Publications by authors named "Jolyon Mitchell"

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Multi-Participant Blinded Investigation into Internal Losses of Medication in Commercially Available Mixing Inlets: Testing Different Orally Inhaled Product Classes Following Pharmacopeial Methods.
Patrik U Andersson, Jim Clay, Mark Parry, Teresa Iley, Daryl L Roberts, Jolyon P Mitchell

J Aerosol Med Pulm Drug Deliv· December 2025

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The Fundamentals of the Analysis of Cascade Impactor Data for the Characterization of Aerodynamic Particle Size Distributions (APSDs) in the Testing of Orally Inhaled Drug Products (OIPs).
Daryl L Roberts, Jolyon P Mitchell

AAPS PharmSciTech· September 2025

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Proposals for Global Harmonization of Regulations for Testing of Spacers and Valved Holding Chambers for Pressurized Metered Dose Inhalers.
Jolyon P Mitchell

AAPS PharmSciTech· April 2025

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Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment.
Judy Schloss, Dominic P Coppolo, Jason A Suggett, Mark W Nagel, Jolyon P Mitchell

Pulm Ther· June 2024

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Laboratory Performance Testing of Aqueous Nasal Inhalation Products for Droplet/Particle Size Distribution: an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS).
William H Doub, Julie M Suman, Mark Copley, Adrian P Goodey, Sana Hosseini, Jolyon P Mitchell

AAPS PharmSciTech· October 2023

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Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS).
Jolyon P Mitchell, I Carter, J D Christopher, M Copley, W H Doub

AAPS PharmSciTech· March 2023

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Moving Forward from "Fine Particle Fraction: The Good and the Bad".
Jolyon P Mitchell, William Doub, J David Christopher, Christopher J Gruenloh, Rajni B Patel

J Aerosol Med Pulm Drug Deliv· August 2022

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Non-Pharmaceutical Techniques for Obstructive Airway Clearance Focusing on the Role of Oscillating Positive Expiratory Pressure (OPEP): A Narrative Review.
Dominic P Coppolo, Judy Schloss, Jason A Suggett, Jolyon P Mitchell

Pulm Ther· March 2022

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Particle Size Measurements from Orally Inhaled and Nasal Drug Products.
Jolyon P Mitchell

J Aerosol Med Pulm Drug Deliv· December 2021

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Internal Volumes of Pharmaceutical Compendial Induction Port, Next-Generation Impactor With and Without Its Pre-separator, and Several Configurations of the Andersen Cascade Impactor With and Without Pre-separator.
Daryl L Roberts, Frank Chambers, Mark Copley, Jolyon P Mitchell

J Aerosol Med Pulm Drug Deliv· August 2020

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Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group.
Jolyon P Mitchell, Ariel Berlinski, Sebastian Canisius, David Cipolla, Myrna B Dolovich

J Aerosol Med Pulm Drug Deliv· August 2020

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Addressing the Need for Controls on Particle Bounce and Re-entrainment in the Cascade Impactor and for the Mitigation of Electrostatic Charge for Aerodynamic Particle Size Assessment of Orally Inhaled Products: an Assessment by the International Consortium on Regulation and Science (IPAC-RS).
William Doub, Stephen Stein, Jolyon Mitchell, Adrian P Goodey

AAPS PharmSciTech· August 2020

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Reflections on Digital Health Tools for Respiratory Applications.
Andy Dundon, David Cipolla, Jolyon Mitchell, Svetlana Lyapustina

J Aerosol Med Pulm Drug Deliv· June 2020

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Innovative preclinical models for pulmonary drug delivery research.
Stephan Ehrmann, Otmar Schmid, Chantal Darquenne, Barbara Rothen-Rutishauser, Josue Sznitman, Jolyon Mitchell

Expert Opin Drug Deliv· April 2020

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Determination of Passive Dry Powder Inhaler Aerodynamic Particle Size Distribution by Multi-Stage Cascade Impactor: International Pharmaceutical Aerosol Consortium on Regulation & Science (IPAC-RS) Recommendations to Support Both Product Quality Control and Clinical Programs.
Jolyon P Mitchell, Stephen W Stein, William Doub, Adrian P Goodey, J David Christopher

AAPS PharmSciTech· May 2019

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Measurement of Aerodynamic Particle Size Distribution of Orally Inhaled Products by Cascade Impactor: How to Let the Product Specification Drive the Quality Requirements of the Cascade Impactor.
Daryl L Roberts, Jolyon P Mitchell

AAPS PharmSciTech· January 2019

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Development of a novel digital breath-activated inhaler: Initial particle size characterization and clinical testing.
Steven Kesten, Elliot Israel, Guangxi Li, Jolyon Mitchell, Robert Wise

Pulm Pharmacol Ther· December 2018

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Evaluation of Nasal Inlet Ports Having Simplified Geometry for the Pharmacopeial Assessment of Mass Fraction of Dose Likely to Penetrate Beyond the Nasopharynx: a Preliminary Investigation.
Gerallt Williams, Chris Blatchford, Jolyon P Mitchell

AAPS PharmSciTech· November 2018

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Re: "Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal" by Hillyer et al. (J Aerosol Med Pulm Drug Deliv. 2018 [31(2):111-113]; DOI: 10/1089/jamp.2017.1396).
Myrna B Dolovich, Jolyon P Mitchell, Daryl L Roberts

J Aerosol Med Pulm Drug Deliv· August 2018

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Laboratory Study Comparing Pharmacopeial Testing of Nebulizers with Evaluation Based on Nephele Mixing Inlet Methodology.
Mårten Svensson, Elna Berg, Jolyon Mitchell, Dennis Sandell

AAPS PharmSciTech· February 2018

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Development and Evaluation of a Family of Human Face and Upper Airway Models for the Laboratory Testing of Orally Inhaled Products.
Mark W Nagel, Jason A Suggett, Dominic P Coppolo, Jolyon P Mitchell

AAPS PharmSciTech· November 2017

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Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI Aerosol.
J David Christopher, Rajni B Patel, Jolyon P Mitchell, Terrence P Tougas, Adrian P Goodey

AAPS PharmSciTech· November 2017

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Remarks on the article "Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler dry-powder inhaler" by Abadelah, et al., volume 104, page 180-87 (2017).
Daryl L Roberts, Jolyon P Mitchell

Eur J Pharm Sci· November 2017

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A Comparison of the Performance of Efficient Data Analysis Versus Fine Particle Dose as Metrics for the Quality Control of Aerodynamic Particle Size Distributions of Orally Inhaled Pharmaceuticals.
Terrence P Tougas, Adrian P Goodey, Gareth Hardwell, Jolyon Mitchell, Svetlana Lyapustina

AAPS PharmSciTech· February 2017

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Clinically Relevant In Vitro Testing of Orally Inhaled Products-Bridging the Gap Between the Lab and the Patient.
Jolyon P Mitchell, Jason Suggett, Mark Nagel

AAPS PharmSciTech· August 2016

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