Publications by authors named "David Cipolla"

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Inhalable and Nasal Biologics: Analytical, Formulation, Development, and Regulatory Considerations.
David Cipolla, Christopher J Gruenloh, Nani Kadrichu, Philip J Kuehl, Lei Mao

J Aerosol Med Pulm Drug Deliv· October 2025

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History of the International Society of Aerosols in Medicine (ISAM): Celebrating the 25th Congress.
Barbara Rothen-Rutishauser, Chantal Darquenne, David Cipolla, Omar Usmani

J Aerosol Med Pulm Drug Deliv· June 2025

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Broad Immunomodulatory Effects of the Dipeptidyl Peptidase-1 Inhibitor Brensocatib in Bronchiectasis: Data from the Phase 2, Double-Blind, Placebo-controlled WILLOW Trial.
Emma D Johnson, Merete B Long, Lidia Perea, Vivian H Shih, Carlos Fernandez, David Cipolla

Am J Respir Crit Care Med· May 2025

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Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.
Michel R Corboz, Tam L Nguyen, Andy Stautberg, David Cipolla, Walter R Perkins

J Aerosol Med Pulm Drug Deliv· October 2024

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Treprostinil palmitil inhalation powder leverages endogenous lung enzymes to provide sustained treprostinil.
Tam Nguyen, Christina Chang, David Cipolla, Vladimir Malinin, Walter Perkins

Expert Opin Drug Deliv· August 2024

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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block granzyme-mediated target cell killing by CD8 T or NK cells.
Vivien R Sutton, Sally V Watt, Hedieh Akhlaghi, David C Cipolla, Kuan-Ju Chen

Front Pharmacol· July 2024

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Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis.
Patrick P McDonald, Franziska Graf Leifer, Jessica Basso, Dan Lasala, Dedong Li, David C Cipolla

Front Immunol· August 2023

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Preclinical Investigation of a Lipoglycopeptide Dry Powder Inhalation Therapy for the Treatment of Pulmonary MRSA Infection.
Donna M Konicek, Adam J Plaunt, Sachin Gharse, Sasha J Rose, Arielle Dorfman, David Cipolla

Pharmaceutics· August 2023

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Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice.
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, David C Cipolla

Front Immunol· July 2023

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The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala, David C Cipolla

Front Pharmacol· July 2023

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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial.
David Cipolla, Jimin Zhang, Brice Korkmaz, James D Chalmers, Jessica Basso

Respir Res· May 2023

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Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder.
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S Malinin, Walter R Perkins, David Cipolla

Pharmaceutics· March 2023

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Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, David Cipolla

Antimicrob Agents Chemother· November 2022

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Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Michel R Corboz, Adam J Plaunt, Vladimir S Malinin, Zhili Li, Helena Gauani, David Cipolla

J Pharmacol Exp Ther· October 2022

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An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells.
Jessica Basso, Jimin Zhang, Daniel Lasala, Sasha J Rose, Kuan-Ju Chen, David Cipolla

PLoS One· September 2022

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Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension.
Michel R Corboz, Adam J Plaunt, Vladimir Malinin, Zhili Li, Helena Gauani, David Cipolla

Eur J Pharmacol· February 2022

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Inhaled Medicines: Past, Present, and Future.
Sandra Anderson, Paul Atkins, Per Bäckman, David Cipolla, Andrew Clark

Pharmacol Rev· January 2022

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Strategies to Overcome Biological Barriers Associated with Pulmonary Drug Delivery.
Adam J Plaunt, Tam L Nguyen, Michel R Corboz, Vladimir S Malinin, David C Cipolla

Pharmaceutics· January 2022

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Robustness of aerosol delivery of amikacin liposome inhalation suspension using the eFlow® Technology.
Zhili Li, Walter Perkins, David Cipolla

Eur J Pharm Biopharm· September 2021

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Recent advances in prodrug-based nanoparticle therapeutics.
Kuan-Ju Chen, Adam J Plaunt, Franziska G Leifer, Jeong Yeon Kang, David Cipolla

Eur J Pharm Biopharm· August 2021

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Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes.
Isra Khatib, Wei-Ren Ke, David Cipolla, Hak-Kim Chan

Int J Pharm· August 2021

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, David Cipolla

Antimicrob Agents Chemother· June 2021

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Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design.
Isra Khatib, Michael Y T Chow, Juanfang Ruan, David Cipolla, Hak-Kim Chan

Int J Pharm· March 2021

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Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension.
Adam J Plaunt, Sadikul Islam, Tony Macaluso, Helena Gauani, Thomas Baker, David C Cipolla

Int J Mol Sci· January 2021

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Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.
Richard W Chapman, Michel R Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, David Cipolla

ERJ Open Res· January 2021

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