sherry T Shu

Bioorg Med Chem Lett· March 2016

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