Publications by authors named "John Seubert"

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Matrix metalloproteinase inhibition protects against junctophilin-2 proteolysis during doxorubicin-induced cardiotoxicity.
Wesam Bassiouni, Brandon Y H Chan, Andrej Roczkowsky, Joshua W Kranrod, Zabed Mahmud, John M Seubert

Br J Pharmacol· September 2025

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Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer.
Zhiheng Zhang, Liye Fang, Hiroki Furukawa, Andy Huang, Joshua Kranrod, John M Seubert

Biochem Biophys Res Commun· September 2025

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Alterations of myocardial ketone metabolism in heart failure with preserved ejection fraction (HFpEF).
Qiuyu Sun, Cory S Wagg, Nathan Wong, Kaleigh Wei, Ezra B Ketema, John M Seubert

ESC Heart Fail· August 2025

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Alterations in mitochondria and cellular senescence in aged sEH null female kidneys.
Ala Yousef, Liye Fang, Mobina Heidari, Andy Huang, Patrick Kondraciuk, John M Seubert

Geroscience· July 2025

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Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.
Ahmed M Darwesh, Liye Fang, Tariq R Altamimi, K Lockhart Jamieson, Wesam Bassiouni, John M Seubert

Cardiovasc Res· April 2025

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Editorial: Targeting mitochondria in aging and disease.
Cara B Gonzales, John M Seubert, Antonio Marcus Paes

Front Pharmacol· March 2025

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MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.
Wesam Bassiouni, Zabed Mahmud, Thomas Simmen, John M Seubert, Richard Schulz

J Mol Cell Cardiol· January 2025

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Editorial: Cytochromes P450, their modulators and metabolites in cardiovascular function and disease.
Adeniyi M Adebesin, Richard Joseph Roman, William B Campbell, John M Seubert, Rheem A Totah

Front Pharmacol· December 2024

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The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart.
Ala Yousef, Liye Fang, Mobina Heidari, Joshua Kranrod, John M Seubert

Front Pharmacol· December 2024

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Linoleic acid-derived diol 12,13-DiHOME enhances NLRP3 inflammasome activation in macrophages.
Robert Valencia, Joshua W Kranrod, Liye Fang, Amro M Soliman, Brandon Azer, John M Seubert

FASEB J· July 2024

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Cardioprotective response and senescence in aged sEH null female mice exposed to LPS.
Ala Yousef, Deanna K Sosnowski, Liye Fang, Renald James Legaspi, Jacob Korodimas, John M Seubert

Am J Physiol Heart Circ Physiol· June 2024

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Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids.
Joshua Kranrod, Anne Konkel, Robert Valencia, Ahmed M Darwesh, Robert Fischer, John M Seubert

J Biol Chem· June 2024

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Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells.
Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, John Seubert

Cell Death Discov· April 2024

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Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent.
Joshua W Kranrod, Ahmed M Darwesh, Wesam Bassiouni, Andy Huang, Liye Fang, John M Seubert

J Cardiovasc Pharmacol· January 2024

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Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis.
Keshav Gopal, Abdualrahman Mohammed Abdualkader, Xiaobei Li, Amanda A Greenwell, Qutuba G Karwi, John M Seubert

J Biol Chem· December 2023

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Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury.
Wesam Bassiouni, Robert Valencia, Zabed Mahmud, John M Seubert, Richard Schulz

Basic Res Cardiol· July 2023

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Loss of PI3Kα Mediates Protection From Myocardial Ischemia-Reperfusion Injury Linked to Preserved Mitochondrial Function.
Pavel Zhabyeyev, Brent McLean, Wesam Bassiouni, Robert Valencia, Manish Paul, John M Seubert

J Am Heart Assoc· June 2023

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Preface.
Darryl C Zeldin, John M Seubert

Adv Pharmacol· May 2023

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Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway.
Preetinder K Aujla, Mei Hu, Bridgette Hartley, Joshua W Kranrod, Anissa Viveiros, John M Seubert

Hypertension· January 2023

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PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells.
Natsumi Miyazaki, Reika Shiratori, Taichi Oshima, Zhiheng Zhang, Robert Valencia, John M Seubert

Biochem Biophys Res Commun· October 2022

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Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function.
Deanna K Sosnowski, K Lockhart Jamieson, Artiom Gruzdev, Yingxi Li, Robert Valencia, John M Seubert

Am J Physiol Heart Circ Physiol· October 2022

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Cardiomyocyte-specific CYP2J2 and its therapeutic implications.
Robert Valencia, Wesam Bassiouni, Ahmed M Darwesh, Raj Bapuji, John M Seubert

Expert Opin Drug Metab Toxicol· September 2022

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Myocardial Iron Deficiency and Mitochondrial Dysfunction in Advanced Heart Failure in Humans.
Hao Zhang, K Lockhart Jamieson, Justin Grenier, Anish Nikhanj, Zeyu Tang, John M Seubert

J Am Heart Assoc· June 2022

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Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy.
Deanna K Sosnowski, K Lockhart Jamieson, Ahmed M Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, John M Seubert

Front Cardiovasc Med· May 2022

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Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility.
Anissa Viveiros, Mahmoud Gheblawi, Preetinder K Aujla, Deanna K Sosnowski, John M Seubert

J Mol Cell Cardiol· March 2022

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