Publications by authors named "Dragomir B Krastev"

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Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers.
Roman M Chabanon, Liudmila Shcherbakova, Magali Lacroix-Triki, Marine Aglave, Jean Zeghondy, Dragomir B Krastev

Nat Commun· July 2025

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PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma.
James Stewart, Dragomir B Krastev, Rachel Brough, Diana Zatreanu, Feifei Song

Oncogene· March 2025

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Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.
Joseph S Baxter, Rachel Brough, Dragomir B Krastev, Feifei Song, Sandhya Sridhar

Mol Oncol· February 2024

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A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.
Stephen J Pettitt, Nan Shao, Diana Zatreanu, Jessica Frankum, Ilirjana Bajrami, Dragomir B Krastev

Oncogene· September 2023

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells.
Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Dragomir B Krastev

Cell Rep· May 2023

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SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.
Marta J Llorca-Cardenosa, Lauren I Aronson, Dragomir B Krastev, Jadwiga Nieminuszczy, John Alexander

Cancer Res· November 2022

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Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Élise Rouleau-Turcotte, Dragomir B Krastev, Stephen J Pettitt, Christopher J Lord, John M Pascal

Mol Cell· August 2022

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Opinion: PARP inhibitors in cancer-what do we still need to know?
Andrew J Wicks, Dragomir B Krastev, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord

Open Biol· July 2022

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Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.
Sara Vanessa Bernhard, Katarzyna Seget-Trzensiok, Christian Kuffer, Dragomir B Krastev, Lisa-Marie Stautmeister

Cell Oncol (Dordr)· February 2022

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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Dragomir B Krastev, Shudong Li, Yilun Sun, Andrew J Wicks, Gwendoline Hoslett

Nat Cell Biol· January 2022

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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency.
Ilirjana Bajrami, Callum Walker, Dragomir B Krastev, Daniel Weekes, Feifei Song

Commun Biol· November 2021

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PARP Inhibitors - Trapped in a Toxic Love Affair.
Dragomir B Krastev, Andrew J Wicks, Christopher J Lord

Cancer Res· November 2021

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Structural basis for allosteric PARP-1 retention on DNA breaks.
Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi, Mark A Hancock, Jamin D Steffen, Dragomir B Krastev

Science· April 2020

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PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
Roman M Chabanon, Gareth Muirhead, Dragomir B Krastev, Julien Adam, Daphné Morel

J Clin Invest· March 2019

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The shieldin complex mediates 53BP1-dependent DNA repair.
Sylvie M Noordermeer, Salomé Adam, Dheva Setiaputra, Marco Barazas, Stephen J Pettitt, Dragomir B Krastev

Nature· August 2018

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Stephen J Pettitt, Dragomir B Krastev, Inger Brandsma, Amy Dréan, Feifei Song

Nat Commun· May 2018

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Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Dragomir B Krastev, Stephen J Pettitt, James Campbell, Feifei Song, Barbara E Tanos

Nat Commun· May 2018

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DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.
Mehdi Touat, Tony Sourisseau, Nicolas Dorvault, Roman M Chabanon, Marlène Garrido, Dragomir B Krastev

J Clin Invest· April 2018

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E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N Pemberton, Dragomir B Krastev

Cancer Discov· April 2018

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ATR Is a Therapeutic Target in Synovial Sarcoma.
Samuel E Jones, Emmy D G Fleuren, Jessica Frankum, Asha Konde, Chris T Williamson, Dragomir B Krastev

Cancer Res· December 2017

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Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells.
Stephen J Pettitt, Dragomir B Krastev, Helen N Pemberton, Yari Fontebasso, Jessica Frankum

Sci Data· March 2017

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HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Dragomir Blazhev Krastev

EMBO J· June 2013

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Mammalian Ino80 mediates double-strand break repair through its role in DNA end strand resection.
Anastas Gospodinov, Thomas Vaissiere, Dragomir B Krastev, Gaëlle Legube, Boyka Anachkova

Mol Cell Biol· December 2011

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Ribosome biogenesis and p53: who is regulating whom?
Dragomir B Krastev, Frank Buchholz

Cell Cycle· October 2011

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A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly.
Dragomir B Krastev, Mikolaj Slabicki, Maciej Paszkowski-Rogacz, Nina C Hubner, Magno Junqueira

Nat Cell Biol· June 2011

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