Publications by authors named "Jonathan C. Morris"

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Epoxidation-Enhanced Charge-Switch Derivatization for Rapid Profiling of Monounsaturated Fatty Acid Isomers.
Sarah E Hancock, Linda Garthwaite, Laura L Y Choong, Iliya Dragutinovic, Jonathan C Morris

Anal Chem· December 2025

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The splicing factor kinase SRPK1 is a therapeutic target for peripheral vascular disease.
Sohni Ria Bhalla, Mussarat Wahid, Jason O Amartey, Amira Zawia, Federica Riu, Jonathan C Morris

Am J Physiol Heart Circ Physiol· August 2025

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Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics.
David A Neale, Jonathan C Morris, Nicole M Verrills, Alaina J Ammit

Pharmacol Ther· May 2025

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Correction: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.
Martin Wohlwend, Pirkka-Pekka Laurila, Ludger J E Goeminne, Tanes Imamura de Lima, Ioanna Daskalaki, Jonathan C Morris

Elife· May 2024

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Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion.
Mussarat Wahid, Benjamart Pratoomthai, Isioma U Egbuniwe, Hannah R Evans, Roya Babaei-Jadidi, Jonathan C Morris

Cancer Immunol Immunother· December 2023

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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Alexis Diaz-Vegas, Søren Madsen, Kristen C Cooke, Luke Carroll, Jasmine X Y Khor, Jonathan C Morris

Elife· December 2023

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Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer's disease.
Roaa H Alalwany, Tom Hawtrey, Kevin Morgan, Jonathan C Morris, Lucy F Donaldson

Front Mol Neurosci· June 2023

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Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.
Naseeb K Malhi, Claire L Allen, Elizabeth Stewart, Katherine L Horton, Federica Riu, Jonathan C Morris

Am J Physiol Heart Circ Physiol· June 2022

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Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.
Ryan J Duchatel, Abdul Mannan, Ameha S Woldu, Tom Hawtrey, Phoebe A Hindley, Jonathan C Morris

Neurooncol Adv· November 2021

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Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.
Sophie Maiocchi, Jacqueline Ku, Tom Hawtrey, Irene De Silvestro, Ernst Malle, Jonathan C Morris

Chem Res Toxicol· June 2021

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Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia.
Matthew D Dun, Abdul Mannan, Callum J Rigby, Stephen Butler, Hamish D Toop, Jonathan C Morris

Leukemia· December 2020

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Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease.
Prema M Nair, Malcolm R Starkey, Tatt Jhong Haw, Gang Liu, Adam M Collison, Jonathan C Morris

Clin Transl Immunology· October 2019

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TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.
Adam M Collison, Junyao Li, Ana Pereira de Siqueira, Xuejiao Lv, Hamish D Toop, Jonathan C Morris

BMC Pulm Med· February 2019

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M S Vijayabaskar, Jonathan C Morris

Nat Commun· December 2018

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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
Nigel Turner, Xin Ying Lim, Hamish D Toop, Brenna Osborne, Amanda E Brandon, Jonathan C Morris

Nat Commun· August 2018

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Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents.
Sophie L Maiocchi, Jonathan C Morris, Martin D Rees, Shane R Thomas

Biochem Pharmacol· July 2017

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Concise Total Synthesis of Dioncophylline E through an ortho-Arylation Strategy.
Hamish D Toop, Jason S Brusnahan, Jonathan C Morris

Angew Chem Int Ed Engl· July 2017

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Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
Jennifer Batson, Hamish D Toop, Clara Redondo, Roya Babaei-Jadidi, Apirat Chaikuad, Jonathan C Morris

ACS Chem Biol· March 2017

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Pharmacology of Modulators of Alternative Splicing.
David O Bates, Jonathan C Morris, Sebastian Oltean, Lucy F Donaldson

Pharmacol Rev· January 2017

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The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.
Md Mostafizur Rahman, Laura Prünte, Leonard F Lebender, Brijeshkumar S Patel, Ingrid Gelissen, Jonathan C Morris

Sci Rep· November 2016

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Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia.
Hamish D Toop, Matthew D Dun, Bryony K Ross, Hayley M Flanagan, Nicole M Verrills, Jonathan C Morris

Org Biomol Chem· May 2016

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Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells.
Md Mostafizur Rahman, Nowshin N Rumzhum, Philip M Hansbro, Jonathan C Morris, Andrew R Clark

Cell Signal· April 2016

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Synthesis and neuroprotective activity of dictyoquinazol A and analogues.
Yuvixza Lizarme, Jonatan Wangsahardja, Gabriella M Marcolin, Jonathan C Morris, Nicole M Jones

Bioorg Med Chem· April 2016

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Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors.
Hamish D Toop, Anthony S Don, Jonathan C Morris

Org Biomol Chem· December 2015

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Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin.
Md Mostafizur Rahman, Nowshin N Rumzhum, Jonathan C Morris, Andrew R Clark, Nicole M Verrills

Sci Rep· May 2015

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