Publications by authors named "Jonathan A Fletcher"

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Future Directions and Priorities for Cellular Therapy in Sarcoma: A Report from the Strategic Advances in Sarcoma Science Cell Therapy Breakout.
Jacqueline Oliva-Ramirez, David Milewski, Lauren Banks, Kelly M Bailey, Everett J Moding, Jonathan A Fletcher

Cancers (Basel)· September 2025

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The activated tyrosine kinase ACK1 by multiple receptor tyrosine kinases promotes proliferation and invasion of mesothelioma via regulation of PI3K/AKT/mTOR and RAF/MAPK signaling pathways.
Yue Qiao, Shuihao Zhu, Zhenni Liu, Natalia Kelley, Zhencang Zheng, Jonathan A Fletcher

Cancer Gene Ther· June 2025

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Ferroptosis as a therapeutic vulnerability in MDM2 inhibition in dedifferentiated liposarcoma.
Chueh-Chuan Yen, Paul Chih-Hsueh Chen, San-Chi Chen, Wen-Chi Wu, Chiao-Han Yen, Jonathan A Fletcher

Oncol Lett· June 2025

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Reply to Y. Xia et al.
Sebastian Bauer, Jonathan A Fletcher, Daniel Rauh, Johanna Falkenhorst, Thomas Mühlenberg

J Clin Oncol· September 2024

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KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.
Thomas Mühlenberg, Johanna Falkenhorst, Tom Schulz, Benjamin S Fletcher, Alina Teuber, Jonathan A Fletcher

J Clin Oncol· April 2024

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Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma.
Adrian Marino-Enriquez, Jan Philipp Novotny, Doga C Gulhan, Isabella Klooster, Antuan V Tran, Jonathan A Fletcher

Clin Cancer Res· December 2023

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Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor.
Michael C Heinrich, Christopher L Corless, George D Demetri, Charles D Blanke, Margaret von Mehren, Christopher D M Fletcher, Jonathan A Fletcher

J Clin Oncol· November 2023

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Targeting DNA-PK.
Jan Philipp Novotny, Adrian Mariño-Enríquez, Jonathan A Fletcher

Cancer Treat Res· November 2023

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SETDB1 tumour suppressor roles in near-haploid mesothelioma involve TP53.
Mengting Xu, Yuqing Tu, Wenhui Bi, Meijun Z Lundberg, Isabella Klooster, Jonathan A Fletcher

Br J Cancer· August 2023

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Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Jonathan A Fletcher

iScience· February 2023

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Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma.
Elisa Fiorito, Patrycja Szybowska, Ellen M Haugsten, Michal Kostas, Geir F Øy, Jonathan A Fletcher

Br J Cancer· November 2022

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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST.
Inga-Marie Schaefer, Matthew L Hemming, Meijun Z Lundberg, Matthew P Serrata, Isabel Goldaracena, Jonathan A Fletcher

Br J Cancer· November 2022

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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.
Amish J Patel, Sarah Warda, Jesper L V Maag, Rohan Misra, Miguel A Miranda-Román, Jonathan A Fletcher

Cancer Discov· September 2022

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Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers.
Suzanne George, Margaret von Mehren, Jonathan A Fletcher, Jichao Sun, Sen Zhang

Clin Cancer Res· April 2022

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E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor.
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, Jonathan A Fletcher

Oncogene· December 2021

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Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas.
Inga-Marie Schaefer, Meijun Z Lundberg, Elizabeth G Demicco, Joanna Przybyl, Magdalena Matusiak, Jonathan A Fletcher

Cancer· August 2021

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E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
Ke Li, Xufen Zheng, Hua Tang, Yuan-Sheng Zang, Chunling Zeng, Jonathan A Fletcher

J Exp Med· August 2021

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YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways.
Wen-Bin Ou, Meijun Z Lundberg, Shuihao Zhu, Nacef Bahri, Anastasios Kyriazoglou, Jonathan A Fletcher

Oncogenesis· May 2021

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Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST).
Mazen A Atiq, Jessica L Davis, Jason L Hornick, Brendan C Dickson, Christopher D M Fletcher, Jonathan A Fletcher

Mod Pathol· January 2021

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Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain.
Susanne Grunewald, Lillian R Klug, Thomas Mühlenberg, Jonas Lategahn, Johanna Falkenhorst, Jonathan A Fletcher

Cancer Discov· January 2021

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Loss of SFRP1 expression is a key progression event in gastrointestinal stromal tumor pathogenesis.
Cher-Wei Liang, Ching-Yao Yang, Richard Flavin, Jonathan A Fletcher, Tzu-Pin Lu

Hum Pathol· January 2021

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AXL Inactivation Inhibits Mesothelioma Growth and Migration via Regulation of p53 Expression.
Wei Song, Hao Wang, Minmin Lu, Xinxin Ni, Nacef Bahri, Jonathan A Fletcher

Cancers (Basel)· September 2020

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Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor.
Alfonso García-Valverde, Jordi Rosell, Garazi Serna, Claudia Valverde, Joan Carles, Jonathan A Fletcher

Mol Cancer Ther· June 2020

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Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours.
Mengyuan Huang, Wenyu Yang, Jiaqing Zhu, Adrián Mariño-Enríquez, Chennianci Zhu, Jonathan A Fletcher

Br J Cancer· February 2020

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Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors.
César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M Mancuso, Jonathan A Fletcher

BMC Cancer· February 2020

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