Publications by authors named "John M Pascal"

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PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.
Mihaela Robu, Rashmi G Shah, Diana van den Heuvel, Yan Coulombe, Marc Bazin, John M Pascal

Nucleic Acids Res· November 2025

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PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair.
Marie-France Langelier, John M Pascal

DNA Repair (Amst)· October 2025

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Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.
Léonie Frigon, John M Pascal

J Biol Chem· June 2025

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A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.
Emily S Smith-Pillet, Ramya Billur, Marie-France Langelier, Tanaji T Talele, John M Pascal

Mol Cell· March 2025

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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.
Shang-Jung Cheng, Temitope Gafaar, Jijin R A Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, John M Pascal

Nat Commun· January 2025

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PARP enzyme de novo synthesis of protein-free poly(ADP-ribose).
Marie-France Langelier, Manija Mirhasan, Karine Gilbert, Aleksandr Sverzhinksy, Alexandra Furtos, John M Pascal

Mol Cell· December 2024

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Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Nicholas C K Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Seher Alam, John M Pascal

Nat Commun· December 2024

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A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.
Emily S Smith-Pillet, Ramya Billur, Marie-France Langelier, Tanaji T Talele, John M Pascal

bioRxiv· May 2024

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Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Uday Kiran Velagapudi, Élise Rouleau-Turcotte, Ramya Billur, Xuwei Shao, Manisha Patil, John M Pascal

Biochem J· March 2024

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ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification.
Élise Rouleau-Turcotte, John M Pascal

J Biol Chem· December 2023

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Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Léonie Frigon, John M Pascal

Nucleic Acids Res· December 2023

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PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance.
John M Pascal

Curr Opin Struct Biol· August 2023

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PARP1 associates with R-loops to promote their resolution and genome stability.
Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, John M Pascal

Nucleic Acids Res· March 2023

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Clinical PARP inhibitors allosterically induce PARP2 retention on DNA.
Marie-France Langelier, Xiaohui Lin, Shan Zha, John M Pascal

Sci Adv· March 2023

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Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Moriah R Arnold, Marie-France Langelier, Jessica Gartrell, Ilsa T Kirby, Daniel J Sanderson, John M Pascal

Cell Chem Biol· December 2022

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Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose).
Jijin R A Kuttiyatveetil, Heddy Soufari, Morgan Dasovich, Isabel R Uribe, Manija Mirhasan, John M Pascal

Cell Rep· October 2022

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A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.
Huijun Xue, Amit Bhardwaj, Yandong Yin, Carel Fijen, Anastasiya Ephstein, John M Pascal

Sci Adv· September 2022

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Unorthodox PCNA Binding by Chromatin Assembly Factor 1.
Amogh Gopinathan Nair, Nick Rabas, Sara Lejon, Caleb Homiski, Michael J Osborne, John M Pascal

Int J Mol Sci· September 2022

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Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Élise Rouleau-Turcotte, Dragomir B Krastev, Stephen J Pettitt, Christopher J Lord, John M Pascal

Mol Cell· August 2022

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Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro.
Elena Y Kotova, Fu-Kai Hsieh, Han-Wen Chang, Natalia V Maluchenko, Marie-France Langelier, John M Pascal

Int J Mol Sci· June 2022

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Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Aleksandr Sverzhinsky, Alan E Tomkinson, John M Pascal

Structure· March 2022

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Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cells.
Ishtiaque Rashid, Miaw-Sheue Tsai, Aleksandr Sverzhinsky, Aye Su Hlaing, Brian Shih, John M Pascal

Methods Mol Biol· March 2022

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HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Marie-France Langelier, Ramya Billur, Aleksandr Sverzhinsky, Ben E Black, John M Pascal

Nat Commun· November 2021

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Mechanisms of Nucleosome Reorganization by PARP1.
Natalya V Maluchenko, Dmitry K Nilov, Sergey V Pushkarev, Elena Y Kotova, Nadezhda S Gerasimova, John M Pascal

Int J Mol Sci· November 2021

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PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.
Yilun Sun, Jiji Chen, Shar-Yin N Huang, Yijun P Su, Wenjie Wang, John M Pascal

Nat Commun· August 2021

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