Publications by authors named "Daniel Lasala"

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An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates.
Beryl B Cummings, Page R Bouchard, Mark N Milton, Peter F Moesta, Vyas Ramanan, Daniel LaSala

EBioMedicine· July 2025

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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block granzyme-mediated target cell killing by CD8 T or NK cells.
Vivien R Sutton, Sally V Watt, Hedieh Akhlaghi, David C Cipolla, Kuan-Ju Chen, Daniel LaSala

Front Pharmacol· July 2024

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Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice.
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun

Front Immunol· July 2023

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The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala

Front Pharmacol· July 2023

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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial.
David Cipolla, Jimin Zhang, Brice Korkmaz, James D Chalmers, Jessica Basso, Daniel Lasala

Respir Res· May 2023

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Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala

Antimicrob Agents Chemother· November 2022

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An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells.
Jessica Basso, Jimin Zhang, Daniel Lasala, Sasha J Rose, Kuan-Ju Chen

PLoS One· September 2022

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala

Antimicrob Agents Chemother· June 2021

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Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Michel R Corboz, William Salvail, Sandra Gagnon, Daniel LaSala, Charles E Laurent

Prostaglandins Other Lipid Mediat· February 2021

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Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats.
Michel R Corboz, Jimin Zhang, Daniel LaSala, Keith DiPetrillo, Zhili Li

Pulm Pharmacol Ther· April 2018

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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
Ken Yamada, Margaret Brousseau, Wataru Honma, Akiko Iimura, Hidetomo Imase, Daniel LaSala

J Med Chem· October 2017

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Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
Ken Yamada, Ji-Hu Zhang, Xiaoling Xie, Juergen Reinhardt, Amy Qiongshu Xie, Daniel LaSala

ACS Chem Biol· December 2016

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Small-molecule WNK inhibition regulates cardiovascular and renal function.
Ken Yamada, Hyi-Man Park, Dean F Rigel, Keith DiPetrillo, Erin J Whalen, Daniel LaSala

Nat Chem Biol· November 2016

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Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Julien P N Papillon, Changgang Lou, Alok K Singh, Christopher M Adams, Gary M Ksander, Daniel LaSala

J Med Chem· December 2015

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Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Julien P N Papillon, Christopher M Adams, Qi-Ying Hu, Changgang Lou, Alok K Singh, Daniel LaSala

J Med Chem· June 2015

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Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.
Joël Ménard, Dean F Rigel, Catherine Watson, Arco Y Jeng, Fumin Fu, Daniel LaSala

J Transl Med· December 2014

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Erik L Meredith, Gary Ksander, Lauren G Monovich, Julien P N Papillon, Qian Liu, Daniel LaSala

ACS Med Chem Lett· December 2013

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Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Daniel LaSala, Yasuhiko Shibanaka, Arco Y Jeng

Anal Biochem· November 2009

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Optimization of halopemide for phospholipase D2 inhibition.
Lauren Monovich, Benjamin Mugrage, Elizabeth Quadros, Karen Toscano, Ruben Tommasi, Daniel LaSala

Bioorg Med Chem Lett· April 2007

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