Publications by authors named "John Linley"

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SLC45A4 is a pain gene encoding a neuronal polyamine transporter.
Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng, John E Linley

Nature· October 2025

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Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model.
Chelsea Hopkins, Luis Fernandez de Castro, Julie Benthin, Marta Diaz-delCastillo, Pravallika Manjappa, John E Linley

J Bone Miner Res· June 2025

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Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.
Caroline M Kopruszinski, John E Linley, Peter Thornton, Alison S Walker, Philip Newton

Brain· April 2025

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Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.
Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng, John E Linley

bioRxiv· September 2024

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Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia.
Federico Iseppon, Ana P Luiz, John E Linley, John N Wood

eNeuro· February 2023

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Calcium imaging for analgesic drug discovery.
Federico Iseppon, John E Linley, John N Wood

Neurobiol Pain· January 2022

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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.
Wendy A Williams, John E Linley, Clare A Jones, Yoko Shibata, Arjan Snijder

Pain· September 2019

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Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies.
Caroline S Colley, Elizabeth England, John E Linley, Trevor C I Wilkinson

Curr Protoc Pharmacol· September 2018

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Mapping protein interactions of sodium channel Na1.7 using epitope-tagged gene-targeted mice.
Alexandros H Kanellopoulos, Jennifer Koenig, Honglei Huang, Martina Pyrski, Queensta Millet, John E Linley

EMBO J· February 2018

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Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia.
Jennifer Koenig, Robert Werdehausen, John E Linley, Abdella M Habib, Jeffrey Vernon

PLoS One· May 2016

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Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis.
Adel Al-Hazza, John Linley, Qadeer Aziz, Malcolm Hunter, Geoffrey Sandle

Biochem Biophys Res Commun· February 2016

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Recombinant expression and in vitro characterisation of active Huwentoxin-IV.
Isabelle Sermadiras, Jefferson Revell, John E Linley, Alan Sandercock, Peter Ravn

PLoS One· July 2014

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Evidence that two distinct crypt cell types secrete chloride and potassium in human colon.
John Linley, Arun Loganathan, Shashikala Kopanati, Geoffrey I Sandle, Malcolm Hunter

Gut· March 2014

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Perforated whole-cell patch-clamp recording.
John E Linley

Methods Mol Biol· September 2013

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Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia.
Roman Cregg, Bisola Laguda, Robert Werdehausen, James J Cox, John E Linley

Neuromolecular Med· June 2013

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Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.
Jefferson D Revell, Per-Eric Lund, John E Linley, Jacky Metcalfe, Nicole Burmeister

Peptides· June 2013

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Bradykinin controls pool size of sensory neurons expressing functional δ-opioid receptors.
Louisa Pettinger, Sylvain Gigout, John E Linley, Nikita Gamper

J Neurosci· June 2013

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Neurological perspectives on voltage-gated sodium channels.
Niels Eijkelkamp, John E Linley, Mark D Baker, Michael S Minett, Roman Cregg

Brain· September 2012

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Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.
John E Linley, Lezanne Ooi, Louisa Pettinger, Hannah Kirton, John P Boyle

Proc Natl Acad Sci U S A· June 2012

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TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.
Kathryn Quick, Jing Zhao, Niels Eijkelkamp, John E Linley, Francois Rugiero

Open Biol· May 2012

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Potential role of reduced basolateral potassium (IKCa3.1) channel expression in the pathogenesis of diarrhoea in ulcerative colitis.
Adel Al-Hazza, John E Linley, Qadeer Aziz, Kenneth A Maclennan, Malcolm Hunter

J Pathol· February 2012

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M channel enhancers and physiological M channel block.
John E Linley, Louisa Pettinger, Dongyang Huang, Nikita Gamper

J Physiol· February 2012

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Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability.
Mariusz Mucha, Lezanne Ooi, John E Linley, Pawel Mordaka, Carine Dalle

J Neurosci· October 2010

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Understanding inflammatory pain: ion channels contributing to acute and chronic nociception.
John E Linley, Kirstin Rose, Lezanne Ooi, Nikita Gamper

Pflugers Arch· April 2010

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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels.
Boyi Liu, John E Linley, Xiaona Du, Xuan Zhang, Lezanne Ooi

J Clin Invest· April 2010

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