Publications by authors named "Thomas Simmen"

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The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Junsheng Chen, Megan C Yap, Arthur Bassot, Danielle M Pascual, Tadashi Makio, Thomas Simmen

Cell Rep· November 2025

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Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.
Aislinn D Maguire, Shawn M Lamothe, Muhammad Saad Yousuf, Kree Goss, Jayadeep Rao, Thomas Simmen

Anesthesiology· July 2025

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A lipid in transit - the journey of cholesterol into the heart of mitochondrial research.
Thomas Simmen, Luca Pellegrini

J Cell Sci· May 2025

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MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.
Wesam Bassiouni, Zabed Mahmud, Thomas Simmen, John M Seubert, Richard Schulz

J Mol Cell Cardiol· January 2025

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ER stress as a sentinel mechanism for ER Ca homeostasis.
Tadashi Makio, Junsheng Chen, Thomas Simmen

Cell Calcium· December 2024

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Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering.
Tadashi Makio, Thomas Simmen

Contact (Thousand Oaks)· July 2024

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Ironing out the mitochondria.
Junsheng Chen, Tadashi Makio, Thomas Simmen

Nat Chem Biol· June 2024

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SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
Serena Germani, Andrew Tri Van Ho, Alessandro Cherubini, Ersilia Varone, Alexander Chernorudskiy, Thomas Simmen

Cell Rep Med· March 2024

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Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca dynamics linked to DEE66.
Truong Thi My Nhung, Nguyen Phuoc Long, Tran Diem Nghi, Yeongjun Suh, Nguyen Hoang Anh, Thomas Simmen

Proc Natl Acad Sci U S A· August 2023

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The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria.
Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C Yap, Christine Silvia Gibhardt, Thomas Simmen

Cell Rep· January 2023

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LUBAC and NF-κB trigger a nuclear response from mitochondria.
Junsheng Chen, Thomas Simmen

EMBO J· December 2022

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Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.
Sameera Zia, Brady P Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S Baaklini, Thomas Simmen

Mol Neurodegener· December 2022

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Astrocytes show increased levels of Ero1α in multiple sclerosis and its experimental autoimmune encephalomyelitis animal model.
Samira Samtleben, Lucas Mina, Megan C Yap, William G Branton, Muhammad Saad Yousuf, Thomas Simmen

Eur J Neurosci· October 2022

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S-Palmitoylation of calcineurin β1 connects cellular Ca homeostasis to phosphatidylinositol 4-kinase activity at the plasma membrane.
Arthur Bassot, Lucas Mina, Junsheng Chen, Thomas Simmen

Cell Calcium· May 2022

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Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins.
Maria Sol Herrera-Cruz, Megan C Yap, Nasser Tahbaz, Keelie Phillips, Laurel Thomas, Thomas Simmen

Biol Direct· November 2021

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Endoplasmic reticulum-mitochondria interplay in chronic pain: The calcium connection.
Muhammad Saad Yousuf, Aislinn D Maguire, Thomas Simmen, Bradley J Kerr

Mol Pain· July 2021

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Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs).
Junsheng Chen, Arthur Bassot, Fabrizio Giuliani, Thomas Simmen

Cells· July 2021

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Post-Translational Modification of Cysteines: A Key Determinant of Endoplasmic Reticulum-Mitochondria Contacts (MERCs).
Arthur Bassot, Junsheng Chen, Thomas Simmen

Contact (Thousand Oaks)· March 2021

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The Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction.
Hong Qi, Xiang Li, Zhen Jin, Thomas Simmen, Jianwei Shuai

iScience· November 2020

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Endoplasmic reticulum stress in the dorsal root ganglia regulates large-conductance potassium channels and contributes to pain in a model of multiple sclerosis.
Muhammad Saad Yousuf, Samira Samtleben, Shawn M Lamothe, Timothy N Friedman, Ana Catuneanu, Thomas Simmen

FASEB J· September 2020

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The ER chaperone calnexin controls mitochondrial positioning and respiration.
Tomás Gutiérrez, Hong Qi, Megan C Yap, Nasser Tahbaz, Leanne A Milburn, Thomas Simmen

Sci Signal· June 2020

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Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.
Roberto Bravo-Sagua, Valentina Parra, Carolina Ortiz-Sandoval, Mario Navarro-Marquez, Andrea E Rodríguez, Thomas Simmen

Cell Death Differ· November 2019

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Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism.
Yuxiang Fan, Thomas Simmen

Cells· September 2019

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Redox signals at the ER-mitochondria interface control melanoma progression.
Xin Zhang, Christine S Gibhardt, Thorsten Will, Hedwig Stanisz, Christina Körbel, Thomas Simmen

EMBO J· August 2019

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Coming together to define membrane contact sites.
Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Thomas Simmen

Nat Commun· March 2019

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