Publications by authors named "John Randle"

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Chimeras Derived from a P2Y Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation.
Zhiwei Wen, Asmita Pramanik, Sarah A Lewicki, Young-Hwan Jung, Zhan-Guo Gao, John C R Randle

ACS Pharmacol Transl Sci· October 2024

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Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y Receptor Antagonists.
Zhiwei Wen, Asmita Pramanik, Sarah A Lewicki, Young-Hwan Jung, Zhan-Guo Gao, John C R Randle

J Med Chem· July 2023

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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2YR Antagonist.
Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B Phung, Varun Gopinatth, John C R Randle

J Med Chem· February 2022

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Structure-Activity Relationship of Heterocyclic P2Y Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres.
Young-Hwan Jung, Veronica Salmaso, Zhiwei Wen, John M Bennett, Ngan B Phung, John C R Randle

J Med Chem· April 2021

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Are re-injured ligaments equivalent mechanically to injured ligaments: The role of re-injury severity?
Johnathan L Sevick, Bryan J Heard, Ian Ky Lo, John A Randle, Cyril B Frank

Proc Inst Mech Eng H· July 2018

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Double-row repair of the distal attachment of the superficial medial collateral ligament: a basic science pilot study.
Daniel Whelan, Jeff Leiter, Treny Sasyniuk, Robert Litchfield, John Randle

Knee Surg Sports Traumatol Arthrosc· October 2015

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Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.
Jason A Campagna, Kevin Pojasek, David Grayzel, John Randle, Douglas E Raines

Anesthesiology· December 2014

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Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients.
Keyur Patel, Seng G Lim, Chow W Cheng, Eric Lawitz, Hans L Tillmann, John C R Randle

Antivir Ther· April 2012

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A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.
Bambang S Adiwijaya, Eva Herrmann, Brian Hare, Tara Kieffer, Chao Lin, John C R Randle

PLoS Comput Biol· April 2010

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Rapid decrease of wild-type hepatitis C virus on telaprevir treatment.
Bambang S Adiwijaya, Brian Hare, Paul R Caron, John Cr Randle, Avidan U Neumann

Antivir Ther· August 2009

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Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release.
Liliana Bernardino, Silvia Balosso, Teresa Ravizza, Nicola Marchi, George Ku, John C Randle

J Neurochem· July 2008

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(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.
Woods Wannamaker, Robert Davies, Mark Namchuk, John Pollard, Pamella Ford, John C R Randle

J Pharmacol Exp Ther· May 2007

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Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.
Teresa Ravizza, Sian-Marie Lucas, Silvia Balosso, Liliana Bernardino, George Ku, John C R Randle

Epilepsia· July 2006

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IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients.
Jeffrey H Stack, Kevin Beaumont, Paul D Larsen, Kimberly S Straley, Greg W Henkel, John C R Randle

J Immunol· August 2005

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Impaired release of IL-18 from fibroblast-like synoviocytes activated with protein I/II, a pathogen-associated molecular pattern from oral streptococci, results from defective translation of IL-18 mRNA in pro-IL-18.
Mirjam B Zeisel, Laurence A Neff, John Randle, Jean-Paul Klein, Jean Sibilia

Cell Microbiol· June 2004

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ACL transection influences mRNA levels for collagen type I and TNF-alpha in MCL scar.
Tokifumi Majima, Ian K Y Lo, John A Randle, Linda L Marchuk, Nigel G Shrive

J Orthop Res· May 2002

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