Publications by authors named "Jonathan A Roberts"

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Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes.
Jonathan A Roberts, Andrew R Bottrill, Sharad Mistry, Richard J Evans

J Neurochem· December 2012

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Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.
Ulyana Lalo, Sarah Jones, Jonathan A Roberts, Martyn P Mahaut-Smith, Richard J Evans

J Biol Chem· September 2012

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Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.
Jonathan A Roberts, Rebecca C Allsopp, Sam El Ajouz, Catherine Vial, Ralf Schmid

Proc Natl Acad Sci U S A· March 2012

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Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation.
Ulyana Lalo, Jonathan A Roberts, Richard J Evans

J Biol Chem· September 2011

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Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.
Jonathan A Roberts, Marie Valente, Rebecca C Allsopp, David Watt, Richard J Evans

J Neurochem· May 2009

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Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.
Jonathan A Roberts, Helen R Digby, Madina Kara, Sam El Ajouz, Michael J Sutcliffe

J Biol Chem· July 2008

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Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.
Jonathan A Roberts, Richard J Evans

J Neurosci· April 2007

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Molecular properties of P2X receptors.
Jonathan A Roberts, Catherine Vial, Helen R Digby, Kelvin C Agboh, Hairuo Wen

Pflugers Arch· August 2006

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Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.
Jonathan A Roberts, Richard J Evans

J Neurochem· February 2006

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Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function.
Helen R Digby, Jonathan A Roberts, Michael J Sutcliffe, Richard J Evans

J Neurochem· December 2005

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Mutagenesis studies of conserved proline residues of human P2X receptors for ATP indicate that proline 272 contributes to channel function.
Jonathan A Roberts, Richard J Evans

J Neurochem· March 2005

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Analysis of the membrane topology of the acid-sensing ion channel 2a.
Julie A Saugstad, Jonathan A Roberts, Jin Dong, Suzanne Zeitouni, Richard J Evans

J Biol Chem· December 2004

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Molecular properties of ATP-gated P2X receptor ion channels.
Catherine Vial, Jonathan A Roberts, Richard J Evans

Trends Pharmacol Sci· September 2004

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ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.
Jonathan A Roberts, Richard J Evans

J Biol Chem· March 2004

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Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries.
Qi Xi, James Ziogas, Jonathan A Roberts, Richard J Evans, James A Angus

Br J Pharmacol· November 2002

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