Publications by authors named "Walter Perkins"

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Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.
Michel R Corboz, Tam L Nguyen, Andy Stautberg, David Cipolla, Walter R Perkins

J Aerosol Med Pulm Drug Deliv· October 2024

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Treprostinil palmitil inhalation powder leverages endogenous lung enzymes to provide sustained treprostinil.
Tam Nguyen, Christina Chang, David Cipolla, Vladimir Malinin, Walter Perkins

Expert Opin Drug Deliv· August 2024

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Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis.
Patrick P McDonald, Franziska Graf Leifer, Jessica Basso, Dan Lasala, Dedong Li, Walter R Perkins

Front Immunol· August 2023

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Preclinical Investigation of a Lipoglycopeptide Dry Powder Inhalation Therapy for the Treatment of Pulmonary MRSA Infection.
Donna M Konicek, Adam J Plaunt, Sachin Gharse, Sasha J Rose, Arielle Dorfman, Walter R Perkins

Pharmaceutics· August 2023

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Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice.
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Walter R Perkins

Front Immunol· July 2023

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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial.
David Cipolla, Jimin Zhang, Brice Korkmaz, James D Chalmers, Jessica Basso, Walter R Perkins

Respir Res· May 2023

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Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder.
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S Malinin, Walter R Perkins

Pharmaceutics· March 2023

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Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, Walter R Perkins

Antimicrob Agents Chemother· November 2022

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Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Michel R Corboz, Adam J Plaunt, Vladimir S Malinin, Zhili Li, Helena Gauani, Walter R Perkins

J Pharmacol Exp Ther· October 2022

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Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension.
Michel R Corboz, Adam J Plaunt, Vladimir Malinin, Zhili Li, Helena Gauani, Walter R Perkins

Eur J Pharmacol· February 2022

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Robustness of aerosol delivery of amikacin liposome inhalation suspension using the eFlow® Technology.
Zhili Li, Walter Perkins, David Cipolla

Eur J Pharm Biopharm· September 2021

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Adam J Plaunt, Sasha J Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, Walter R Perkins

Antimicrob Agents Chemother· June 2021

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Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Michel R Corboz, William Salvail, Sandra Gagnon, Daniel LaSala, Charles E Laurent, Walter R Perkins

Prostaglandins Other Lipid Mediat· February 2021

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Treprostinil palmitil, an inhaled long-acting pulmonary vasodilator, does not show tachyphylaxis with daily dosing in rats.
Richard W Chapman, Zhili Li, Donald Chun, Helena Gauani, Vladimir Malinin, Walter R Perkins

Pulm Pharmacol Ther· February 2021

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Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension.
Adam J Plaunt, Sadikul Islam, Tony Macaluso, Helena Gauani, Thomas Baker, Walter R Perkins

Int J Mol Sci· January 2021

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Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.
Richard W Chapman, Michel R Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Walter Perkins

ERJ Open Res· January 2021

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An overview of the biology of a long-acting inhaled treprostinil prodrug.
Richard W Chapman, Michel R Corboz, Vladimir S Malinin, Adam J Plaunt, Donna M Konicek, Walter R Perkins

Pulm Pharmacol Ther· December 2020

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Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation.
Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Walter R Perkins

Drug Res (Stuttg)· November 2018

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Amikacin Liposome Inhalation Suspension (ALIS) Penetrates Non-tuberculous Mycobacterial Biofilms and Enhances Amikacin Uptake Into Macrophages.
Jimin Zhang, Franziska Leifer, Sasha Rose, Dung Yu Chun, Jill Thaisz, Walter R Perkins

Front Microbiol· May 2018

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Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats.
Michel R Corboz, Jimin Zhang, Daniel LaSala, Keith DiPetrillo, Zhili Li, Walter R Perkins

Pulm Pharmacol Ther· April 2018

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Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Walter R Perkins

Pulm Pharmacol Ther· April 2018

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Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
Michel R Corboz, Zhili Li, Vladimir Malinin, Adam J Plaunt, Donna M Konicek, Walter R Perkins

J Pharmacol Exp Ther· December 2017

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Pulmonary Deposition and Elimination of Liposomal Amikacin for Inhalation and Effect on Macrophage Function after Administration in Rats.
Vladimir Malinin, Mary Neville, Gina Eagle, Renu Gupta, Walter R Perkins

Antimicrob Agents Chemother· November 2016

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(99m)Tc-labeled therapeutic inhaled amikacin loaded liposomes.
Jae-Ho Lee, Kenneth T Cheng, Vladimir Malinin, Zhili Li, Zhengsheng Yao, Walter R Perkins

J Liposome Res· December 2013

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Performance of PARI eFlow.
Walter Perkins

J Aerosol Med Pulm Drug Deliv· April 2010

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